Sébastien This
Academic title(s):
Assistant Professor
Branch:
Université de Sherbrooke
Department:
Immunology and Cell Biology
Areas of expertise:
- T cell immunity
- Intracellular signaling
- Microscopy and image analysis
- Biophotonics
- Machine-learning
Biography:
Sébastien This obtained his PhD in Immunology from the École Normale Supérieure de Lyon in France before moving to Canada for postdoctoral training. At Université de Montréal and McGill University, he worked at the intersection of immunology, biophysics, and machine learning, with a focus on improving adoptive T cell therapies. His research has centered on developing methods to monitor T cell receptor (TCR) signalling dynamics in activated CD8 T cells to predict antigen specificity and antigen affinity at the single-cell level. He also developed ART-CLaP, a laser-based technology that identifies T cells based on intracellular calcium dynamics, enabling downstream single-cell TCR sequencing.
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