We believe that the role of science in improving the quality of life of all societies must be facilitated through collaboration between researchers and shared knowledge. The primary goal of our Centre is to help the scientific community achieve the research goals, but also disseminate knowledge in the form of public outreach. The diverse and complementary expertise of our members promotes microbiome research across many scientific domains. Check out some examples by exploring the left menu.
2024
Primary research contributions
1. Pidgeon Mitchell S, Shamash M, Suleiman L, Dridi L, Maurice CF, Castagner B. The dietary ellagitannin metabolite urolithin A is produced by a molybdenum-dependent dehydroxylase encoded by prevalent human gut Enterocloster spp. In review at Nature Communications, and on Biorxiv: https://www.biorxiv.org/content/10.1101/2024.02.08.579493v2
2. Vigano M, Kubal S, Lu Y, Habib S, Samarani S, Cama G, Viau C, Farzin H, Koudieh N, Xia J, Ahmad A, Vigano A, Costiniuk CT. Impact of Cannabidiol and Exercise on Clinical Outcomes and Gut Microbiota for Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors: A Case Report .Pharmaceuticals (Basel). 2024 Jun 25;17(7):834. doi: 10.3390/ph17070834.PMID: 39065685.
3. Logel M, El-Zein M, Franco EL, Gonzalez E.J. Species-level characterization of the cervicovaginal microbiota and its role in human papillomavirus-associated cervical carcinogenesis. Med Virol. 2024 Jun;96(6):e29764. doi: 10.1002/jmv.29764.PMID: 38923577.
4. Bogza A, King IL, Maurice CF. Worming into infancy: Exploring helminth-microbiome interactions in early life. Cell Host Microbe. 2024 May 8;32(5):639-650. doi:10.1016/j.chom.2024.04.009.PMID: 38723604.
5. Ding W, Chen L, Xia J, Dong G, Song B, Pei B, Li X. Causal relationships between gut microbiome and digestive system diseases: A two-sample Mendelian randomization study. Medicine (Baltimore). 2024 Apr 26;103(17):e37735. doi: 10.1097/MD.0000000000037735.PMID: 38669367.
6. Ajeeb TT, Gonzalez E, Solomons NW, Vossenaar M, Koski KG. Human milk microbiome: associations with maternal diet and infant growth. Front Nutr. 2024 Mar 11;11:1341777. doi: 10.3389/fnut.2024.1341777. eCollection 2024.PMID: 38529196.
Conferences and medias appearances
2. Futurity, September 5th, 2023, Dr. Jesse Shapiro, https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.futurity.org%2Fcovid-infections-animals-2969542%2F&data=05%7C02%7Ccynthia.faubert%40mcgill.ca%7C38a0c2f80d9441d5b3c008dc80dfa08d%7Ccd31967152e74a68afa9fcf8f89f09ea%7C0%7C0%7C638526945152679820%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=Y8QZFTaAb9cNw9FKvjgd9FjaTiGlTEl3ee78qs224Hs%3D&reserved=0
3. Podcast interview - This Week in Virology, November 1st, 2023, Dr. Corinne Maurice and Dr. Jesse Shapiro, https://www.microbe.tv/twiv/twiv-1077/
4. Youtube interview, Discussing species concepts, November 30th, 2023, Dr. Jesse Shapiro, https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Ft.co%2FMvuxTAefks&data=05%7C02%7Ccynthia.faubert%40mcgill.ca%7C38a0c2f80d9441d5b3c008dc80dfa08d%7Ccd31967152e74a68afa9fcf8f89f09ea%7C0%7C0%7C638526945152689884%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=sjk04T8drbfx%2Fj20aBgb4i95p7hh7EA7gBielRVA0Uo%3D&reserved=0
5. Moteur de recherche, March 2024, Using worms to protect against intestinal diseases, Dr. Corinne Maurice, https://ici.radio-canada.ca/ohdio/premiere/emissions/moteur-de-recherche/episodes/786853/rattrapage-jeudi-7-mars-2024/3
6. The Centre has co-hosted a one-day seminar with the AMR Centre on February 8th, 2024. Keynote speaker: Dr. Gautam Dantas from Washington University in St. Louis, Title: Understanding, Predicting, and Remediating Perturbations to Diverse Microbiomes.
