Publications

Paul Lasko ORCID ID https://orcid.org/0000-0002-4037-3501

145. Lasko, P. and Lüthy, K. (2021) Investigating rare and ultrarare epilepsy syndromes with Drosophilamodels. Faculty Opinions, invited review, in press.

 

144. Kashkooli, L., Rozema, D., Espejo-Ramirez, L., Lasko, P., and Fagotto, F. (2021) Ectoderm to mesoderm transition by downregulation of actomyosin contractility. PLoS Biology19 (1): e3001060. PMID 33406067.

 

143. Chaouch, A. and Lasko, P. (2020) Drosophila melanogaster: a fruitful model for oncohistones. Invited review for Fly, doi 10.1080/19336934.2020.1863124.

 

142. Ramsay, C., Lasko, P., and Abouheif, E. (2020) Evo-devo lessons from the reproductive division of labour in eusocial Hymenoptera. In: Evolutionary Developmental Biology–A Reference Guide (eds. Nuño de la Rosa, L. and Müller, G. B.), published online at https://doi.org/10.1007/978-3-319-33038-9_173-1.

 

141. Kugler, J. M. and Lasko, P. (2020) Drosophilaembryo: maternal interactions in specification of the anterior-posterior axis. Encyclopedia of Life Sciences, a1503.pub2, doi 10.1002/9780470015902.a0029150.

 

140. Hernández, G., Garcia, A., Lasko, P., and Sonenberg, N. (2020) Unorthodox mechanisms to initiate translation open novel paths for gene expression. J. Mol. Biol.432: 166702. PMID 33166539.

 

139. Lasko, P. (2020) Patterning the Drosophilaembryo: a paradigm for RNA-based developmental genetic regulation. WIReS RNA, Jun 15: e1610. PMID 32543002.

 

138. Taruscio, D., Baynam, G., Cederroth, H., Groft, S. C., Klee, E. W., Kosaki, K., Lasko, P., Melegh, B., Riess, O., Salvatore, M., and Gahl, W. A. (2020) Five years later: the Undiagnosed Diseases Network International. Mol. Genet. Metab.129: 243-254. PMID 32033911.

 

137. Dold, A., Han. H., Liu, N., Hildebrandt, A., Beli, P., Brüggemann, M., Rücklé, C., Beli, P., Zarnack, K., König, J., Roignant, J.-Y., and Lasko, P.  (2020) Makorin 1 controls embryonic patterning by alleviating Bruno-mediated repression of oskartranslation. PLoS Genet., 16: e1008581. PMID 31978041.

 

136. Kong, J., Han, H., Bergalet, J., Bouvrette, L.-P. B., Hernández, G., Moon, N.-S., Vali, H., Lécuyer, E., and Lasko. P. (2019) Drosophilaribosomal protein S5b is essential for oogenesis and interacts with distinct RNAs. Sci. Rep.9: 13779. PMID 31551467.

 

135. Krug, B., De Jay, N., Harutyunyan, A. S., Deshmukh, S., Marchione, D. M., Guilhamon, P., Bertrand, K. C., Mikael, L. G., McConechy, M. K., Chen, C., Khazaei, S., Koncar, R. F., Agnihotri, S., Faury, D., Ellezam, B., Weil, A. G., Urisini-Siegel, J., De Carvalho, D. D., Dirks, P. B., Lewis, P. W., Salomoni, P., Lupien, M., Arrowsmith, C., Lasko, P. F., Garcia, B. A., Kleinman, C. L., Jabado, N., and Mack, S. C. (2019) Pervasive H3K27 acetylation leads to ERV expression and a therapeutic vulnerability in H3K27M gliomas. Cancer Cell 35: 782-797. PMID 31085178.

 

134. Berlandi, J., Chaouch, A., De Jay, N., Tegeder, I., Thiel, K., Shirinian, M., Kleinman, C., Jeibmann, A., Lasko, P., Jabado, N., and Hasselblatt, M. (2019) Identification of genes functionally involved in the detrimental effects of mutant histone H3.3-K27M in Drosophila melanogaster. Neuro-Oncology, 21: 628-639. PMID 30715493.

 

133. Oriel, C. and Lasko, P. (2018) Recent developments in using Drosophilaas a model for human genetic disease. Int. J. Mol. Sci.19: E2041. PMID 30011838.

 

132. Dawkins, H. J. S., Draghia-Akli, R., Lasko, P., Lau, L. P. L., Jonker, A. H., Cutillo, C. M., Rath, A., Boycott, K. M., Baynam, G., Lochmüller, H., Kaufmann, P., LeCam, Y., Hivert, V., and Austin, C. P. (2018) Progress in rare diseases research 2010-2016: an IRDiRC perspective. Clin. Translat. Sci 11: 11-20. PMID 28796411.

 

131. Baynam, G., Bowman, F., Lister, K., Walker, C. E., Pachter, N., Goldblatt, J., Boycott, K. M., Gahl, W. A., Kosaki, K., Adachi, T., Ishii, K., Mahede, T., McKenzie, F., Townshend, S., Slee, J., Kiraly-Borri, C., Vasudevan, A., Hawkins, A., Broley, S., Schofield, L., Verhoef, H., Groza, T., Zankl, A., Robinson, P. N., Haendel, M., Brudno, M., Mattick, J. S., Dinger, M. E., Roscioli, T., Cowley, M. J., Olry, A., Hanauer, M., Alkuraya, F. S., Taruscio, D., Posada de la Paz, M., Lochmüller, H., Bushby, K., Thompson, R., Hedley, V., Lasko, P., Mina, K., Beilby, J., Tifft, C., Davis, M., Laing, N. G., Julkowska, D., Le Cam, Y., Terry, S. F., Kaufmann, P., Eerola, I., Norstedt, I., Rath, A., Suematsu, M., Groft, S. C., Austin, C. P., Draghia-Akli, R., Weeramanthri, T. S., Molster, C., and Dawkins, H. J. S. (2017) Improved diagnosis and care for rare diseases through implementation of precision public health framework. Adv. Exp. Med. Biol.1031: 55-94. PMID 29214566.

