Selected Publications

On this page: peer-reviewed journal articles  |  books  |  edited volumes


Peer-Reviewed Journal Articles

  1. M Forest, KJ O’Donnell, G Voisin, H Gaudreau, JL MacIsaac, LM McEwen, P Silveira, M Steiner, MS Kobor, MJ Meaney, CMT Greenwood. Agreement in DNA methylation levels from the Illumina 450K array, across batches, tissues and time. Submitted, 2017.
  2. M Forest, Y Iturria-Medina, JS Goldman, CL Kleinman, A Lovato, K Oros Klein, A Evans, A Ciampi, A Labbe, CMT Greenwood. (2017). Gene Networks Show Associations with Seed Region Connectivity. Human Brain Mapping. Epub ahead of print 2017 Mar 21. Supporting information: File supporting_information1.docx Supplementary Tables: File forest_et_al_2017_table_s1ab.docxFile forest_et_al_2017_table_s2.xlsxFile forest_et_al_2017_table_s3.xlsxFile forest_et_al_2017_table_s8.xlsx
  3. L Lakhal-Chaieb, K Oualkacha, B Richards, C Greenwood. (2016). A rare variant association test in family-based designs and non-normal quantitative traits. Statistics in Medicine, 35(6):905-21. doi: 10.1002/sim.6750.
  4. LE Mokry, S Ross, OS Ahmad, V Forgetta, G Davey-Smith, A Leong, CMT Greenwood, G Thanassoulis, JB Richards. (2015). Vitamin D and risk of Multiple Sclerosis: A Mendelian Randomization Study. PLOS Medicine, 12(8):e1001866. doi: 10.1371/journal.pmed.1001866.
  5. HF Zheng*, V Forgetta*, YH Hsu*, K Estrada*, A Rosello-Diez*, PJ Leo*, CL Dahia*, KH Park-Min*, JH Tobias*, C Kooperberg*, A Kleinman, U Styrkarsdottir, CT Liu, C Uggla, DS Evans, CM Nielson, K Walter, U Pettersson-Kymmer, S McCarthy, J Eriksson, T Kwan, M Jhamai, K Trajanoska, Y Memari, J Min, J Huang, P Danecek, B Wilmot, R Li, WC Chou, LE Mokry, 113 co-authors, RD Jacks
  6. K Oros Klein, S Grinek, S Bernatsky, L Bouchard, A Ciampi, I Colmegna, J-P Fortin, M-F Hivert, M Hudson, MS Kobor, A Labbe, JL MacIsaac, MJ Meaney, AM Morin, KJ O’Donnell, T Pastinen, MH Van Ijzendoorn, G Voisin, CMT Greenwood. (2016). funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types.  Bioinformatics, 32(4):593-5. doi: 10.1093/bioinformatics/btv615.
  7. on†, DW Rowe†, CA Loomis†, DM Evans†, CL Ackert-Bicknell†, AL Joyner†, EL Duncan†, DP Kiel†, F Rivadeneira†, JB Richards† for the GEFOS and UK10K Consortia. * and † denote equal contribution. (2015). Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature, 526(7571):112-7. doi: 10.1038/nature14878.
  8. K Walter*, J Min*, J Huang*, L Crooks*, Y Memari, S McCarthy, JRB Perry, C Xu, M Futema, D Lawson, V Iotchkova, S Schiffels, A Hendricks, P Danecek, R Li, J Floyd, I Barroso, SE Humphries, ME Hurles, E Zeggini, JC Barrett, V Plagnol, JB Richards, C Greenwood, N Timpson, R Durbin, N Soranzo. (2015). The UK10K project: rare variants in health and disease. Nature, 526(7571):82-90. doi: 10.1038/nature14962.
  9. JP Fortin, A Labbe, M Lemire, BW Zanke, TJ Hudson, EJ Fertig, CMT Greenwood, KD Hansen. (2014). Functional normalization of 450K methylation array data improves replication in large cancer studies.  Genome Biology, 15(11):503. doi: 10.1186/s13059-014-0503-2. Note: JP Fortin, a former student, was awarded the John Van Ryzin Award for being the best paper submitted in 2014 to the International Biometric Society Eastern North American Region’s (ENAR) Distinguished Student Paper Award Competition.
  10. KM Burkett, B McNeney, J Graham, CMT Greenwood. (2014). Using gene genealogies to detect rare variants associated with complex traits. Human Heredity, 78:117-130.
  11. C Xu, A Ciampi, CMT Greenwood, the UK10K Consortium. (2014) Exploring the potential benefits of stratified false discovery rates for region based testing of association with rare genetic variation. Frontiers in Genetics: Statistical Genetics and Methodology, (5):11. doi: 10.3389/fgene.2014.00011.
  12. C Xu, I Tachmazidou, UK10K Consortium, A Ciampi, E Zeggini, CMT Greenwood. (2014). Estimating genome-wide significance for whole genome sequencing studies. Genetic Epidemiology, 38(4):281-90. doi: 10.1002/gepi.21797.
  13. K Burkett, CMT Greenwood, B McNeney, J Graham. (2013). Gene genealogies for genetic association mapping, with application to Crohn’s disease. Frontiers in Genetics: Statistical Genetics and Methodology, 4:260. doi: 10:3389/fgene.2013.00260.
  14. K Burkett, C Greenwood. (2013).  A sequence of methodological changes due to sequencing.  Current Opinion in Allergy and Clinical Immunology.  13(5):470-7. doi: 10.1097/ACI.0b013e3283648f68.
