Laboratory Facilities

Protein Expression and Purification

• Incubator shakers (including refrigerated shakers)
• Various centrifuges
• Gravity and high-pressure protein chromatography equipment, including:
  • Äkta Explorer
  • Äkta Purifier
  • Äkta Prime

Protein Crystallization

• Temperature controlled crystallization cabinets
• Sparse matrix crystallization screens covering >300 distinct solution conditions
• Microscopes and integrated CCD imaging system
• Dynamic light scattering instrument
• Crystallization robot

Macromolecular X-ray Diffraction Facilities

• Rapid access to synchrotron radiation
• Rigaku Rotating Anode generator
• Osmic multilayer confocal optics
• Raxis IV++ area detector
• Cryocrystallography capabilities

Computational Resources

• SGI workstations (O2, Octane)
• Dual-processor LINUX workstations
• Dual-processor Mac OS X workstations
• PC’s for lab use

Software Resources and Bioinformatics Tools

• All major software programs for macromolecular crystallographic computing
• Several docking programs
• Several small compound libraries for virtual screening (over 150,000 compounds)