2023
Primary research contributions
1. Lu Y, Zhou G, Ewald J, Pang Z, Shiri T, Xia J. MicrobiomeAnalyst 2.0: comprehensive statistical, functional and integrative analysis of microbiome data. Nucleic Acids Res. 2023 May 11:gkad407. doi: 10.1093/nar/gkad407. Online ahead of print.PMID: 37166960.
2. Stockdale SR, Hill C. Incorporating plasmid biology and metagenomics into a holistic model of the human gut microbiome. Curr Opin Microbiol. 2023 Mar 30;73:102307. doi: 10.1016/j.mib.2023.102307. Online ahead of print.PMID: 37002975 Free article. Review.
3. Madi N, Chen D, Wolff R, Shapiro BJ, Garud NR. Community diversity is associated with intra-species genetic diversity and gene loss in the human gut microbiome. Elife. 2023 Feb 9;12:e78530. doi: 10.7554/eLife.78530.PMID: 36757364 Free PMC article.
4. Dridi L, Altamura F, Gonzalez E, Lui O, Kubinski R, Pidgeon R, Montagut A, Chong J, Xia J, Maurice CF, Castagner B. Identifying glycan consumers in human gut microbiota samples using metabolic labeling coupled with fluorescence-activated cell sorting. Nat Commun. 2023 Feb 7;14(1):662. doi: 10.1038/s41467-023-36365-8.PMID: 36750571 Free PMC article.
5. Lui O, Dridi L, Gonzalez E, Yasmine S, Kubinski R, Billings H, Bohlmann J, Withers SG, Maurice C, Castagner B. Characterizing the Effect of Amylase Inhibitors on Maltodextrin Metabolism by Gut Bacteria Using Fluorescent Glycan Labeling. ACS Chem Biol. 2023 Feb 17;18(2):356-366. doi: 10.1021/acschembio.2c00791. Epub 2023 Feb 2.PMID: 36728836 Free article.
6. Minerbi A, Gonzalez E, Brereton N, Fitzcharles MA, Chevalier S, Shir Y. Altered serum bile acid profile in fibromyalgia is associated with specific gut microbiome changes and symptom severity. Pain. 2023 Feb 1;164(2):e66-e76. doi: 10.1097/j.pain.0000000000002694. Epub 2022 May 19.PMID: 35587528.
7. Majumder S, Sackey T, Viau C, Park S, Xia J, Ronholm J, George S. Genomic and phenotypic profiling of Staphylococcus aureus isolates from bovine mastitis for antibiotic resistance and intestinal infectivity. BMC Microbiol. 2023 Feb 20;23(1):43. Doi: 10.1186/s12866-023-02785-1.
8. Sutcliffe SG, Reyes A, Maurice CF. Bacteriophages playing nice: Lysogenic bacteriophage replication stable in the human gut microbiota. iScience. 2023 Jan 18;26(2):106007. doi: 10.1016/j.isci.2023.106007. eCollection 2023 Feb 17.PMID: 36798434 Free PMC article.
Conferences and medias appearances
1. McGill University Health Centre Foundation Event, Supporting microbiome research at McGill University, Dr. I. King, 2023.
2. iHeartRadio.ca, CJAD800 – Health Matters with Tara Schwartz, The gut microbiome: a new treatment for chronic pain syndrome, Dr. I. King, 2023.
2022
Primary research contributions
1. Hajjar R, Gonzalez E, Fragoso G, Oliero M, Alaoui AA, Calvé A, Vennin Rendos H, Djediai S, Cuisiniere T, Laplante P, Gerkins C, Ajayi AS, Diop K, Taleb N, Thérien S, Schampaert F, Alratrout H, Dagbert F, Loungnarath R, Sebajang H, Schwenter F, Wassef R, Ratelle R, Debroux E, Cailhier JF, Routy B, Annabi B, Brereton NJB, Richard C, Santos MM. Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines. Gut. 2023 Jun;72(6):1143-1154. doi: 10.1136/gutjnl-2022-328389. Epub 2022 Dec 30.PMID: 36585238.
2. Ajeeb TT, Gonzalez E, Solomons NW, Koski KG. Human milk microbial species are associated with infant head-circumference during early and late lactation in Guatemalan mother-infant dyads. Front Microbiol. 2022 Nov 16;13:908845. doi: 10.3389/fmicb.2022.908845. eCollection 2022.PMID: 36466698 Free PMC article.
