McGill.CA / High-Throughput Screening Facility

Resources

Resources


Publications

  • Novac, O., Guenier, A.-S., and Pelletier, J. (2004). Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen. Nucl. Acids Res. 32, 902-915.
  • Itoh, A., Tanahashi, T., Nagakura, N., Takenaka, Y., Chen, C.-C., and Pelletier, J. (2004) Flavonoid glycosides from Adina racemosa and their inhibitory activities on eukaryotic protein synthesis. J. Nat. Prod. 67, 427-431.
  • Muhammad, I., Bedir, E., Khan, S.I., Tekwani, B.L. Khan, I.A., Takamatsu, S., Pelletier, J., and Walker, L.A. (2004). A new antimalaria quassinoid from Simaba orinocensis. J. Nat. Prod. 67, 772-777.
  • Kumar, R., Garneau, P., Nguyen, N., Lown, J.W., and Pelletier, J. (2004). Methionine substituted polyamides are RNAse mimics that inhibit translation. J. Drug. Target. 12, 125-134.
  • Fukamiya, N., Lee, K.-H., Muhammad, I., Murakami, C., Okano, M., Harvey, I., and Pelletier, J. (2005). Structure-activity relationships of quassinoids for eukaryotic protein synthesis. Canc. Lett. 220, 37-48.
  • Hamdan, F.F., Audet, M., Garneau, P., Pelletier, J., and Bouvier, M. (2005). High-throughput screening of G protein-coupled receptors antagonists using a BRET1-based b-arrestin2 recruitment assay. J. Biomolecular Screening. 10, 463-475.
  • Bordeleau, M.-E., Matthews, J., Wojnar, J.M., Lindqvist, L., Novac, O., Jankowsky, E., Sonenberg, N., Northcote, P., Teesdale-Spittle, P., and Pelletier, J. (2005) Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc. Natl. Acad. Sci. USA 102, 10460-10465.
  • Yan, Y., Svitkin, Y., Lee, J.M., Bisaillon, M., and Pelletier, J. (2005). Ribavirin is not a functional mimic of the 7-methyl guanosine mRNA cap. RNA 11, 1238-1244.
  • Zhao, HF., L'Abbe, D., Jolicoeur, N., Wu, M., Li, Z., Yu, Z., Shen, S.H. Related Articles, (2005). High-throughput screening of effective siRNAs from RNAi libraries delivered via bacterial invasion. Nat Methods. 2(12):967-73.
  • Bordeleau, M.-E., Mori, A., Oberer, M., Lindqvist, L., Higa, T., Belsham, G., Wagner, G., Tanaka, J., and Pelletier, J. (2006). Small Molecule Interference of Eukaryotic Translation Initiation Factor 4A RNA Binding Inhibits Translation. Nat. Chem. Biol. 2, 213-220.
  • Robert, F., Gao, H.Q., Donia, M., Merrick, W.C., Hamann, M.T., and Pelletier, J. (2006). Chlorolissoclimides: New inhibitors of eukaryotic protein synthesis. RNA 12, 717-724.
  • Malo, N., Hanley, J.A., Cerquozzi, S., Pelletier, J., and Nadon, R. (2006). Statistical practice in high-throughput screening data analysis. Nat. Biotech. 24, 167-175.
  • Mazroui, R., Sukarieh, R., Bordeleau, M.E., Kaufman, R.J., Northcote, P., Tanaka, J., Gallouzi, and Pelletier, J. (2006). Inhibition of ribosome recruitment induces stress granule formation independent of eIF2a phosphorylation. Mol. Biol. Cell. 17, 4212-4219.
  • Robert, F., Kapp, L.D., Khan, S.N., Acker, M.G., Kolitz, S., Kazemi, S., Kaufman, R.J., Merrick, W.C., Koromilas, A.E., Lorsch, J.R., and Pelletier, J. (2006). Initiation of protein synthesis by Hepatitis C virus is refractory to reduced eIF2•GTP•Met-tRNAiMet ternary complex availability. Mol. Biol. Cell. 17, 4632-44.
  • Bordeleau, M.E., Cencic, R., Lindqvist, L., Oberer, M., Northcote, P., Wagner, G., Pelletier, J. (2006). RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation. Chem Biol. 13, 1287-95.
  • Cencic, R., Yan, Y., and Pelletier, J. (2007). Homogenous Time Resolved Fluorescence Assay to Identify Modulators of Cap-dependent Translation Initiation. Comb Chem High Throughput Screen. 10, 181-8.
  • Carlile, G.W., Robert, R., Zhang, D.L., Teske, K.A., Luo, Y.S., Hanrahan, J. W., and Thomas, D.Y. (2007) Correctors of protein trafficking defects identified by a novel high-throughput screening assay. ChemBioChem. 8, 1012-102
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