McGill.CA / Laboratory of microbial adhesion

Papers

Selected publications

1. Peptide-based ligand antagonists block a Vibrio cholerae adhesin, BioRxiv

Wang M, Du G, Yongo-Luwawa C, Lu A, Kinrade B, Munro K, Klose KE, Lubell WD, Davies PL, Guo S (2025)

2. Structures of fibrillar adhesins that mediate bacterium-host interactions and biofilm formations, Springer Biofilm Series

Illustration of the structural models (predicted by Alphfold2) and roles of split domains in simultaneously projecting multiple domains outward from the FA linear chain (Graham et al. 2024).

Davies PL, Guo S* (2024) 

* Corresponding author

3. PilY1 regulates the dynamic architecture of the Type IV Pilus machine in Pseudomonas aeruginosa, Nature Communications

The in-situ architecture of the P. aeruginosa T4P machine reveals a cage-like structure that spans the cell envelope. In-situ architecture of the P. aeruginosa T4P machine.

Guo S*, Chang Y, Brun YV, Howell PL, Burrows LL*, Liu J* (2024)

 *Corresponding authors

4. A peptide-binding domain shared with an Antarctic bacterium facilitates Vibrio cholerae epithelial cell-binding, biofilm formation and intestinal colonization, Proceedings of the National Academy of Sciences

The FrhA PBD binds Diatoms and contributes to intestinal colonization.

Lloyd CJ, Guo S, Kinrade B, Zahiri H, Eves R, Khalid Ali S, Yildiz F, Voets IK, Davies PL, Klose KE (2023) 

5. Rotational switching, torque generation, and mechanosensing: insights into the structures and functions of the bacterial flagellar motor, Frontiers in Microbiology

Pseudoatomic structure of the stator-FliL-supramolecular complex and proposed model for modulating torque generation.

Guo S, Liu J (2022)

6. FliL-ring provides structural basis for maximal torque generation in bacterial flagellar motor, Proceedings of the National Academy of Sciences

The stator complex is surrounded by a periplasmic ring-like structure in situ.In situ architecture of the bacterial flagellar motor

Guo S#, Xu H#, Chang Y, Motaleb MdA, Liu J (2022) 

#Co-first authors.

Press: Yale School of Medicine Top Stories

7. Molecular basis for inhibition of adhesin-mediated bacterial-host interactions through a novel peptide-binding domain, Cell Reports

Structure-guided design of inhibitors to block bacterial adhesion

Guo S, Zahiri H, Stevens CA, Spaanderman DC, Milroy LG, Ottmann C, Brunsveld L, Voets IK, Davies PL (2021) 

8. Structural basis of ligand selectivity by a bacterial adhesin lectin involved in multi-species biofilm formation, mBio

Ligand-binding site of MpPA14 in complex with GlcNAc and l-fucose.

Guo S, Vance TDR, Zahiri H, Eves R, Stevens CA, Hehemann JH, Vidal-Melgosa S, Davies PL (2021)

9. A simple method to create hydrophobic mortar using bacteria grown in liquid cultures, Construction and Building Materials

The microstructure and wetting property of the reference and bacteria-modified (5%wt) mortars determined by SEM and static water contact angle measurements.

Qu Z*, Guo S*#, Zheng Y*, Giakoumatos EC, Yu Q, Voets IK# (2021)

*Equal contributions. #Corresponding authors

10. Engineered living materials based on adhesin-mediated trapping of programmable cells, ACS Synthetic Biology

PATCH engineered to kill S. aureus

Guo S*#, Dubuc E#, Rave Y, Twisk S.A.E., Van der Hek T, Verhagen M.P.A., Oerlemans G.J.M, Van den Oetelaar M.C.M, Van Hazendonk L.S, Sharma M, Brüls M, Eijkens B.V, Joostens P.L, Keij S.R, Xing W, Merkx M, Voets K*, De Greef T* (2020)

* Corresponding author. #Co-first authors

11. Phasing with Ca2+ at home, Acta Crystallographica F

Sample electron densities showing calcium-binding sites and surrounding amino acids.

Guo S, Campbell RL, Davies PL, Allingham JS (2019) 

12. RTX Adhesins are key bacterial surface megaproteins in the formation of biofilms, Trends in Microbiology

Schematic of MpIBP Binding Marinomonas primoryensis and Diatoms to Ice.

Guo S, Vance TDR, Stevens CA, Voets IK, Davies PL (2019) 

13. Enhancing The freeze-thaw durability of concrete through ice recrystallization inhibition by poly(vinyl alcohol). ACS Omega

Enhancing the Freeze–Thaw Durability of Concrete through Ice Recrystallization Inhibition by Poly(vinyl alcohol)

Qu Z, Guo S*, Sproncken CCM, Suris-Vals R, Brouwers JH, Yu Q, Voets IK* (2019) 

* Corresponding author

14. Conserved structural features anchor biofilm-associated RTX–adhesins to the outer membrane of bacteria, The FEBS Journal

Conserved structural features anchor biofilm-associated RTX–adhesins to the outer membrane of bacteria

Guo S, Langelaan DN, Phippen SW, Smith SP, Voets IK, Davies PL (2018) 

15. Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice, Science Advances

Structure of a 1.5-MDa adhesinStructure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice

Guo S, Stevens CA, Vance TDR, Olijve LLC, Graham LA, Campbell RL, Yazdi SR, Escobedo C, Bar-Dolev M, Yashunsky V, Braslavsky I, Langelaan DN, Smith SP, Allingham JS, Voets IK, Davies PL (2017) 