 

130. Lochmüller, H., Torrent i Farnell, J., LeCam, Y., Jonker, A.H., Lau, L.P.L., Baynam, G., Kaufmann, P., Dawkins, H.J.S., Lasko, P., Austin, C., and Boycott, K. M. (2017) The International Rare Diseases Research Consortium: policies and guidelines to maximize impact. Eur. J. Hum. Genet.25: 1293-1302. PMID 29158551.

 

129. Richer, E., Lasko, P., Robbins, S., and Syme, R. (2017) The Canadian path from discovery to the implementation of personalized medicine approaches. Biomed. Hub, 2(suppl. 1): 479487. doi 10.1159/000479487.

 

128. Lasko, P. (2017) mRNAs on the move after lunch. Dev. Cell42: 439-440. PMID 28898674

 

127. Dehghani, M. and Lasko, P. (2017) Multiple functions of the DEAD-box helicase Vasa in Drosophilaoogenesis. Results Probl. Cell Differ. 63: 127-147. PMID 28779316.

 

126. Lasko, P. (2017) Dueling RNA-binding proteins promote translational activation. Nature Struct. Mol. Biol.24: 609-610. PMID 28771463.

 

125. Baynam, G., Broley, S., Bauskis, A., Pachter, N., McKenzie, F., Townshend, S., Slee, J., Kiraly-Borri, C., Vasudevan, A., Hawkins, A., Schofield, L., Helmholz, P., Palmer, R., Kung, S., Walker, C. E., Molster, C., Lewis, B., Mina, K., Beilby, C., Pathak, G., Poulton, C., Groza, T., Zankl, A., Roscioli, T., Dinger, M. E., Mattick, J. S., Gahl, W., Groft, S., Tifft, C., Taruscio, D., Lasko, P., Kosaki, K., Wilhelm, H., Melegh, B., Carapetis, J., Jana, S., Chaney, G., Johns, A., Owen, P. W., Daly, F., Weeramanthri, T., Dawkins, H., and Goldblatt, J. (2017) Initiating an undiagnosed diseases program in the Western Australian public health system. Orphanet J. Rare Dis.12(1); 83. PMID 28468665.

 

124. Anderson, W., Apweiler, R., Bateman, A., Bauer, G. A., Berman, H., Blake, J. A., Blomberg, N., Burley, S. K., Cochrane, G., DiFrancesco, V., Donohue, T., Durinx, C., Game, A., Green, E., Gojobori, T., Goodhand, P., Hamosh, A., Hermjakob, H., Kanehisa, M., Kiley, R., McEntyre, J., McKibbin, R., Miyano, S., Pauly, B., Perrimon, N., Richards, G., Teo, Y.-Y., Westerfield, M., Westhof, E., and Lasko, P. F. (2017) Towards coordinated international support of core data resources for the life sciences. Preprint at bioRxiv, https://doi.org/10.1101/110825.

 

123. Anderson, W., Apweiler, R., Bateman, A., Bauer, G. A., Berman, H., Blake, J. A., Blomberg, N., Burley, S. K., Cochrane, G., DiFrancesco, V., Donohue, T., Durinx, C., Game, A., Green, E., Gojobori, T., Goodhand, P., Hamosh, A., Hermjakob, H., Kanehisa, M., Kiley, R., McEntyre, J., McKibbin, R., Miyano, S., Pauly, B., Perrimon, N., Richards, G., Teo, Y.-Y., Westerfield, M., Westhof, E., and Lasko, P. F.  (2017) Data management: a global coalition to sustain core data. Nature543: 179. PMID 28277502.

 

122. Stunnenberg, H. G., International Human Epigenome Consortium, [228 collaborators including Lasko, P.], and Hirst, M. (2016) The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery. Cell 167: 1145-1149. PMID 27863232

 

121. Boycott, K., Lochmüller, H., LeCam, Y., Jonker, A. H., Lau, L. P. L., Baynam, G., Kaufmann, P. Lasko, P., Dawkins, H. J., and Austin, C. P. (2016) “IRDiRC recognized resources”—a new mechanism to support scientists to conduct efficient, high-quality research for rare diseases. Eur. J. Hum. Genet. 25: 162-165. PMID 27782107

 

120. Dehghani, M. and Lasko, P. (2016) C-terminal residues specific to Vasa among DEAD-box helicases are required for its functions in piRNA biogenesis and embryonic patterning. Dev. Genes Evol. 226: 401-412. PMID 27572922

 

119. Marygold, S. J., Attrill, H., and Lasko, P. (2016) The translation factors of Drosophila melanogaster. Fly11: 65-74. PMID 27494710

 

118. Kowanda, M., Bergalet, J., Wieczorek, M., Brouhard, G., Lécuyer, É., and Lasko, P. (2016) Loss of function of the Drosophila Ninein-related centrosomal protein Bsg25D causes mitotic defects and impairs embryonic development. Biol. Open5: 1040-1051. PMID 27422905

 

