Publications

Only selected examples are given below.  For a complete list of 600 publications from Chang's Laboratory please see:
https://www.mcgill.ca/artcell/files/artcell/changpub.pdf

Selected Examples

Books (free, open access)

(1) Nanobiotherapeutic based Blood Substitutes Edited By TMS Chang, L Bulow, J Jhar, H Sakai, C Yang, 2021 (Book)

(2) Monograph 2007 by Chang Artificial Cells: biotechnology, nanotechnology, regenerative medicine, blood substitutes bioencapsulation and cell/stem cell

(3) Hemoperfusion Review of Hemoperfusion 2017 Opening chapter in 2017 book

(4) "Blood Substitues: principles,methods,products & clinical trials" Chang 1999 Monograph

(5) "Artificial Cells" Monograph by Chang (1972) (Full text of book posted with copyright permission)

Selected Recent Scientific Reviews and Pulications

(1) Reviews on Artificial Cells

2019 Artificial Cells evolves into nanomedicine, biotherapeutics, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, cell/stem cell therapy, nanoparticles, liposomes, bioencapsulation, replicating synthetic cells, cell encapsulation/scaffold, biosorbent/immunosorbent haemoperfusion/plasmapheresis, regenerative medicine, encapsulated microbe, nanobiotechnology, nanotechnology
Review on Artificial Cells: 2019 open access

2005 Therapeutic Applications of polymeric Artificial Cells" from 2005 Nature Review Drug Discovery
Detailed review on "Artificial Cells" from 2005 Nature Review Drug Discovery

Chang (2023) editorial Frontier Medical Technology series on "Innovative Medical Technology based on artificial cells"
https://www.frontiersin.org/articles/10.3389/fmedt.2023.1306419

(2) Review on Hemoperfusion

2017 Opening chapter in 2017 book

(3) Review on Blood Substitutes

(chapter 1 in 2021 book)  (Complete Book available for download below)

(4) Papers on Novel nanobiotherapeutic with enhanced rbc function

2017 Summary
2015 90 mins Hemorrhagic shock
2018 Long term safety and immunology
2015 Extraction of needed enzymes
2016 Temperature stability 4C to 70C
2023 Nanobiotechnological basis of an oxygen carrier with enhanced carbonic anhydrase for CO₂ transport and enhanced catalase and superoxide dismutase for antioxidant function

(5) Synthetic enzymes: neocatalase, neoSOD neoCarbonic anhydrase

2023 Hog & Chang
Preliminary feasibility study on Polyhemoglobin and stable synthetic catalase, superoxide dismutase and carbonic anhydrase: a novel approach for the regeneration of warm ischemic cells/ tissues
Frontier Bioengineering Biotechnology
https://www.frontiersin.org/articles/10.3389/fbioe.2023.1231384

2024 Hoq & Chang Detailed study on effect on ischemic hepatocytes hepatocytes. Scientific Report.
https://www.nature.com/articles/s41598-024-73862-2

2025 (accepted) Myocardiocytes

(6) Nanorobotics

2023 review on Superparamagnetic Artificial Cells PLGA-Fe3O4 Micro/Nanocapsules for Cancer Targeted Delivery. Cancers 2023, 15, 5807 Wang, T.; Chang, T.M.S.(2023)
https://doi.org/10.3390/cancers15245807

2025 accepted Zhao & Chang Superparamagnetic Polyhemoglobin-Tyrosinase Nanocapsules: A Novel Biotherapeutic with Enhanced Tumor Suppression with Control by External Magnetic Field Journal: Frontiers in Bioengineering and Biotechnology, section Nanobiotechnology

(7) Melanoma

2021 Y Wang & Chang Nanobiotherapeutic for melanoma: J Artificial Cell Nanomedicine Biotech

https://doi.org/10.1080/21691401.2021.1918134

(8) COVID-19

2022 Chang "The role of artificial cells in the fight against COVID-19: deliver vaccine, hemoperfusion removes toxic cytokines, nanobiotherapeutics lower free radicals and pCO2 and replenish blood supply" Artificial Cells, Nanomedlicine & Biotechnology). 50:1, 240-251, DOI:
https://doi.org/10.1080/21691401.2022.2126491