Alumni

Academic Training
Ph.D (Genetics), 2010, Anhui Medical University, China)
M.D., 2004, Binzhou Medical University, (China)

Publications
1. Han JW*, Zheng HF*, Cui Y*, Sun LD, Ye DQ, Hu Z, Xu JH, Cai ZM, Huang W, Zhao GP, Xie HF, Fang H, Lu QJ, Xu JH, Li XP, Pan YF, Deng DQ, Zeng FQ, Ye ZZ, Zhang XY, Wang QW, Hao F, Ma L, Zuo XB, Zhou FS, Du WH, Cheng YL, Yang JQ, Shen SK, Li J, Sheng YJ, Zuo XX, Zhu WF, Gao F, Zhang PL, Guo Q, Li B, Gao M, Xiao FL, Quan C, Zhang C, Zhang Z, Zhu KJ, Li Y, Hu DY, Lu WS, Huang JL, Liu SX, Li H, Ren YQ, Wang ZX, Yang CJ, Wang PG, Zhou WM, Lv YM, Zhang AP, Zhang SQ, Lin D, Li Y, Low HQ, Shen M, Zhai ZF, Wang Y, Zhang FY, Yang S, Liu JJ, Zhang XJ. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet. 2009 Nov;41(11):1234-7. (These authors contributed equally to this work)
2. Chen JM*, Zheng HF*, Bei JX, Sun LD, Jia WH, Li T, Zhang FR, Seielstad M, Zeng YX, Zhang XJ, Liu JJ. Genetic Structure of the Han Chinese Population Revealed by Genome-wide SNP Variation, Am J Hum Genet. 2009 Dec;85(6):775-85. (These authors contributed equally to this work).
3. Zheng HF, Zhang C, Ni C, Zuo XB, Sun LD, Zhang Z, Lu WS, Xu SX, Han JW, Cheng H, Zhu KJ, Cheng YL, Yang S, Zhang FY, Zhang XJ A Single Nucleotide Polymorphism of MHC region is associated with Subphenotypes of Psoriasis in Chinese population. J Dermatol Sci. 2010 Jul;59(1):50-2.
4. Zhang C *, Zhu KJ *, Zheng HF *, Zhou FS, Cheng YL, Tang XF, Li M, Zhang FY 2, Sun LD 1,2, Fan X, Zuo XB, Yang S, Zhang XJ. The Effect of Overweight and Obesity on Psoriasis Patients in Chinese Han Population: a hospital-based study. Journal of the European Academy of Dermatology and Venereology. DOI: 10.1111/j.1468-3083.2010.03706.x (These authors contributed equally to this work)
5. Zhang XJ, Huang W, Yang S, Sun LD, Zhang FY, Zhu QX, Zhang FR, Zhang C, Du WH, Pu XM, Li H, Xiao FL, Wang ZX, Cui Y, Hao F, Zheng J, Yang XQ, Cheng H, He CD, Liu XM, Xu LM, Zheng HF, Zhang SM, Zhang JZ, Wang HY, Cheng YL, Ji BH, Fang QY, Li YZ, Zhou FS, Han JW, Quan C, Chen B, Liu JL, Lin D, Fan L, Zhang AP, Liu SX, Yang CJ, Wang PG, Zhou WM, Lin GS, Wu WD, Fan X, Gao M, Yang BQ, Lu WS, Zhang Z, Zhu KJ, Shen SK, Li M, Zhang XY, Cao TT, Ren W, Zhang X, He J, Tang XF, Lu S, Yang JQ, Zhang L, Wang DN, Yuan F, Yin XY, Huang HJ, Wang HF, Lin XY, Liu JJ. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet. 2009 Feb;41(2):205-10.