117. Valzania, L., Ono, H., Ignesti, M., Cavaliere, V., Bernardi, F., Gamberi, C., Lasko, P., and Gargiulo, G. (2016) Drosophila 4EHP is essential for the larval-pupal transition and required in the prothoracic gland for ecdysone biosynthesis. Dev. Biol.410: 14-23. PMID 26721418

 

116. Taruscio, D., Groft, S., Cederroth, H., Melegh, B., Lasko, P., Kosaki, K., Baynam, G., and Gahl, W. (2015) Undiagnosed Diseases Network International (UDNI): White paper for global actions to meet patient needs. Mol. Genet. Metab.116: 223-225. PMID 26596705

 

115. Manolio, T. A., Abramowicz, M., Al-Mulla, F., Anderson, W., Balling, R., Berger, A. C., Bleyl, S., Chakravarti, A., Chantratita, W., Chisholm, R. L., Dissanayake, V. H. W., Dunn, M., Dzau, V. J., Han, B. G., Hubbard, T., Kolbe, A., Korf, B., Kubo, M., Lasko, P., Leego, E., Mahasirimongkol, S., Majumdar, P. P., Matthijs, G., McLeod, H. L., Metspalu, A., Meulien, P., Miyamo, S., Naparstek, Y., O’Rourke, P. P., Patrinos, G. P., Rehm, H. L., Relling, M. V., Rennert, G., Rodrigues, L. L., Roden, D. M., Shuldiner, A. R., Sinha, S., Tan, P., Ulfendahl, M., Ward, R., Williams, M. S., Wong, J. E. L., Green, E. D., and Ginsburg, G. S. (2015) Global implementation of genomic medicine: we are not alone. Science Translat. Med.7 (290): 290ps13. PMID 26041702

 

114. Liu, N. and Lasko, P. (2015) Analysis of RNA interference lines identifies new maternally-expressed genes involved in embryonic patterning in Drosophila melanogaster. G3-Genes, Genomes, Genetics 5: 1025-1034. PMID 25834215

 

113. Ghosh, S. and Lasko, P. (2015) Loss-of-function analysis reveals distinct requirements of the translation initiation factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophilaspermatogenesis. PLoS ONE10(4): e0122519. PMID 25849588

 

112. Dehghani, M. and Lasko, P. (2015) In vivo mapping of functional regions of the DEAD-box helicase Vasa. Biol. Open4: 450-462. PMID 25795910

 

111. Gao, M., Thomson, T. C., Creed, T. M., Tu, S., Loganathan, S. N., Jackson, C. A., McCluskey, P., Lin, Y., Collier, S. E., Weng, Z., Lasko, P., Ohi, M. D., and Arkov, A. L. (2015) Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements. EMBO Rep. 16: 379-386. PMID 25600116

 

110. Ivshina, M., Lasko, P., and Richter, J. D. (2014) Cytoplasmic polyadenylation element binding proteins in development, health, and disease. Ann. Rev. Cell Dev. Biol. 30: 393-415. PMID 25068488

 

109. Almouzni, G., Altucci, L., Amati, B., Ashley, N., Baulcombe, D., Beaujean, N., Bock, C., Bongcam-Rudloff, E., Bousquet, J., Braun, S., Paillerets, B.B., Bussemakers, M., Clarke, L., Conesa, A., Estivill, X., Fazeli, A., Grgurević, N., Gut, I., Heijmans, B.T., Hermouet, S., Houwing-Duistermaat, J., Iacobucci, I., Ilaš, J., Kandimalla, R., Krauss-Etschmann, S., Lasko, P., Lehmann, S., Lindroth, A., Majdič, G., Marcotte, E., Martinelli, G., Martinet, N., Meyer, E., Miceli, C., Mills, K., Moreno-Villanueva, M., Morvan, G., Nickel, D., Niesler, B., Nowacki, M., Nowak, J., Ossowski, S., Pelizzola, M., Pochet, R., Potočnik, U., Radwanska, M., Raes, J., Rattray, M., Robinson, M.D., Roelen, B., Sauer, S., Schinzer, D., Slagboom, E., Spector, T., Stunnenberg, H.G., Tiligada, E., Torres-Padilla, M.E., Tsonaka, R., Soom, A.V., Vidaković, M., and Widschwendter, M. (2014) Relationship between genome and epigenome –challenges for future research. BMC Genomics15 : 487. PMID 24942464

 

108. MacLeod, S., Lasko, P., and MacKenzie, A. (2014) The study of drugs for rare disorders: harnessing research contributions by Canadian academic institutions. J. Popul. Therapeut. Clin. Pharmacol. 21: e47-e55. PMID 24671865

 

107. Meulien, P., Lasko, P., MacKenzie, A., Bell, C., and Boycott, K. (2014) Rare diseases—how genomics has transformed thinking, diagnoses, and hope for affected families. In Bali, R. K., et al., eds., Orphan Diseases in the Age of Health 2.0, Berlin: Springer-Verlag, pp. 27-38.

