Eliane Kobayashi, MD, PhD
Associate Professor
Program Director, Frederick Andermann Clinical and Research Fellowship in Epileptology and EEG, Montreal Neurological Hospital
Director, Epilepsy Pediatric Transition Clinic and Program, Montreal Neurological Hospital
Eliane Kobayashi is a neurologist with expertise in the field of Epilepsy. Her main interests include:
- Genotype-phenotype correlation in familial epilepsies, to understand how the genetic basis influence the clinical presentation and structural/functional abnormalities in patients with inherited forms of epilepsy, especially temporal lobe epilepsies.
- Application of multimodal neurophysiology, structural and functional neuroimaging for the evaluation of propagation of epileptic activity and the extent of the epileptogenic network (magnetoencephalography/magnetic source imaging, combined recording of electroencephalogram and functional magnetic resonance imaging, magnetic resonance spectroscopy.
- Understanding the mechanisms underlying hyperexcitability in epilepsy and their relationship with seizure vulnerability and seizure intractability (using receptor binding studies with positron emission tomography, autoradiography, immunohistochemistry and gene expression studies).
Epilepsy
Lam J, DuBois JM, Rowley J, Rousset OG, González-Otárula KA, Soucy JP, Massarweh G, Hall JA, Guiot MC, Zimmermann M, Minuzzi L, Rosa-Neto P, Kobayashi E. In vivo hippocampal cornu ammonis 1-3 glutamatergic abnormalities are associated with temporal lobe epilepsy surgery outcomes. Epilepsia. 2021 Jul;62(7):1559-1568. doi: 10.1111/epi.16952. PMID: 34060082.
DuBois JM, Mathotaarachchi S, Rousset OG, Sziklas V, Sepulcre J, Guiot MC, Hall JA, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E. Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia. Neuroimage Clin. 2021;29:102552. doi: 10.1016/j.nicl.2020.102552. EPMID: 33401137
Lam J, DuBois JM, Rowley J, González-Otárula KA, Soucy JP, Massarweh G, Hall JA, Guiot MC, Rosa-Neto P, Kobayashi E. In vivo metabotropic glutamate receptor type 5 abnormalities localize the epileptogenic zone in mesial temporal lobe epilepsy. Ann Neurol. 2019 Feb;85(2):218-228. doi: 10.1002/ana.25404. PMID: 30597619.
DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E. Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging. Cereb Cortex. 2016 Oct 17;26(11):4170-4179. doi: 10.1093/cercor/bhw249. PMID: 27578494
DuBois JM, Rousset OG, Rowley J, Porras-Betancourt M, Reader AJ, Labbe A, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E. Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET. Eur J Nucl Med Mol Imaging. 2016 Jan;43(1):152-162. doi: 10.1007/s00259-015-3167-6. PMID: 26290423.
Benjumeda M, Tan YL, González Otárula KA, Chandramohan D, Chang EF, Hall JA, Bielza C, Larrañaga P, Kobayashi E, Knowlton RC. Patient specific prediction of temporal lobe epilepsy surgical outcomes. Epilepsia. 2021 Sep;62(9):2113-2122. doi: 10.1111/epi.17002. PMID: 34275140.
Aydin Ü, Pellegrino G, Ali OBK, Abdallah C, Dubeau F, Lina JM, Kobayashi E, Grova C. Magnetoencephalography resting state connectivity patterns as indicatives of surgical outcome in epilepsy patients. J Neural Eng. 2020 Jun 12;17(3):035007. doi: 10.1088/1741-2552/ab8113. PMID: 32191632.
Pellegrino G, Hedrich T, Sziklas V, Lina JM, Grova C, Kobayashi E. How cerebral cortex protects itself from interictal spikes: The alpha/beta inhibition mechanism. Hum Brain Mapp. 2021 Aug 1;42(11):3352-3365. doi: 10.1002/hbm.25422. PMID: 34002916
Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E. Accuracy and spatial properties of distributed magnetic source imaging techniques in the investigation of focal epilepsy patients. Hum Brain Mapp. 2020 Aug 1;41(11):3019-3033. doi: 10.1002/hbm.24994. PMID: 32386115
Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C. Source localization of the seizure onset zone from ictal EEG/MEG data. Hum Brain Mapp. 2016 Jul;37(7):2528-46. doi: 10.1002/hbm.23191. PMID: 27059157
Grova C, Aiguabella M, Zelmann R, Lina JM, Hall JA, Kobayashi E. Intracranial EEG potentials estimated from MEG sources: A new approach to correlate MEG and iEEG data in epilepsy. Hum Brain Mapp. 2016 May;37(5):1661-83. doi: 10.1002/hbm.23127. PMID: 26931511
von Ellenrieder N, Pellegrino G, Hedrich T, Gotman J, Lina JM, Grova C, Kobayashi E. Detection and Magnetic Source Imaging of Fast Oscillations (40-160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients. Brain Topogr. 2016 Mar;29(2):218-31. doi: 10.1007/s10548-016-0471-9. PMID: 26830767
Heers M, Hedrich T, An D, Dubeau F, Gotman J, Grova C, Kobayashi E. Spatial correlation of hemodynamic changes related to interictal epileptic discharges with electric and magnetic source imaging. Hum Brain Mapp. 2014 Sep;35(9):4396-414. doi: 10.1002/hbm.22482. PMID: 24615912