3. Lopez Leyva L, Gonzalez E, Solomons NW, Koski KG. Human milk microbiome is shaped by breastfeeding practices.Front Microbiol. 2022 Sep 8;13:885588. doi: 10.3389/fmicb.2022.885588. eCollection 2022.PMID: 36160202 Free PMC article.
4. Sinha A, Li Y, Mirzaei MK, Shamash M, Samadfam R, King IL, Maurice CF. Transplantation of bacteriophages from ulcerative colitis patients shifts the gut bacteriome and exacerbates the severity of DSS colitis. Microbiome. 2022 Jul 8;10(1):105. doi: 10.1186/s40168-022-01275-2.PMID: 35799219 Free PMC article.
5. Shkoporov AN, Turkington CJ, Hill C. Mutualistic interplay between bacteriophages and bacteria in the human gut. Nat Rev Microbiol. 2022 Dec;20(12):737-749. doi: 10.1038/s41579-022-00755-4. Epub 2022 Jun 30.PMID: 35773472 Review.
6. Klassen L, Reintjes G, Li M, Jin L, Amundsen C, Xing X, Dridi L, Castagner B, Alexander TW, Abbott DW. Fluorescence activated cell sorting and fermentation analysis to study rumen microbiome responses to administered live microbials and yeast cell wall derived prebiotics. Front Microbiol. 2023 Mar 3;13:1020250. doi: 10.3389/fmicb.2022.1020250. eCollection 2022.PMID: 36938132 Free PMC article. Review.
7. Shamash M, Maurice CF. Phages in the infant gut: a framework for virome development during early life. ISME J. 2022 Feb;16(2):323-330. doi: 10.1038/s41396-021-01090-x. Epub 2021 Aug 20.PMID: 34417565 Free PMC article. Review. No abstract available.
8. Galipeau HJ, Verdu EF. The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential. Mucosal Immunol. 2022 Feb;15(2):235-243. doi: 10.1038/s41385-021-00479-3. Epub 2022 Jan 14.PMID: 35031683 Free article. Review.
9. Shimbori C, De Palma G, Baerg L, Lu J, Verdu EF, Reed DE, Vanner S, Collins SM, Bercik P. Gut bacteria interact directly with colonic mast cells in a humanized mouse model of IBS. Gut Microbes. 2022 Jan-Dec;14(1):2105095. doi: 10.1080/19490976.2022.2105095.PMID: 35905313 Free PMC article.
10. Jin Z, Ng A, Maurice CF, Juncker D. The Mini Colon Model: a benchtop multi-bioreactor system to investigate the gut microbiome. Gut Microbes. 2022 Jan-Dec;14(1):2096993. doi: 10.1080/19490976.2022.2096993.PMID: 35844189 Free PMC article.
Conferences and medias appearances
1. Radboud University Seminar Series, Is natural IL-17 production during early life a harbinger of intestinal resilience? Invited speaker, Dr. I King, Nov 2022.
2. University of Liege Seminar Series, Is natural IL-17 production during early life a harbinger of intestinal resilience? Invited speaker, Dr. I King, Nov 2022.
3. 7th Annual International Conference on Modulating the Environment with Microbes, Indian Network for Soil Contamination Research (INSCR). Using bacteriophages to modulate the gut microbiome, invited speaker (virtual), Dr. C. Maurice, November 2022.
4. Institut Pasteur, France. Looking for Darwin's footprints in bacterial pangenomes, invited speaker, Dr. B. Jesse Shapiro, October 6, 2022.
5. Summer School 2022: Phage Canada 2022 Virtual Symposia. SEA-PHAGES at McGill University, invited speaker, Dr. C. Maurice, August 2022.
6. ISME 18, 18th International Symposium on Microbial Ecology, Lausanne, Switzerland. From early life to adulthood, contrasting interactions of phages and bacteria in the human gut. Co-session chair of Microbial ecology of viruses and phages, invited speaker, Dr. C. Maurice, August 2022
7. 89eme Congres de l’Acfas, Université Laval, Quebec, Canada. Bacteriophages intestinaux et sante humaine: un couteau a double tranchant. Invited speaker, Dr. C. Maurice, May 2022.
8. National Public Radio and Undark by Emily Laber-Warren, Scientists explore why some people are able to live with an infection unscathed, Dr. I. King, 2022.