 

106. Solana, J., Gamberi, C., Mihaylova, Y., Grosswendt, S., Chen, C., Lasko, P., Rajewsky, N., and Aboobaker, A. A. (2013) The CCR4-NOT complex mediates deadenylation and degradation of stem cell mRNAs and promotes planarian stem cell differentiation. PLoS Genet. 9(12) e1004003. PMID 24367277

 

105.Lasko, P. (2013) The DEAD-box helicase Vasa: evidence for a multiplicity of functions in RNA processes and developmental biology. BBA-Gene Regulatory Mechanisms1829: 810-816. PMID 23587717

 

104. Hernández, G., Miron, M., Han, H., Liu, N., Magescas, J., Tettweiler, G., Frank, F., Siddiqui, N., Sonenberg, N., and Lasko, P. (2013) Mextli is a novel eIF4E binding protein that promotes translation in Drosophila.Mol. Cell. Biol.33: 2854-2864. PMID 23716590

 

103.Lasko, P. (2013) New wrinkles on genetic control of the MBT.Curr. Biol.23: R65-R67. PMID 23347940

 

102. Gkogkas, C. G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D. B., Vasuta, C., Yee, S., Paul, D., Truitt, M., Major, F., Lasko, P., Ruggero, D., Nader, K., Lacaille, J.-C., and Sonenberg, N. (2013) Autism-related defects via dysregulated eIF4E-dependent translational control. Nature 493: 371-377. PMID 23172145

 

101. Hernández, G., Han, H., Gandin, V., Fabian, L., Ferreira, T., Zuberek, J., Sonenberg, N., Brill, J. A., and Lasko, P. (2012) Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis, and male fertility in Drosophila. Development 139: 3211-3220. PMID 22833128

 

100.Lasko, P. (2012) mRNA localization and translational control in Drosophila oogenesis. Cold Spring Harb. Perspect. Biol.4(10): a012294. PMID 22865893

 

99. Tettweiler, G., Kowanda, M., Lasko, P., Sonenberg, N., and Hernández, G. (2012) The distribution of eIF4E-family members across Insecta. Comp. Func. Genomics.2012: 960420 (15 pages). PMID 22745595

 

98. Gamberi, C. and Lasko, P. (2012) The Bic-C family of developmental translational regulators. Comp. Func. Genomics.2012: 141386 (23 pages). PMID 22611335

 

97. Kong, J. and Lasko. P. (2012) Translational control in cellular and developmental processes. Nature Rev. Genet.13: 383-394. PMID 22568971

 

96. Richter, J. and Lasko, P. (2011) Translational control in oocyte development. Cold Spring Harb. Perspect. Biol.3(9): a002758. PMID 21690213

 

95. Parsyan, A., Svitkin, Y., Shahbazian, D., Gkogkas, C., Lasko, P., Merrick, W., and Sonenberg, N. (2011) mRNA helicases—the tacticians of translational control. Nature Rev. Mol. Cell Biol 12: 235-245. PMID 21427765

 

94.Lasko, P. (2011) Post-transcriptional regulation in Drosophila oocytes and early embryos. Wiley Interdisciplinary Reviews2: 408-416. PMID 21957026

 

93.Lasko, P. (2010) Tudor domain. Curr. Biol. 20: R666-R667. PMID 20728048

 

92. Kugler, J.-M., Lem, C., and Lasko, P. (2010) Reduced cul-5activity causes aberrant follicular morphogenesis and germ cell loss in Drosophila. PLoS ONE5(2): e9048. PMID 20140218

 

91. Kugler, J.-M., Woo, J.-S., Oh, B.-H., and Lasko, P. (2010) Competitive regulation of Drosophila Vasa in vivo through paralogous Cullin-RING E3 ligase specificity receptors. Mol. Cell. Biol.30: 1769-1782. PMID 20123973

 

90. Kirino, Y., Vourekas, A., Sayed, N., de Lima Alves, F., Thomson, T., Lasko, P., Rappsilber, J., Jongens, T. A., and Mourelatos, Z. (2010) Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA16: 70-78. PMID 19926723

 

89. Hernández, G., Altmann, M., and Lasko, P. (2010) The origins and evolution of the mechanisms regulating translation initiation in eukaryotes. Trends Biochem.35: 63-73. PMID 19926289

 

88. Liu, N., Han, H., and Lasko, P. (2009) Vasa promotes Drosophilagerm line stem cell differentiation by activating mei-P26translation through a direct interaction with a U-rich motif in its 3’ UTR. Genes Dev.23: 2742-2752. PMID 19952109

 

87. Kilfoil, M., Lasko, P., and Abouheif, E. (2009) Stochastic variation: from single cells to superorganisms. HFSP J. 3: 379-385. PMID 20514130

 

86. Lasko, P. (2009) Translational control during early development. In Translational Control in Health and Disease. (Hershey, J. W., ed.), vol. 90 of Progress in Molecular Biology and Translational Science. Burlington: Academic Press, p. 211-254. PMID 20374743

 

85. Maurizil, M., Cavaliere, V., Gamberi, C., Lasko, P., Gargiulo, G., and Taddei, C. (2009) Vasa protein is localized in the germ cells and in the oocyte associated pyriform follicle cells during early oogenesis in the lizard Podarcis sicula. Dev. Genes Evol.219: 361-367. PMID 19609556

 

84. Pare, J. M., Tahbaz, N., LaPointe, P., Lasko, P., and Hobman, T. C. (2009) Hsp90 regulates the function of Argonaute proteins and their recruitment to stress granules and P-bodies. Mol. Biol. Cell20: 3273-3284. PMID 19458189

 

83. Moore, J., Han, H., and Lasko, P. (2009) Bruno negatively regulates germ cell-lessexpression in a BRE-independent manner. Mech. Dev. 126: 503-516. PMID 19393317

 

82. Moore, J. and Lasko, P. (2009) Breaking the A chain: regulating mRNAs in development through CCR4 deadenylase. F1000 Biology Reports1: 20. PMID 20948665

 

81. Kugler, J.-M. and Lasko, P. (2009) Localization, anchoring, and translational control of oskar, gurken, bicoid, and nanosmRNA during Drosophila oogenesis. Fly3: 15-28. PMID 19182536

 

80.Solana, J., Lasko, P., and Romero, R. (2009) Spoltud-1is a chromatoid body component required for planarian long-term stem cell self-renewal. Dev. Biol.328: 410-421. PMID 19389344

 

79.Kugler, J.M., Chicoine, J., and Lasko, P. (2009) Bicaudal-C associates with a Trailer Hitch/Me31B complex and is required for efficient Gurken secretion. Dev. Biol.328: 160-172.PMID 19389362

 

78. Moore, J. and Lasko, P. (2009) Translational control in invertebrate development. In Handbook of Cell Signaling(ed. N. Sonenberg; Academic Press, New York), pp. 2323-2328.