6. Zhang FR, Huang W, Chen SM, Sun LD, Liu H, Li Y, Cui Y, Yan XX, Yang HT, Rong-De Yang, Chu TS, Zhang C, Zhang L, Han JW, Yu GQ, Quan C, Yu YX, Zhang Z, Shi BQ, Zhang LH, Cheng H, Wang CY, Lin Y, Zheng HF, Fu XA, Zuo XB, Wang Q, Long H, Sun YP, Cheng YL, Tian HQ, Zhou FS, Liu HX, Lu WS, He SM, Du WL, Shen M, Jin QY, Wang Y, Low HQ, Erwin T, Yang NH, Li JY, Zhao X, Jiao YL, Mao LG, Yin G, Jiang ZX, Wang XD, Yu JP, Hu ZH, Gong CH, Liu YQ, Liu RY, Wang DM, Wei D, Liu JX, Cao WK, Cao HZ, Li YP, Yan WG, Wei SY, Wang KJ, Hibberd ML, Yang S, Zhang XJ, Liu JJ. Genome-wide Association Study of Leprosy. N Engl J Med. 2009 Dec 31;361(27):2609-18. Epub 2009 Dec 16.
7. Wang LD, Zhou FY, Li XM, Sun LD, Song X, Jin Y, Li JM, Kong GQ, Qi H, Cui J, Zhang LQ, Yang JZ, Li JL, Li XC, Ren JL, Liu ZC, Gao WJ, Yuan L, Wei W, Zhang YR, Wang WP, Sheyhidin I, Li F, Chen BP, Ren SW, Liu B, Li D, Ku JW, Fan ZM, Zhou SL, Guo ZG, Zhao XK, Liu N, Ai YH, Shen FF, Cui WY, Song S, Guo T, Huang J, Yuan C, Huang J, Wu Y, Yue WB, Feng CW, Li HL, Wang Y, Tian JY, Lu Y, Yuan Y, Zhu WL, Liu M, Fu WJ, Yang X, Wang HJ, Han SL, Chen J, Han M, Wang HY, Zhang P, Li XM, Dong JC, Xing GL, Wang R, Guo M, Chang ZW, Liu HL, Guo L, Yuan ZQ, Liu H, Lu Q, Yang LQ, Zhu FG, Yang XF, Feng XS, Wang Z, Li Y, Gao SG, Qige Q, Bai LT, Yang WJ, Lei GY, Shen ZY, Chen LQ, Li EM, Xu LY, Wu ZY, Cao WK, Wang JP, Bao ZQ, Chen JL, Ding GC, Zhuang X, Zhou YF, Zheng HF, Zhang Z, et al. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet. 2010 Aug 22. [Epub ahead of print]
8. He CF, Liu YS, Cheng YL, Gao JP, Pan TM, Han JW, Quan C, Sun LD, Zheng HF, Zuo XB, Xu SX, Sheng YJ, Yao S, Hu WL, Li Y, Yu ZY, Yin XY, Zhang XJ, Cui Y, Yang S. TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in Chinese Han population. LUPUS.
9. Zhang Z, Zhu KJ, Xu Q, Zhang XJ, Sun LD, Zheng HF, Han JW, Quan C, Zhang SQ, Cai LQ, Xu SX, Zuo XB, Cheng H, Yang S. The association of the BLK gene with SLE was replicated in Chinese Han. Arch Dermatol Res. 2010 Feb 4. [Epub ahead of print]
10. Zheng HF, Wang PG, Yang S, Zhang XJ. Molecular genetic advances of Peutz-Jeghers syndrome. International Journal of Genetics, 2008; 31(3), 227-229. (In Chinese)