9. Health Matters Podcast with Tara Schwartz in cooperation with the McGill University Health Centre (March 30, 2022), Dr. Irah King interview: Gut Health and the McGill Centre for Microbiome Research.
2021
Primary research contributions
1. Lu Y, Chong J, Shen S, Chammas JB, Chalifour L, Xia J. TrpNet: Understanding Tryptophan Metabolism across Gut Microbiome. Metabolites. 2021 Dec 23;12(1):10. doi: 10.3390/metabo12010010.PMID: 35050132 Free PMC article.
2. Bilal M, Achard C, Barbe F, Chevaux E, Ronholm J, Zhao X. Bacillus pumilus and Bacillus subtilis Promote Early Maturation of Cecal Microbiota in Broiler Chickens. Microorganisms. 2021 Sep 7;9(9):1899. doi: 10.3390/microorganisms9091899.PMID: 34576794 Free PMC article.
3. Graef FA, Celiberto LS, Allaire JM, Kuan MTY, Bosman ES, Crowley SM, Yang H, Chan JH, Stahl M, Yu H, Quin C, Gibson DL, Verdu EF, Jacobson K, Vallance BA. Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection. PLoS Pathog. 2021 Aug 5;17(8):e1009719. doi: 10.1371/journal.ppat.1009719. eCollection 2021 Aug.PMID: 34352037 Free PMC article.
4. N'Guessan A, Brito IL, Serohijos AWR, Shapiro BJ. Mobile Gene Sequence Evolution within Individual Human Gut Microbiomes Is Better Explained by Gene-Specific Than Host-Specific Selective Pressures. Genome Biol Evol. 2021 Aug 3;13(8):evab142. doi: 10.1093/gbe/evab142.PMID: 34132784 Free PMC article.
5. Levin D, De Palma G, Zou H, Bazzaz AHZ, Verdu E, Baker B, Pinto-Sanchez MI, Khalidi N, Larché MJ, Beattie KA, Bercik P. Fecal microbiome differs between patients with systemic sclerosis with and without small intestinal bacterial overgrowth. J Scleroderma Relat Disord. 2021 Oct;6(3):290-298. doi: 10.1177/23971983211032808. Epub 2021 Jul 24.PMID: 35382497 Free PMC article.
6. Karo-Atar D, Khan N, Divangahi M, King IL. Helminth-mediated disease tolerance in TB: A role for microbiota? PLoS Pathog. 2021 Jul 15;17(7):e1009690. doi: 10.1371/journal.ppat.1009690. eCollection 2021 Jul.PMID: 34265025 Free PMC article. Review. No abstract available.
7. Hill C. Microbiome and Infection: A Case for "Selective Depletion". Ann Nutr Metab. 2021 May 26:1-6. doi: 10.1159/000516399. Online ahead of print.PMID: 34038906 Free article.
8. Haçariz O, Viau C, Karimian F, Xia J. The symbiotic relationship between Caenorhabditis elegans and members of its microbiome contributes to worm fitness and lifespan extension. BMC Genomics. 2021 May 19;22(1):364. doi: 10.1186/s12864-021-07695-y.PMID: 34011272 Free PMC article.
9. Lopez Leyva L, Gonzalez E, Li C, Ajeeb T, Solomons NW, Agellon LB, Scott ME, Koski KG. Human Milk Microbiota in an Indigenous Population Is Associated with Maternal Factors, Stage of Lactation, and Breastfeeding Practices. Curr Dev Nutr. 2021 Apr 15;5(4):nzab013. doi: 10.1093/cdn/nzab013. eCollection 2021 Apr.PMID: 33898919 Free PMC article.
10. Sutcliffe SG, Shamash M, Hynes AP, Maurice CF. Common Oral Medications Lead to Prophage Induction in Bacterial Isolates from the Human Gut. Viruses. 2021 Mar 11;13(3):455. doi: 10.3390/v13030455.PMID: 33799646 Free PMC article.
11. McHugh AJ, Yap M, Crispie F, Feehily C, Hill C, Cotter PD. Microbiome-based environmental monitoring of a dairy processing facility highlights the challenges associated with low microbial-load samples. NPJ Sci Food. 2021 Feb 15;5(1):4. doi: 10.1038/s41538-021-00087-2.PMID: 33589631 Free PMC article.