 

77. Stein, D. and Lasko, P. (2008) The 30thAnniversary Crete Fly Meeting: from individual molecules to 12 genomes, and beyond. Fly2: 326-333. PMID 19098434

 

76. Dansereau, D. A., and Lasko, P. (2008) RanBPM regulates cell shape, arrangement and capacity of the female germline stem cell niche in Drosophila melanogaster. J. Cell Biol. 182: 963-977. PMID 18762575

 

75. Thomson, T., Liu, N., Arkov, A., Lehmann, R., and Lasko, P. (2008) Isolation of new polar granule components in Drosophilareveals P body and ER associated proteins. Mech. Dev.125: 865-873. PMID 18590813

 

74. Hanyu-Nakamura, K., Sonobe, H., Tanigawa, A., Lasko, P., and Nakamura, A. (2008) Drosophila PGC protein inhibits p-TEFb recruitment to chromatin in primordial germ cells. Nature451: 730-733. PMID 18200011

 

73. Dansereau, D. A. and Lasko, P. (2008) The development of germline stem cells in Drosophila. In: Hou, S. X. and Singh, S. R. (eds.) Methods in Molecular Biology, volume 450, Germline Stem Cells. Totowa, NJ: Humana Press, p. 3- 26. PMID 18370048

 

72.Lasko, P. (2007) The Genetics Society of Canada takes a flight with Drosophilato celebrate its 50thyear. Fly1: 303-304. PMID 19098434

 

71.Chicoine, J., Benoit, P., Gamberi, C., Paliouras, M., Simonelig, M., and Lasko, P. (2007) Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression. Developmental Cell13: 691-704. PMID 17981137

 

70. Levitin, A., Laforest, M. J., Tettweiler, G., Oberholzer, U., Marcil, A., Alarco, A.-M., Thomas, D. Y., Lasko, P., and Whiteway, M. (2007) Drosophila melanogasterThor and response to Candida albicansinfection. Eukaryotic Cell6: 658-663. PMID 17277170

 

69.Lasko, P. and Sonenberg, N. (2007) Coordinated transcriptional and translational control in metabolic homeostasis in flies. Genes Dev. 21: 235-237. PMID 17289913

 

68. Tettweiler, G. and Lasko, P. (2007) Investigating translation initiation using Drosophila molecular genetics. Meth. Enzymol. 429: 227-242. PMID 17913626

 

67. Levine, S. L., Sunday, S., Dörig, R. E., Suter, B., and Lasko, P. (2007) Genetic maps of the proximal half of chromosome arm 2L of Drosophila melanogaster. Genome50: 137-141. PMID 17546078

 

66. Cho, P., Gamberi, C., Cho-Park, Y. A., Cho-Park, I. B., Lasko, P., and Sonenberg, N. (2006) Cap-dependent translational inhibition establishes two opposing morphogen gradients in the Drosophilaembryo. Curr. Biol. 16: 2035-2041. PMID 17055983

 

65. Tettweiler, G. and Lasko, P. (2006) A new model for translational regulation of specific mRNAs. Trends Biochem. Sci. 31: 607-610. PMID 17015016

 

64. Xing, Y., Gosden, R., Lasko, P., and Clarke, H. (2006) Murine homologues of the Drosophila gustavusgene are expressed in ovarian granulosa cells. Reproduction 131: 905-915. PMID 16672355

 

63. Linder, P. and Lasko, P. (2006) Bent out of shape: RNA unwinding by the DEAD-box helicase Vasa. Cell125: 219-221. PMID 16630807

 

62.Gamberi, C., Johnstone, O., and Lasko, P. (2006) DrosophilaRNA binding proteins. Int. Rev. Cytol.248: 43-139.PMID 16487790

 

61.Lasko, P., Cho, P., Poulin, F., and Sonenberg, N. (2005) Contrasting mechanisms of regulating translation of specific Drosophilagerm line mRNAs at the level of 5’ cap structure binding. Biochem. Soc. Trans.33: 1544-1546. PMID 16246166

 

60. Tettweiler, G., Miron, M., Jenkins, M., Sonenberg, N., and Lasko, P. (2005) Starvation and oxidative stress resistance in Drosophilaare mediated through eIF4E-binding protein. Genes Dev. 19: 1840-1843. PMID 16055649

 

59. Thomson, T. and Lasko, P. (2005) Tudor and its domains: germ cell formation from a Tudor perspective. Cell Research15: 281-291. PMID 15857583

 

58. Cho, P., Poulin, F., Cho-Park, Y. A., Cho-Park, I. B., Chicoine, J. D., Lasko, P. and Sonenberg, N. (2005) A new paradigm for translational control: inhibition of caudalvia 5’-3’ tethering by Bicoid and the eIF4E cognate 4EHP. Cell121: 411-423. PMID 15882623

 

57. Johnstone, O., Deuring, R., Bock, R., Linder, P., Fuller, M., and Lasko, P. (2005) Belle is a DrosophilaDEAD-box protein required for viability and in the germ line. Dev. Biol.277: 92-101. PMID 15572142

 

56. Dansereau, D. A., McKearin, D., and Lasko, P. (2005) Oogenesis. In Gilbert, L., Gill, S., and Iatrou, K. (eds.) Comprehensive Insect Physiology, Biochemistry, Pharmacology and Molecular Biology (Elsevier Press: Amsterdam), p. 39-85.

