Education and training:
PDf. (Genetics) McGill University, Canada, since 2012
PhD. (Bio-chemistry) Homi Bhabha National Institute, Mumbai, India, 2010
MSc. (Biotechnology) Tamil Nadu Agricultural University, India, 2002
BSc. (Agriculture) Banaras Hindu University, India, 2000
Publications:
K. I. Priyadarsini, B. G. Singh and A. Kunwar. Current developments on synthesis, redox reactions and biochemical studies of selenium antioxidants. Current Chemical Biology, 2012 (accepted for publication)
A. Kunwar, B. Adhikary, S. Jayakumar, A. Barik, S. Chattopadhyay, S. Raghukumar, K. I. Priyadarsini. Melanin, a promising radioprotector: Mechanisms of actions in a mice model
Toxicol. Appl. Pharmacol. 2012 Toxicol. Appl. Pharmacol. 2012, 264:202-211.
P. Bansal, P. Paul, A. Kunwar, S. Jayakumar, P.G. Nayak, K.I. Priyadarsini, M.K. Unnikrishnan. Radioprotection by quercetin-3-O-rutinoside, a flavonoid glycoside – A cellular and mechanistic approach. J. Functional Food 2012, 4:924-932.
Kumar S, Kunwar A, Gautam S, Sharma A. Inactivation of A. ochraceus spores and detoxification of ochratoxin A in coffee beans by gamma irradiation. J Food Sci. 2012 Feb;77(2):T44-51.
Kunwar A, Jayakumar S, Srivastava AK, Priyadarsini KI. Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: Evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis. Arch Toxicol. 2012 Apr;86(4):603-14.
Kunwar A, Priyadarsini KI. Free radicals, oxidative stress and importance of antioxidants in human health (review article). Journal of Medical and Allied Sciences 2011, 1(2):53-60.
Kunwar A, Bag PP, Chattopadhyay S, Jain VK, Priyadarsini KI. Anti-apoptotic, anti-inflammatory and immunomodulatory activities of 3,3'-diselenodipropionic acid in mice exposed to whole body γ-radiation. Arch Toxicol. 2011 Nov;85(11):1395-405.
Kunwar A, Barik A, Sandur SK, Priyadarsini KI. Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin (review article). Free Radic Res. 2011 Aug;45(8):959-65.
Kunwar A, Simon E, Singh U, Chittela RK, Sharma D, Sandur SK, Priyadarsini KI. Interaction of a curcumin analogue dimethoxycurcumin with DNA. Chem Biol Drug Des. 2011 Apr;77(4):281-7.
Kunwar, Jayakumar S, Bhilwade HN, Bag PP, Bhatt H, Chaubey RC, Priyadarsini KI. Protective effects of Selenocystine against -radiation induced genotoxicity in Swiss albino mice. Radiat Environ Biophys. 2011 May;50(2):271-80.
Kumar BS, Kunwar A, Singh BG, Ahmad A, Priyadarsini KI. Anti-hemolytic and peroxyl radical scavenging ability of organoselenium compounds. Biol Trace Elem Res. 2011 May;140(2):127-38.
Kaviarasan S, Sivakumar AS, Barik A, Kunwar A, Naik GH, Priyadarsini KI. Potent free radical scavenging ability of sunphenon: A green tea polyphenol. J Food Biochem. 2011; 35: 596-612. .
Kunwar A, Bansal P, Kumar SJ, Bag PP, Paul P, Reddy ND, Kumbhare LB, Jain VK, Chaubey RC, Unnikrishnan MK, Priyadarsini KI. In vivo radioprotection studies of 3,3'-Diselenodipropionic acid (DSePA), a selenocystine derivative. Free Radic Biol Med. 2010 Feb 1;48(3):399-410.
Kumar BS, Tiwari SK, Manoj G, Kunwar A, Amrita N, Sivaram G, Abid Z, Ahmad A, Khan AA, Priyadarsini KI. Anti-unlcer and antimicrobial activities of sodium selenite against Helicobacter pylori: In vitro and in vivo evaluation. Scand J Infect Dis. 2010 Apr;42(4):266-74.