Academic Training
Ph.D (Genetics), 2009, Fudan University, Shanghai, China
Thesis: Association study between HCC risk and polymorphisms of gene encoding carcinogen-metabolizing enzyme and genes in DNA repair pathway.

B.S.(Biological technology), 2003, Wuhan University, Wuhan, China
Thesis: Research of Apoptosis Induced by Mitomycin in CHO-K1 Cell Line and Effect on Cell Cycle.

Publications
1. Rui Li, Yao Zhao, Weiwei Fan, Hongyan Chen, Yuanyuan Chen, Yanhong Liu, /BOOKS Gong Chen, Keke Zhou, Fengping Huang, Ying Mao, Liangfu Zhou, Daru Lu, Yin Yao Shugart. Possible association between polymorphisms of human vascular endothelial growth factor A gene and susceptibility to glioma in a Chinese population. Int J Cancer, 10.1002/ijc.25306.
2. Rui Li et al. Genetic polymorphisms in double-strand break DNA repair genes XRCC5, XRCC6 and susceptibility to hepatocellular carcinoma. In preparation.
3. Yuan Yang, Yun Zhou, Ming Lu, Yu An, Rui Li, Yao Chen, Xiao-yan Liu, Da-ru Lu , Li Jin, Wei-ping Zhou, Ji Qian, Hong-yang Wang. Fibroblast Growth Factor Receptor 4 Polymorphisms Associated with the Risk of Hepatocellular Carcinoma in Patients with Aggressive Progression. Liver Int, Under review.
4. Rui Li, Yin Yao Shugart, Weiping Zhou, Yu An, Yuan Yang, Yun Zhou, Beibei Zhang, Daru Lu, Hongyang Wang, Ji Qian, Li Jin. Common genetic variations of the cytochrome P450 1A1 gene and risk of hepatocellular carcinoma in a Chinese population. Eur J Cancer, 2009 May;45(7):1239-47.
5. Wenqing Fu, Yi Wang, Ying Wang, Rui Li, Rong Lin, Li Jin. Missing call bias in high-throughput genotyping. BMC Genomics. 2009 Mar 13;10:106.
6. Ji Qian, Jianying Jing, Guangfu Jin, Haifeng Wang, Yi Wang, Hongliang Liu, Haijian Wang, Rui Li, Weiwei Fan, Yu An, Weiwei Sun, Yi Wang, Hongxia Ma, Ruifeng Miao, Zhibin Hu, Li Jin, Qingyi Wei, Hongbing Shen, Wei Huang, Daru Lu. Association between polymorphisms in the GSTA4 gene and risk of lung cancer: A case-control study in a Southeastern Chinese population. Mol Carcinog, 2009 Mar;48(3):253-9.
7. Yu An, Guangfu Jin, Haifeng Wang, Yi Wang, Hongliang Liu, Rui Li, Haijian Wang, Ji Qian, Weiwei Sun, Yi Wang, Hongxia Ma, Ruifeng Miao, Zhibin Hu, Li Jin, Qingyi Wei，Hongbing Shen, Wei Huang, Daru Lu. Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population. Lung Cancer, 2008 Feb;59(2):164-70. Epub 2007 Sep 17.
8. Yanhong Liu, Haishi Zhang, Keke Zhou, Lina Chen, Zhonghui Xu, Yu Zhong, Hongliang Liu, Rui Li, Yin Yao Shugart, Qingyi Wei, Li Jin, Fengping Huang, Daru Lu and Liangfu Zhou. Tagging SNPs in Nonhomologous End-Joining Pathway Genes and Risk of Glioma. Carcinogenesis, 2007. 28(9): 1906-13.
9. Yin Yao Shugart, Lina Chen , Rui Li, Terri Beaty. Family-based linkage disequilibrium tests using general pedigrees. Methods Mol Bio, 2007. 376: 141-9.
10. Rui Li, Yi Xiong, Hongying Chen, Congyi Zheng, Sanfu Qu. Reseach of Apoptosis Induced by Mytomycin in CHO-K1 Cell Line and Effect on Cell Cycle. Journal of Wuhan University (Natural Science Edition), 2004. 50(2):251-5. In Chinese.