 

55. Thomson, T. and Lasko, P. (2004)Drosophila tudor is essential for polar granule assembly and pole cell specification, but not for posterior patterning. Genesis40: 164-170. PMID 15495201

 

54. Johnstone, O. and Lasko, P. (2004) Interaction with eIF5B is essential for Vasa function during development. Development131: 4167-4178. PMID 15280213

 

53. Schuetze, C., Akit-Peters, M., Duong, J.-J., Cavey, M., Dörig, R., Lasko, P., and Suter, B. (2004) Map positions of third chromosome female sterile and lethal mutations of Drosophila melanogaster. Genome47: 832-838. PMID 15499397

 

52. Boulanger, M.-C., Branscombe Miranda, T., Clarke, S., DiFruscio, M., Suter, B., Lasko, P., and Richard, S. (2004) Characterization of Drosophilaprotein arginine methyltransferases DART1 and DART4. Biochem. J.379: 283-289. PMID 14705965

 

51. Roy, G., Miron, M., Khaleghpour, K., Lasko, P., and Sonenberg, N. (2004) The DrosophilaPABP-interacting protein, dPaip2, is a novel effector of cell growth. Mol. Cell. Biol.24: 1143-1154. PMID 14729960

 

50. Miron, M., Lasko, P., and Sonenberg, N. (2003) Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila. Mol. Cell. Biol.23: 9117-9126. PMID 14645523

 

49.Lasko, P. (2003) Cup-ling oskarlocalization to translational control. J. Cell Biol.163: 1189-1191. PMID 14691130

 

48.Lasko, P. (2003) Ribosomes rule: translation, not transcription, is the primary target of two major intercellular signaling pathways. Dev. Cell5: 671-672. PMID 14602068

 

47. Liu, N., Dansereau, D. A., and Lasko, P. (2003) Fat Facets interacts with Vasa in the Drosophilapole plasm and protects it from degradation. Curr. Biol.13: 1905-1909. PMID 14588248

 

46.Lasko, P. (2003) Gene regulation at the RNA layer: RNA-binding proteins in intercellular signaling networks. Science STKE179: RE6. PMID 12709531

 

45. Huang, H., Paliouras, M., Rambaldi, I., Lasko, P., and Featherstone, M. (2003) Non-muscle myosin promotes cytoplasmic localization of PBX. Mol. Cell. Biol.23: 3636-3645. PMID 12724421

 

44. DiFruscio, M., Styhler, S., Wikholm, E., Boulanger, M.-C., Lasko, P., and Richard, S. (2003) kep1interacts genetically with dredd/Caspase-8: Kep1 regulates the balance of the dreddisoforms. Proc. Natl. Acad. Sci. USA100: 1814-1819. PMID 12563030

 

43.Lasko, P. (2003) Translational control in invertebrate development. In Handbook of Cell Signaling(ed. N. Sonenberg; Academic Press, New York), vol. 3, p. 327-330.

 

42. Styhler, S., Nakamura, A., and Lasko, P. (2002) VASA localization requires the SPRY-domain and SOCS-box containing protein, GUSTAVUS. Dev. Cell3: 865-876. PMID 12479811

 

41. Larocque, D., Pilotte, J., Chen, T., Cloutier, F., Massie, B., Pedraza, L., Couture, R., Lasko, P., Almazan, G., and Richard, S. (2002) Nuclear retention of MBP RNA in the quaking viablemice. Neuron36: 815-829. PMID 12467586

 

40. Lasko, P. (2002) Diabetic flies? Using Drosophila melanogasterto understand the causes of monogenic and genetically complex diseases. Clin. Genet. 62: 358-367. PMID 12431248

 

39. Lachance, P. E. D., Miron, M., Raught, B., Sonenberg, N. and Lasko, P. (2002) Phosphorylation of eukaryotic initiation factor 4E (eIF4E) is critical for growth. Mol. Cell. Biol.22: 1656-1663. PMID 11865045

 

38. Johnstone, O. and Lasko, P. (2001) Translational regulation and RNA localization in Drosophilaoocytes and embryos. Annu. Rev. Genet.35: 365-406. PMID 11700288

 

37. Miron, M., Verdú, J., Lachance, P. E. D., Birnbaum, M. J., Lasko, P., and Sonenberg, N. (2001) The translational inhibitor 4E-BP is an effector of PI3K/Akt signaling in Drosophila, and regulates cell growth. Nature Cell Biol.3: 596-601. PMID 11389445

 

36. Butler, H., Levine, S., Wang, X., Bonyadi, S., Lasko, P., Suter, B., and Dörig, R. (2001) Map position and expression of the genes in the 38 region of Drosophila. Genetics158: 1597-1614. PMID 11514449

 

35. Lasko, P. (2000) Drosophilaembryo: maternal interactions in specification of the anterior-posterior axis. Encyclopedia of Life Sciences, Macmillan, London, and published on-line on www.els.net.

