Publications

"Phenol-Directed C–H Functionalization." Huang, Z.; Lumb, J. P. ACS Catal. 20199, 521-555.

"Cu(III)-Mediated Aerobic Oxidations." Esguerra, K. V. N.; Lumb, J. P. Synthesis 2018Just Accepted, DOI: 10.1055/s-0037-1609635.

"Recent Applications of Diazirines in Chemical Proteomics." Halloran, M. W.; Lumb, J. P. Chem. Eur. J. 201925, 4885-4898.

"A Bioinspired Synthesis of Polyfunctional Indoles." Huang, Z.; Kwon, O.; Huang, H.; Fadli, A.; Marat, X.; Moreau, M.; Lumb, J. P. Angew. Chem. Int. Ed. 2018, 57, 11963-11967.

"Selectivity in the Aerobic Dearomatization of Phenols: Total Synthesis of Dehydronornuciferine by Chemo- and Regioselective Oxidation." Esguerra, K. V. N.; Lumb, J. P. Angew. Chem. Int. Ed. 201857, 1514-1518.

"Catalytic Aerobic Oxidation of Halogenated Phenols." Esguerra, K. V. N.; Fall, Y.; Lumb, J. P. Inorg. Chim. Acta2017, In Press, DOI: 10.1016/j.ica.2017.08.009.

 "Stopping Aerobic Oxidation in Its Tracks: Chemoselective Synthesis of Benzaldehydes from Methylarenes." Lumb, J.-P. Angew. Chem. Int. Ed2017, 56, 9276-9277.

 “A Bioinspired Catalytic Aerobic Functionalization of Phenols: Regioselective Construction of Aromatic C–N and C–O Bonds.” Esguerra, K. V. N.; Lumb, J.-P. ACS Catalysis 20177, 3477-3482.

 "Synthesis of ortho-Azophenols by Formal Dehydrogenative Coupling of Phenols and Hydrazines or Hydrazides." Esguerra, K. V. N.; Lumb, J.-P. Chem. Eur. J. 2017, 23, 8596-8600.

  

This work was selected for the Inside Front Cover

"A Chlorine-Free Protocol for Processing Germanium." Glavinović, M.; Krause, M.; Baines, K.*; Friščić, T.*; Lumb, J.-P.* Sci. Adv. 2017, 3, e1700149 (DOI: 10.1126/sciadv.1700149).

This work has been recently highlighted by the McGill Newsroom 

 “Development of 3,5-di-tert-Butylphenol as a Model Substrate for Biomimetic Aerobic Copper Catalysis.” Kwon, O,; Esguerra, K. V. N.; Glazerman, M.; Petitjean, L.; Xu, Y.; Ottenwaelder, X.; Lumb, J.-P. Synlett 2017, 28, 1548-1553.

Invited Contribution to the Synlett Cluster on Aerobic Catalysis.

 “A Unified Synthesis of 1,2-Oxy Amino Arenes via a Bio-Inspired Phenol / Amine Coupling.” Esguerra, K.V.N.; Xu, W.; Lumb, J.-P. Chem 2017, 2, 533–549. 

preview of this work by Sanzhong Lou

A perspective on this work written by the first author Kenneth Esguerra

 “Second-Order Biomimicry: In Situ Oxidative Self-Processing Converts Copper(I)/Diamine Precursor into a Highly Active Aerobic Oxidation Catalyst.” McCann, S.; Lumb, J.-P.*; Arndtsen*, B.; Stahl, S.* ACS Cent. Sci. 2017, 3, 314-321.

This work was recently highlighted by Konev and Jarvo

 "Simple Copper Catalysts for the Aerobic Oxidation of Amines: Selectivity Control by the Counterion". Xu, B.; Hartigan, E. M.; Feula, G.; Huang, Z.; Lumb, J.-P.; Arndtsen, B. A. Angew. Chem. Int. Ed. 2016, 55, 15802-15806.

 "A Catalyst-Controlled Aerobic Coupling of ortho-Quinones and Phenols Applied to the Synthesis of Aryl Ethers". Huang, Z.; Lumb, J.-P. Angew. Chem. Int. Ed. 201655, 11543-11547.

 "Redox-promoted associative assembly of metal-organic materials". Glavinovic, M.; Qi, F.; Katsenis, A. D.; Friscic, T.; Lumb, J.-P. Chem. Sci. 2016, 7, 707-712.

 "A Bio-Inspired Synthesis of Oxindoles by Catalytic Aerobic Dual C-H Functionalization of Phenols". Huang, Z.; Askari, M. S.; Esguerra, K. V. N.; Dai, T.-Y.; Kwon, O.; Ottenwaelder, X.; Lumb, J.-P. Chem. Sci2016, 7, 358-369.

 "Adapting Melanogenesis to a Regioselective C–H Functionalization of Phenols." Esguerra, K. V. N.; Lumb, J.-P. Synlett. 2015, 26, 2731-2738.

 "A Biomimetic Mechanism for the Copper Catalyzed Aerobic Oxygenation of 4-tert-Butylphenol." Askari, M. S.; Esguerra, K. V. N.; Lumb, J.-P.; Ottenwaelder, X. Inorg. Chem. 2015, 54, 8665-8672.