12. Gonzalez E, Brereton NJB, Li C, Lopez Leyva L, Solomons NW, Agellon LB, Scott ME, Koski KG. Distinct Changes Occur in the Human Breast Milk Microbiome Between Early and Established Lactation in Breastfeeding Guatemalan Mothers. Front Microbiol. 2021 Feb 12;12:557180. doi: 10.3389/fmicb.2021.557180. eCollection 2021.PMID: 33643228 Free PMC article.
13. Dohlman AB, Arguijo Mendoza D, Ding S, Gao M, Dressman H, Iliev ID, Lipkin SM, Shen X. The cancer microbiome atlas: a pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants. Cell Host Microbe. 2021 Feb 10;29(2):281-298.e5. doi: 10.1016/j.chom.2020.12.001. Epub 2021 Jan 6.PMID: 33382980 Free PMC article.
14. Taguer M, Shapiro BJ, Maurice CF. Translational activity is uncoupled from nucleic acid content in bacterial cells of the human gut microbiota. Gut Microbes. 2021 Jan-Dec;13(1):1-15. doi: 10.1080/19490976.2021.1903289.PMID: 33779505 Free PMC article.
2020
Primary research contributions
1. Fiers WD, Leonardi I, Iliev ID. From Birth and Throughout Life: Fungal Microbiota in Nutrition and Metabolic Health. Annu Rev Nutr. 2020 Sep 23;40:323-343. doi: 10.1146/annurev-nutr-013120-043659. Epub 2020 Jul 17.PMID: 32680437 Free PMC article.
2. Guerin E, Hill C. Shining Light on Human Gut Bacteriophages. Front Cell Infect Microbiol. 2020 Sep 10;10:481. doi: 10.3389/fcimb.2020.00481. eCollection 2020.PMID: 33014897 Free PMC article. Review.
3. Altamura F, Maurice CF, Castagner B. Drugging the gut microbiota: toward rational modulation of bacterial composition in the gut. Curr Opin Chem Biol. 2020 Jun;56:10-15. doi: 10.1016/j.cbpa.2019.09.005. Epub 2019 Nov 1.PMID: 31678829 Review.
4. Liu X, Teixeira JS, Ner S, Ma KV, Petronella N, Banerjee S, Ronholm J. Exploring the Potential of the Microbiome as a Marker of the Geographic Origin of Fresh Seafood. Front Microbiol. 2020 Apr 17;11:696. doi: 10.3389/fmicb.2020.00696. eCollection 2020.PMID: 32362885 Free PMC article.
5. Renteria AE, Maniakas A, Mfuna LE, Asmar MH, Gonzalez E, Desrosiers M. Low-dose and long-term azithromycin significantly decreases Staphylococcus aureus in the microbiome of refractory CRS patients. Int Forum Allergy Rhinol. 2021 Feb;11(2):93-105. doi: 10.1002/alr.22653. Epub 2020 Jul 26.PMID: 32713109 Clinical Trial.
6. Verdu EF, Schuppan D. The enemy within the gut: bacterial pathogens in celiac autoimmunity. Nat Struct Mol Biol. 2020 Jan;27(1):5-7. doi: 10.1038/s41594-019-0360-5.PMID: 31873302 No abstract available.
Conferences and medias appearances
1. The Influence of Gut Virome and the Immune System on Intestinal Health – Webinar sponsored by Charles River Laboratory. King IL, Maurice CF, December 10, 2020. https://www.criver.com/resources/webinar-pi-ds-influence-gut-virome-and-immune-system-intestinal-health
2. Scientists Explore Why Some People Are Able To Live With An Infection Unscathed – by Undark, a nonprofit, editorially independent digital magazine. King IL, August 29, 2020. https://www.npr.org/sections/health-shots/2020/08/29/906268526/scientists-explore-why-some-people-are-able-to-live-with-an-infection-unscathed
3. Four reasons to come to terms with viruses – by Radio-Canada. Maurice CF, Shapiro J, May 16th, 2020. https://www.youtube.com/watch?v=3WKn9ZsUnys
4. Tracking down the pandemic in the sewers: Update with Alexandre Touchette – by Radio-Canada. King IL, April 12, 2020. https://ici.radio-canada.ca/ohdio/premiere/emissions/les-annees-lumiere/segments/reportage/165150/covid-sras-egouts-epuration-gastro-intestinal