 

34. Lasko, P. (2000) The Drosophilagenome: translation factors and RNA binding proteins. J. Cell Biol.150: F51-F56. PMID 10908586

 

33. Sigrist, S. J., Thiel, P. R., Reiff, D. F., Lachance, P., Lasko, P., and Schuster, C. M. (2000) Postsynaptic translation controls morphology and efficacy of Drosophilaneuromuscular junctions. Nature405: 1062-1065. PMID 10890448

 

32. Adams, M. D., Celniker, S. E., Holt, R. A., Evans, C. A., Gocayne,J. D., Amanatides, P. G., Scherer, S., Li, P. W., Galle, R. F., George, R. A., Hoskins, R. A., Lewis, S., Richards, S., Ashburner, M., Henderson, S. N., Wortman, J. R., Yandell, M. D., Zhang, Q., Chen, L. X., Brandon, R. C., Rogers, Y.-H. C., Blazej, R. G., Champe, M., Pfeiffer, B. D., Wan, K. H., Doyle, C., Baxter, E. G., Nelson, C. R., Gabor Miklos, G. L., Abril Ferrando, J. F., Agbayani, A., An, H.-J., Ballew, R. M., Basu, A., Baxendale, J., Bayraktaroglu, L., Beasley, E. M., Beeson, K. Y., Benos, P. V., Berman, B. P., Bhandari, D., Bolshakov, S., Borkova, D., Botchan, M. R., Bouck, J., Brokstein, P., Burtis, K. C., Busam, D., Butler, H., Cadieu, E., Cherry, J. M., Dahlke, C., Davies, P., de Pablos, B., Delcher, A., Deng, Z., Deslattes Mays, A., Dew, I., Dietz, S. M., Dodson, K., Doup, L., Downes, M., Dugan-Rocha, S., Dunkov, B. C., Dunn, P., Durbin, K. J., Evangelista, C. C., Ferraz, C., Fleischmann, W., Fosler, C., Gabrielian, A. E., Garg, N., Gelbart, W. M., Glasser, K., Glodek, A., Gong, F., Gorrell, J. H., Gu, Z., Guan, P., Harris, M., Harris, N. L., Harvey, D., Heiman, T. J., Helt, G., Hernandez,J. R., Houck, J., Houston, K. A., Howland, T. J., Kalush, F., Karpen, G. H., Ke, P., Kennison, J. A., Ketchum, K. A., Kimmel, B., Kodira, C. D., Kraft, C., Kravitz, S., Kulp, D., Lai, Z.,Lasko, P., Lei, Y., Levitsky, A. A., Li, J., Li, Z., Liang, Y., Lin, X., Liu, X., McIntosh, T. C., McPherson, D., Merkulov, G., Milshina, N. V., Mobarry, C., Morris, J., Moshrefi, A., Mount, S. M., Murphy, L., Muzny,D. M., Nelson, D. L., Nelson, D. R., Nixon, K., Nusskern, D. R., Pacleb, J. M., Palazzolo, M., Pan, S., Pollard, J., Reese, M., Reinert, K., Remington, K., Saunders, R. D. C., Shen, H., Shue, C., Sidén-Kiamos, I., Simpson, M., Skupski, M. P., Smith, T., Spradling, A. C., Stapleton, M., Sun, E., Sutton, G. G., Turner, R., Venter, E., Wang, A. H., Wang, X., Wang, Z.-Y., Wassarman, D. A., Weinstock, G. M., Woodage, T., Worley,K. C., Wu, D., Yang, S., Yao, A. Q., Ye, J., Zhan, M., Zhang, G., Zhao, Q., Zheng, E., Zheng, H. X., Zhong, F. N., Zhong,W., Zhou, X., Zhu, S., Zhu, X., Smith, H. O., Gibbs, R., Myers, G., Rubin, G. M., and Venter, J. C. (2000) The genome sequence of Drosophila melanogaster. Science287: 2185-2195. PMID 10731132

 

31. Carrera, P., Johnstone, O., Nakamura, A., Casanova, J., Jäckle, H., and Lasko, P. (2000) VASA mediates translation through interaction with a DrosophilayIF2 homolog. Mol. Cell5: 181-187. PMID 10678180

 

30. Saffman, E. E. and Lasko, P. (1999) Germ line development in vertebrates and invertebrates. Cell. Mol. Life Sci.55: 1141-1163. PMID 10442094

 

29. Lasko, P. (1999) RNA sorting in Drosophilaoocytes and embryos. FASEB J.13: 421-433. PMID 10064609

 

28. Lasko, P. (1999) Germ cell, line. In:Creighton, T. E., ed., The Encyclopedia of Molecular Biology, p. 1004-1006. John Wiley and Sons.

 

27. Kobayashi, S., Amikura, R., Nakamura, A., and Lasko, P. F. (1999) Techniques for analyzing protein and RNA distribution in Drosophilaovaries and embryos at structural and ultrastructural resolution. In:Richter, J., ed.,Advances in molecular biology: a comparative methods approach to the study of oocytes and embryos.Oxford University Press.