 "A divergent and selective synthesis of ortho- and para-quinones from phenols." Huang, Z; Kwon, O; Esguerra, K. V. N.; Lumb, J.-P. Tetrahedron2015, 71, 5871-5885.

 "Catalytic aerobic oxidation of phenols to ortho-quinones with air-stable copper precatalysts". Askari, M.S.; Rodriguez-Salano, L. A.; Proppe, A.; McAllister, B.; Lumb, J.-P; Ottenwaelder, X.  Dalton Trans. 2015, 44, 12094-12097.

 "A TEMPO-free Copper Catalyzed Aerobic Oxidation of Alcohols." Xu, B.; Lumb, J.-P; Arndtsen, B. A. Angew. Chem. Int. Ed. 2015, 54, 4208.

"A Bio-Inspired Total Synthesis of Tetrahydrofuran Lignans." Albertson, A.K.F.; Lumb, J.-P. Angew. Chem. Int. Ed. 2015, 54, 2204.

                                                                               

This article was featured as "Synfact of the Month" in the April 2015 issue of Synfacts

"Controlling the Catalytic Aerobic Oxidation of Phenols." Esguerra, K. V. N.; Fall, Y.; Petitjean, L. Lumb, J.-P. J. Am. Chem. Soc. 2014, 136, 7662.

 "A Biomimetic Catalytic Aerobic Functionalization of Phenols." Esguerra, K. V. N.; Fall, Y.; Lumb, J. P. Angew. Chem. Int. Ed. 2014, 53, 5987.

 

Before McGill:

 “Synthesis of a 1,3-Bridged Macrobicyclic Enyne via Chemoselective Cycloisomerization Using Palladium-catalyzed Alkyne-Alkyne Coupling.” Trost, B.M.*; Masters, J. T.; Le Vaillant, F.; Lumb, J.-P. J. Org. Chem. 201681, 10023–10028.

 "Asymmetric Synthesis of Chiral b-Alkynyl Carbonyl and Sulfonyl Derivatives via Sequential Palladium and Copper Catalysis.” Trost, B.M.; Taft, B.R.; Masters, J. T.; Lumb, J.-P. Chem. Sci20167, 6217-6231.

 “Asymmetric Synthesis of Chiral Cycloalkenone Derivatives via Palladium Catalysis.” Trost, B.M.; Masters, J. T.; Lumb, J.P.; Fateen, D. Chem. Sci. 2014, 5, 1354.

 “A New Strategy for the Synthesis of Chiral β-Alkynyl Esters via Sequential Palladium and Copper Catalysis.” Trost, B.M.; Taft, B.R.; Masters, J. T.; Lumb, J. P. J. Am. Chem. Soc. 2011, 133, 8502.

 “An Atom-Economic Synthesis of Nitrogen Heterocycles from Alkynes.” Trost, B. M.; Lumb, J. P.; Azzarelli, J. M. J. Am. Chem. Soc. 2011, 133, 740.

 “Total synthesis of Exiguamines A and B Inspired by Catecholamine Chemistry.” Sofiyev, V.; Lumb, J. P.; Volgraf, M.;  Trauner, D. Chem. Eur. J. 2012. 26, 4999.

 “Theoretical Investigation of the Rubicordifolin Cascade.” Lumb, J.P.*; Krinsky, J. L.; Trauner, D. Org. Lett. 2010, 12, 5162. (*Corresponding Author)

 “ortho-Quinone Methides from para-Quinones: Total Synthesis of Rubioncolin B.” Lumb, J. P.; Choong, K. C.; Trauner, D. J. Am. Chem. Soc. 2008, 130, 9230.

 “Biomimetic Synthesis of the IDO Inhibitors Exiguamine A and B.” Volgraf, M.; Lumb, J. P.; Brastianos, H. C.; Carr, G.; Chung, M. K. W.; Munzel, M.; Mauk, A. G.; Andersen, R. J.; Trauner, D. Nature Chemical Biology, 2008, 4, 535.

 “Pericyclic Reactions of Prenylated Naphthoquinones: Biomimetic Synthesis of Mollugin and Microphyllaquinone.”  Lumb, J. P.; Trauner, D. Org. Lett. 2005, 7, 5865.

 “Biomimetic Synthesis and Structure Elucidation of Rubicordifolin, a Cytotoxic Natural Product from Rubia cordifolia.”  Lumb, J. P.; Trauner, D. J. Am. Chem. Soc. 2005, 127, 2870.

 “Polyhydroxylated aziridinylcyclopentanes as glycomimetics: A new competitive inhibitor of alpha-mannosidase.” Schoenfeld, R.; Lumb, J. P.; Ganem, B. Tetrahedron Lett., 2001, 42, 6447.

 “Total synthesis of mololipids: A new series of anti-HIV Moloka'iamine derivatives.”  Schoenfeld, R.; Lumb, J. P.; Ganem, B. Bioorg. Med. Chem. Lett., 2000, 10, 2679.

Back to top