Academic Training
Ph.D (Genetics), 2009, McGill University, (Montréal, Québec)
M.D., 1997, Mashhad University, (Mashhad, Iran)

Publications
1. Iatan I, Dastani Z, Do R, Weissglas-Volkov D, Ruel I, Lee JC, Huertas-Vazquez A, Taskinen MR, Prat A, Seidah NG, Pajukanta P, Engert JC, Genest J.Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. Circ Cardiovasc Genet. 2009 Oct;2(5):467-75. Epub 2009 Aug 22.
2. Dastani Z, Pajukanta P, Marcil M, Rudzicz N, Ruel I, Bailey SD, Lee JC, Lemire M, Faith J, Platko J, Rioux J, Hudson TJ, Gaudet D, Engert JC, Genest J.Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. Eur J Hum Genet. 2010 Mar;18(3):342-7. Epub 2009 Oct 21.
3. Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greevenbroek MM, Kane JP, Malloy MJ, Pullinger CR, Huertas-Vazquez A, Aguilar-Salinas CA, Tusie-Luna T, de Bruin TW, Aouizerat BE, van der Kallen CC, Croce CM, Aqeilan RI, Marcil M, Viikari JS, Lehtimäki T, Raitakari OT, Kuusisto J, Laakso M, Taskinen MR, Genest J, Pajukanta P.WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels. Am J Hum Genet. 2008 Aug;83(2):180-92.
4. Dastani Z, Ruel IL, Engert JC, Genest J Jr, Marcil M. Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol.BMC Med Genet. 2007 Dec 18;8:79.
5. Dastani Z, Engert JC, Genest J, Marcil M.Genetics of high-density lipoproteins. Curr Opin Cardiol. 2006 Jul;21(4):329-35. Review.
6. Marcil M, Vu H, Cui W, Dastani Z, Engert JC, Gaudet D, Castro-Cabezas M, Sniderman AD, Genest J Jr, Cianflone K.Identification of a novel C5L2 variant (S323I) in a French Canadian family with familial combined hyperlipemia. Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1619-25. Epub 2006 Apr 20.
7. Dastani Z, Quiogue L, Plaisier C, Engert JC, Marcil M, Genest J, Pajukanta P.Evidence for a gene influencing high-density lipoprotein cholesterol on chromosome 4q31.21. Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):392-7. Epub 2005 Dec 1.
8. Dastani Z, Dangoisse C, Boucher B, Desbiens K, Krimbou L, Dufour R, Hegele RA, Pajukanta P, Engert JC, Genest J, Marcil M. A novel nonsense apolipoprotein A-I mutation (apoA-I(E136X)) causes low HDL cholesterol in French Canadians. Atherosclerosis. 2006 Mar;185(1):127-36. Epub 2005 Jul 14.

Academic Training
Ph.D (biostatistics), 2009, McGill University, (Montréal, Québec)
Ph.D thesis title: Diagnostic test results investigation using Bayesian nonparametric

Master of Science (biostatistics), 2004, McGill University, (Montréal, Québec)
Master’s thesis title: Prevalence estimation from imperfect databases using latent class Bayesian analysis.

Bachelor of Science specialized in mathematics (Statistics), 2002, Université de Montréal, (Montréal, Québec)

ERASMUS Faculté des sciences du Languedoc (Statistics), 2001,
Université de Montpellier II, (Montpellier, France)
Exchange program under CREPUQ