 

26. DiFruscio, M., Bonyadi, S., Lasko, P., and Richard, S. (1998) The identification of two DrosophilaKH domain proteins: KEP1 and SAM are members of the Sam68 family of GSG domain proteins. J. Biol. Chem.273: 30122-30130. PMID 9804767

 

25. Saffman, E. E., Styhler, S., Rother, K., Richard, S., and Lasko, P. (1998) Premature translation of oskarin oocytes lacking the RNA-binding protein, Bicaudal-C. Mol. Cell. Biol. 18: 4855-4862. PMID 9671494

 

24. Styhler, S., Nakamura, A., Swan, A., Suter, B., and Lasko, P. (1998) vasais required for GURKEN accumulation in the oocyte, and is involved in oocyte determination and germ line cyst development. Development125: 1569-1578. PMID 9521895

 

23. Webster, P. J., Liang, L., Berg, C. A., Lasko, P., and Macdonald, P. M. (1997) Translational repressor brunois widely conserved and plays multiple roles in development. Genes Dev. 11: 2510-2521. PMID 9334316

 

22. Chen, T., Damaj, B. B., Herrera, C., Lasko, P., and Richard, S. (1997) Members of the single KH domain family Sam68, GRP-33, GLD-1 and Qk1 self-associate: role of the KH domain. Mol. Cell. Biol.17: 5707-5718. PMID 9315629

 

21. Nakamura, A. and Lasko, P. F. (1997) New evidence for similarities in germ line formation among different animal groups. Experimental Medicine15: 921-923. (Review article in Japanese)

 

20. Eberl, D. F., Lorenz, L. J., Melnick, M. B., Sood, V., Lasko, P., and Perrimon, N. (1997) An enhancer of position-effect variegation inDrosophila melanogasterencodes a putative RNA helicase which binds chromosomes and is regulated by the cell cycle. Genetics 146: 951-963.
PMID 9215899

 

19. Nakamura, A., Amikura, R., Mukai, M., Kobayashi, S., and Lasko, P. F. (1996) Requirement for a non-coding RNA component of Drosophilapolar granules for germ cell establishment. Science274: 2075-2079. PMID 8953037

 

18. Lavoie, C. A., Lachance, P. E. D., Sonenberg, N., and Lasko, P. (1996) Alternatively spliced transcripts from the Drosophila eIF4Egene produce two different cap-binding proteins. J. Biol. Chem. 271: 16393-16398. PMID 8663200

 

17. Rafti, F., Scarvelis, D., and Lasko, P. F. (1996) A Drosophilamelanogasterhomologue of the human DEAD-box gene DDX1. Gene171: 225-229. PMID 8666277

 

16. Mahone, M., Saffman, E. E., and Lasko, P. F. (1995) Localized Bicaudal-CRNA encodes a protein containing a KH domain, the RNA binding motif of FMR1. EMBO J.14: 2043-2055. PMID 7538070

 

15.Lasko, P. (1995) Cell-cell signalling, microtubule organization, and RNA localization: is PKA a link? BioEssays17: 105-107. PMID 7538292

 

14. Liang, L., Diehl-Jones, W., and Lasko, P. F. (1994) Localization of vasa protein to the Drosophilapole plasm is independent of its RNA binding and helicase activities. Development120: 1201-1211. PMID 8026630

 

13. Lavoie, C., Tam, R., Clark, M., Lee, H., Sonenberg, N., and Lasko, P. (1994) Suppression of a temperature-sensitive cdc33mutation of yeast by a multicopy plasmid expressing a Drosophilaribosomal protein. J. Biol. Chem.269: 14625-14630. PMID 8182070

 

12.Lasko, P. F. (1994) Molecular genetics of Drosophilaoogenesis. Austin: R. G. Landes Company. 125 pp. (Book.)

 

11. Lavoie, C. A., Harvey, M., and Lasko, P. F. (1993) Dbp45Aencodes aDrosophilaD-E-A-D box protein with similarity to a putative yeast helicase involved in ribosome assembly. Biochim. Biophys. Acta1216: 140-144. PMID 7692973

 

10.Lasko, P. F. (1992) Molecular movements in oocyte patterning and pole cell differentiation. BioEssays14: 507-512. PMID 1365903

 

9. Patterson, L. F., Harvey, M. and Lasko, P. F. (1992) Dbp73D, a Drosophilagene expressed in ovary, encodes a novel D-E-A-D box protein. Nucleic Acids Res.20: 3063-3067. PMID 1620603

 

8. Lasko, P. F. and Ashburner, M. (1990) Posterior localization of vasaprotein correlates with, but is not sufficient for, pole cell development. Genes Dev.4: 905-922. PMID 2384213

 

7. Ashburner, M., Thomson, P., Roote, J., Lasko, P., Grau, Y., El Messal, M., Roth, S., and Simpson, P. (1990) The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. VII. Characterization of the region around the snailand cactusloci. Genetics126: 679-694. PMID 2123463

 

6. Wu, C.-t., Jones, R. S., Lasko, P. F., and Gelbart, W. M. (1989) Homeosis and the interaction of zesteand whitein Drosophila. Molecular and General Genetics218: 559-564. PMID 2511424

 

5. Aymé-Southgate, A., Lasko, P. F., French, C., and Pardue, M. L. (1989) Characterization of the gene for mp-20: a Drosophilamuscle protein that is not found in asynchronous oscillatory flight muscle. J. Cell Biol.108: 521-531. PMID 2537318

 

4. Linder, P., Lasko, P. F., Ashburner, M., Leroy, P., Nielsen, P. J., Nishi, K., Schnier, J. and Slonimski, P. (1989) Birth of the D–E–A–D box. Nature337: 121-122. PMID 2563148

 

3. Lasko, P. F. and Ashburner, M. (1988) The product of the Drosophilagene vasais very similar to eukaryotic initiation factor-4A. Nature335: 661-667. PMID 3140040

 

2. Lasko, P. F. and Pardue, M. L. (1988) Studies of the genetic organization of the vestigialmicroregion of D. melanogaster. Genetics120: 495-502. PMID 3143621

 

1. Lasko, P. F. and Brandriss, M. C. (1981) Proline transport in Saccharomyces cerevisiae. J. Bact.148: 241-247. PMID 7026531

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