Kumar BS, Tiwari SK, Saikant R, Manoj G, Kunwar A, Sivaram G, Abid Z, Ahmad A, Priyadarsini KI, Khan AA. Antibacterial and ulcer healing effects of organo-selenium compounds in naproxen induced and Helicobacter pylori infected Wistar rat model. J Trace Elem Med Biol. 2010 Oct;24(4):263-70.
Kunwar A, Sandur SK, Krishna M, Priyadarsini KI. Curcumin mediates time and concentration dependent regulation of redox homeostasis leading to cytotoxicity in macrophage cells. Eur J Pharmacol. 2009 Jun 2;611(1-3):8-16.
Singh U, Kunwar A, Srinivasan R, Nanjan MJ, Priyadarsini KI. Differential free radical scavenging activity and radioprotection of Caesalpinia Digyna extracts and its active constituent. J Radiat Res. 2009 Sep;50(5):425-33.
Kumar BS, Kunwar A, Ahmad A, Kumbhare LB, Jain VK, Priyadarsini KI. In vitro radioprotection studies of organoselenium compounds: differences between mono- and diselenides. Radiat Environ Biophys. 2009 Nov;48(4):379-84.
Kunwar A, Barik A, Mishra B, Rathinasamy K, Pandey R, Priyadarsini KI. Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells. Biochim Biophys Acta. 2008 Apr;1780(4):673-9.
Mishra B, Barik A, Kunwar A, Kumbhare LB, Priyadarsini KI, Jain VK. Correlating the GPx activity of selenocystine derivatives with one-electron redox reactions. Phosphorus, Sulfur, and Silicon Related Elements 2008;183:1018–1025.
Banerjee A, Kunwar A, Mishra B, Priyadarsini KI. Concentration dependent antioxidant/pro-oxidant activity of curcumin studies from AAPH induced hemolysis of RBCs. Chem Biol Interact. 2008 Jul 30;174(2):134-9.
Kunwar A, Narang H, Priyadarsini KI, Krishna M, Pandey R, Sainis KB. Delayed activation of PKCdelta and NFkappaB and higher radioprotection in splenic lymphocytes by copper (II)-Curcumin (1:1) complex as compared to curcumin. J Cell Biochem. 2007 Dec 1;102(5):1214-24. (Designed, performed the experiments, analyzed the data & wrote the paper, Contribution – 70%)
Barik A, Mishra B, Kunwar A, Priyadarsini KI. Interaction of curcumin with human serum albumin: Thermodynamic properties, Fluorescence energy transfer and Denaturation effects. Chem Phys Lett 2007;436: 239-243.
Kunwar A, Mishra B, Barik A, Kumbhare LB, Pandey R, Jain VK, Priyadarsini KI. 3, 3'-Diselenodipropionic acid, an efficient peroxyl radical scavenger and a GPx mimic, protects erythrocytes from AAPH induced haemolysis. Chem Res Toxicol. 2007 Oct;20(10):1482-7. (Designed, performed the experiments, analyzed the data & wrote the paper, Contribution – 60%)
Koiram PR, Veerapur VP, Kunwar A, Mishra B, Barik A, Priyadarsini IK, Mazhuvancherry UK. Effect of curcumin and curcumin copper complex (1: 1) on radiation induced changes of anti-oxidant enzymes levels in the livers of Swiss albino mice. J Radiat Res. 2007 May;48(3):241-5.
Barik A, Mishra B, Kunwar A, Kadam RM, Shen L, Dutta S, Padhye S, Satpati AK, Zhang Hong-Yu, Priyadarsini KI. Comparative study of copper(II)-curcumin complexes as superoxide dismutase mimics and free radical scavengers. Eur J Med Chem. 2007 Apr;42(4):431-9.
Kunwar A, Barik A, Pandey R, Priyadarsini KI. Transport of liposomal and albumin loaded curcumin to living cells: an absorption and fluorescence spectroscopic study. Biochim Biophys Acta. 2006 Oct;1760(10):1513-20
Priyadarsini KI, Mishra B, Kunwar A, Kumar S, Kumbhar LB, Jain VK. Relative free radical scavenging ability, GPx activity and in vitro radioprotection by two selenocysteine derivatives. Free Radic Biol Med. 2006;41: S14.
Kurrey NK, K A, Bapat SA. Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level. Gynecol Oncol. 2005 Apr;97(1):155-65.