Press: C&EN, Scientific American, TU/e news

16. Ca2+-stabilized adhesin helps an Antarctic bacterium reach out and bind ice. Bioscience Rep

Ca2+-stabilized adhesin helps an Antarctic bacterium reach out and bind ice

Vance TDR, Olijve LLC, Campbell RL, Voets IK, Davies PL, Guo S* (2014) 

*Corresponding author

17. Role of Ca2+ in folding the tandem β-sandwich extender domains of a bacterial ice-binding adhesin, The FEBS Journal

Role of Ca2+ in folding the tandem β-sandwich extender domains of a bacterial ice-binding adhesin

Guo S, Garnham CP, Partha-Karunan S, Campbell RL, Allingham JS, Davies PL (2013) 

18. Re-Evaluation of a bacterial antifreeze protein as an adhesin with ice-binding activity, PLoS One.

Re-Evaluation of a bacterial antifreeze protein as an adhesin with ice-binding activity

Guo S, Garnham CP, Whitney JC, Graham LA, Davies PL (2012) 

Other collaborative publications

 

1. A newly characterized cyanobacterial strain, Cyanobium sp.MMK01: practical strategy towards developing a methodology to achieve C-phycocyanin with ultra-high purity, Frontiers in Microbiology

A newly characterized cyanobacterial strain, Cyanobium sp.MMK01

Shafiei M, Shafiei M, Sani NM, Zahiri HS, Guo W, Kermani AA, Guo S, Vali H, Noghabi KA (2024) 

2. Development of supramolecular polymer nanostructure for cellular uptake, Journal of Material Chemistry B

Development of supramolecular polymer nanostructure for cellular uptake

Song J, Fransen PP, Bakker M, Wijnands S, Huang J, Guo S, Dankers P (2024) 

3. Adhesin domains responsible for binding bacteria to surfaces they colonize project outwards from companion split domains, Proteins

Adhesin domains responsible for binding bacteria to surfaces they colonize project outwards from companion split domains

Graham LA, Hansen T, Yang Y, Sherik M, Ye Q, Kinrade B, Guo S, Davies (2024) 

4. Pleiotropic role of sialidase in the pathogenicity of Porphyromonas gingivalis, Infection and Immunity

Pleiotropic role of sialidase in the pathogenicity of Porphyromonas gingivalis

Pham C, Guo S, Han X, Coleman L, Wang H, Liu J, Sze CW, Li CA (2024) 

5. Outer membrane vesicles and the outer membrane protein OmpU govern Vibrio cholerae biofilm matrix assembly, mBio

Outer membrane vesicles and the outer membrane protein OmpU govern Vibrio cholerae biofilm matrix assembly

Potapova A, Garvey W, Dahl P, Guo S, Chang Y, Schwechheimer C, Trebino MA, Floyd K, Phinney B, Liu J, Malvankar NS, Yildiz FH (2024) 

6. Sugar-binding and split domain combinations in repeats-in-toxin adhesins from Vibrio cholerae and Aeromonas veronii mediate cell-surface recognition and hemolytic activities, mBio

Sugar-binding and split domain combinations in repeats-in-toxin adhesins from Vibrio cholerae and Aeromonas veronii mediate cell-surface recognition and hemolytic activities

Sherik M, Eves R, Guo S, Lloyd CJ, Klose KE, Davies PL (2024) 

7. Highly conserved, positively charged tandem repeats mediate multimerization of ice nucleation proteins, eLife

Highly conserved, positively charged tandem repeats mediate multimerization of ice nucleation proteins

Hansen T, Lee JC, Reicher N, Ovadia G, Guo S, Guo W, Liu J, Braslavsky I, Rudich Y, Davies PL (2023) 

8. Engineering Supramolecular Antimicrobial Assemblies, Journal of Polymer Science

Song J, Schmitz MGJ, Riool M, Guo S, Zaat SAJ, Dankers P (2023) 

9. FlhG in the endoflagella-containing spirochete Leptospira, Molecular Microbiology.

FlhG in the endoflagella-containing spirochete Leptospira

Fule L, Halifa R, Fontana C, Sismeiro O, Legendre R, Varet H, Coppee JY, Murray GL, Adler B, Hendrixson DR, Buschiazzo A, Guo S, Liu J, Picardeau M (2021) 

10. Putting life on ice: Bacteria that bind to frozen water. Journal of the Royal Society Interface

Bacteria that bind to frozen water

Bar-Dolev M, Bernheim R, Guo S, Davies PL, Braslavsky I (2016)

11. Blocking rapid ice crystal growth through non-basal plane adsorption of antifreeze proteins, Proceedings of the National Academy of Sciences

Blocking rapid ice crystal growth through non-basal plane adsorption of antifreeze proteins

Olijve LLC, Meister K, DeVries AL, Duman JG, Guo S, Bakker HJ, Voets IK (2016) 

12. Modelling repetitive, non-globular proteins, Proteins

Modelling repetitive, non-globular proteins

Basu K, Campbell RL, Guo S, Sun T, Davies PL (2016)

13. Structure and functional analysis of a bacterial adhesin sugar-binding domain, PLoS ONE

Structure and functional analysis of a bacterial adhesin sugar-binding domain

Vance TDR, Guo S, Assaie-Ardakany S, Conroy B, and Davies PL (2019) 

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