Publications
1. Maltais S., Forcillo J., Bouchard D., Carrier M., Cartier R., Demers P., Perrault L., Poirier N., Ladouceur M., Page P., and Pellerin M. Long-term Results following Concomitant radiofrequency modified Maze ablation for atribial fibrillation. Journal of Cardiac Surgery. April 2010.
2. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Streeten EA, Ohlsson C, Berry D, Florez J, Koller DL, Jrvelin MR, Cooper JD, O'Reilly P, Glazer NL, Vandenput L, Peacock M, Houston DK, Shi J, Rivadeneira F, McCarthy M, Anneli P, de Boer IH, Mangino M, Kato B, Smyth DJ, Booth SL, Jacques PF, Burke GL, Goodarzi M, Cheung CL, Wolf M, Rice K, Goltzman D, Hiridigolou N, Ladouceur M, Hui SL, Wareham NJ, Hocking LJ, Hart D, Arden N, Cooper C, Zhai G, Macdonald H, Forouhi NG, Loos RJF, Reid DM, Hakim A, Dennison E, Liu Y, Power C, Stevens H, Jaana L, Vasan RS, Soranzo N, Bojunga J, Psaty BM, Lorentzon M, Foroud T, Harris TB, Hofman A, Karasik D, Jansson JO, Uitterlinden AG, Cauley JA, Gibson Q, Palotie L, Siscovick DS, Kiel D, Econs MJ, Kritchevsky SB, Hypponen E, Dupuis J, Todd JA, Spector TD. Identification of genetic susceptibility loci for vitamin D insufficiency: the SUNLIGHT consortium. LANCET. April 2010.
3. Goh CC, Ladouceur M, Peters L, Desmond C, Tchervenkov J, Baran D. Lengthy cold ischemia time is a modifiable risk factor associated with low glomerular _ltration rates in expanded criteria donor kidney transplant recipients. Transplantation Proceedings. 2009; Oct;41(8): 3290-2.
4. Maltais S, Ibrahim R, Carrier M, Bouchard D, Cartier R, Ladouceur M, Pellerin, Perrault LP. Post-Infarction ventricular septal defects: Towards a new treatment algorithm? The annals of thoracic surgery 2009; 87: 687-692.
5. Skrutkowski M, Saucier A, Eades M, Swidzinski M, Ritchie J, Marchionni C, Ladouceur M. Impact of a Pivot Nurse in Oncology on Patients with Lung or Breast Cancer: Symptom Distress, Fatigue, Quality of Life, and Use of Health Care Resources. Oncology Nursing Forum 2008; 35(6): 948-54.
6. Ladouceur M, Rahme E, Pineau C, Joseph L. Robustness of prevalence estimates derived from misclassified data from administrative databases. Biometrics 2007; 63:272-279.
7. Al-Sabah S, Ladouceur M, Christou N. Anastomotic Leaks after Bariatric Surgery: it is the host response that matters. Surgery for Obesity and Related Diseases 2008 Mar-Apr; 4(2): 152-7.
8. Cantarovich M, Durrbach A, Hiesse Ch, Ladouceur M, Benoit G, Charpentier B. 20-year follow-up results of a randomized controlled trial comparing anti-lymphocyte globulin-induction to no induction in renal transplant patients. Transplantation. 2008. 86(12): 1732-1737.
9. Ladouceur, M, Technical member group Badley, E., DesMeules, M (eds). (2003) Arthritis in Canada: An Ongoing Challenge. Ottawa: Health Canada, 2003 (No de cat. #H39-4/14-203F) Direction générale de la santé de la population et de la santé publique. 1-137.

Academic Training
Endocrinology Fellowship training, Aug 2010-Current, McGill University Health Center
Internal Medicine Residency training, July 2006-June 2009, Jewish General Hospital, McGill University
Medicine (MD Program) Aug 2003-May 2006, University of Calgary
Masters of Science Sept 2000-Oct 2002, Department of Human Genetics, McGill University
Bachelor of Science (Honors Program), Molecular Genetics, Sept 1996-April 2000, University of Alberta

Publications
1)“Overexpression of RET leads to vesico-ureteric reflux in mice.” O. H. Yu, I.J. Murawski, D. Myburgh, and I.R. Gupta, American Journal of Physiology Renal Physiology.  2004; 287:F1123-1130.
2)“Morphogenesis during mouse embryonic kidney explant culture.” I.R. Gupta, M. Lapointe, O. H. Yu, Kidney International. 2003; 63(1): 365-76.
3)“Secrets of Medicine from Ancient Egypt.”  O. Yu and S. Wong, History of Medicine Days.  2004; p. 8-16.
4)“A novel strategy for identifying mutations that sensitize Drosophila eye development to caffeine and hydroxyurea.” E.A.Silva, B.J. Lee, L.S. Caceres, D. Renouf, B.R. Vilay, O. Yu, J.A. Bradley and S.D. Campbell, Genome. 2006; 49(11):1416-27. 
5)“Articular aspergillosis: case report and review of the literature.” Yu, O.H., Keet A.W., Sheppard, D.C., Brewer, T., International Journal of Infectious Disease. 2010; 14(5): e433-435.