  15. K Oualkacha, Z Dastani, R Li, PE Cingolani, TD Spector, CJ Hammond, JB Richards, A Ciampi, CMT Greenwood. (2013). Adjusted Sequence Kernel Association Test for Rare Variants Controlling for Cryptic and Family Relatedness. Genet. Epidemiol. 37: 366–376. doi: 10.1002/gepi.21725.
  16. K Klein Oros, SL Arcand, JA Squire, A-M Mes-Masson, PN Tonin, CMT Greenwood. (2013).  Analysis of genomic abnormalities in tumours: a review of available methods for Illumina two-color SNP genotyping and evaluation of performance.  Cancer Genetics, 206(4):103-15.  doi: 10.1016/j.cancergen.2013.03.001.
  17. P Hu, X Wang, JJ Haitsma, S Furmli, H Masoom, M Liu, AS Slutsky, J Beyene, CMT Greenwood, CD Santos. (2012). Microarray meta-analysis identifies acute lung injury biomarkers in donor lungs that predict development of primary graft failure in recipients. PLoS ONE 7 (10): e45506. doi: 10.1371/journal.pone.0045506.
  18. C Xu, M Ladouceur, JB Richards, A Ciampi, CMT Greenwood. (2012). Multiple regression methods show great potential for rare variant association tests. PLoS ONE 7(8): e41694.
  19. JS Hamid, CMT Greenwood, Joseph Beyene. (2012). Weighted kernel Fisher discriminant analysis for Integrating Heterogeneous Data. Computational Statistics and Data Analysis, 56: 2031-2040.
  20. M Ladouceur, Z Dastani, YS Aulchenko, MG Ehm, CMT Greenwood, JB Richards. (2011). The empirical power of rare variant association methods: Results from Sanger sequencing in 1,998 individuals. PLoS Genet, 8(2): e1002496. doi:10.1371/journal.pgen.1002496
  21. CMT Greenwood, AD Paterson, L Linton, IL Andrulis, C Apicella, A Dimitromanolakis, V Kriukov, LJ Martin, A Salleh, E Samiltchuk, RV Parekh, MC Southey, EM John, JL Hopper, NF Boyd, JM Rommens. (2011). A genome-wide linkage study of mammographic density, a risk factor for breast cancer. Journal of Breast Cancer Research, 13(6):R132.
  22. AH Birch,  SL Arcand, KK Oros, K Rahimi, AK Watters, D Provencher, CM Greenwood, AM Mes-Masson, PN Tonin (2011). Chromosome 3 anomalies investigated by genome wide SNP analysis of benign, low malignant potential and low grade ovarian serous tumours. PLoS One. 6(12): e28250. doi:10.1371/journal.pone.0028250.
  23. J Husted, A Bassett, C Greenwood. (2010). Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia. Schizophrenia Research, 116 : 289-290.
  24. SJ Hawken, CMT Greenwood, TJ Hudson, R Kustra, J McLaughlin, Q Yang, BW Zanke, J Little. (2010).  The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.  Human Genetics, 128(1):89-101.
  25. JS Hamid, P Hu, NM Roslin, V Ling, CM Greenwood, J Beyene. (2009). Data integration in genetics and genomics: methods and challenges. Hum Genomics Proteomics. Volume 2009, Article ID 869093, 13 pages. doi:10.4061/2009/869093.
  26. B Shahbaba, AJ Gentles, J Beyene, SK Plevritis, CMT Greenwood. (2009). A Bayesian nonparametric method for model evaluation. Journal of Nonparametric Statistics, 21(2): 379-396.
  27. JA Husted, S Lim, EW Chow, C Greenwood, AS Bassett (2009). Heritability of neurocognitive traits in familial schizophrenia. American Journal of Medical Genetics B: Neuropsychiatric Genetics, 150B(6):845-53.
  28. R Kustra, X Shi, DJ Murdoch, CMT Greenwood, J Rangrej. (2008). Efficient p-value estimation in massively parallel testing problems.  Biostatistics, 9(4):601-12.
  29. S Sun, CMT Greenwood, RM Neal. (2007). Haplotype inference using a Bayesian Hidden Markov model. Genetic Epidemiology, 31(8):937-48.
  30. BW Zanke, CMT Greenwood, J Rangrej, R Kustra, A Tenesa, SM Farrington, J Prendergast, S Olschwang, T Chiang, E Crowdy, V Ferretti, P Laflamme, S Sundararajan, S Roumy, J-F Olivier, F Robidoux, R Sladek, A Montpetit, P Campbell, S Bezieau, AM O’Shea, G Zogopoulos, M Cotterchio, P Newcomb, J McLaughlin, B Younghusband, R Green, J Green,  MEM Porteous, H Campbell, H Blanche, M Sahbatour, E Tubacher, C Bonaiti-Pellié, B Buecher, E Riboli, S Kury, S Chanock, J Potter, G Thomas, S Gallinger, TJ Hudson, M Dunlop. (2007). Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nature Genetics, 39(8):989-94.
  31. CMT Greenwood, J Rangrej, L Sun. (2007). Optimal selection of markers for validation or replication from genome-wide association studies. Genetic Epidemiology, 31:396-407.
  32. CMT Greenwood, TM Fujiwara, LJ Boothroyd, MA Miller, D Frappier, EA Fanning, E Schurr, K Morgan. (2000).  Linkage of tuberculosis to chromosome 2q35 loci, including NRAMP1, in a large aboriginal Canadian family. American Journal of Human Genetics, 67:405-416.
  33. CMT Greenwood, SB Bull. (1999). Down-weighting of multiple affected sib pairs leads to biased likelihood ratio tests under no linkage.  Letter, American Journal of Human Genetics, 64: 1248-1252.
  34. CMT Greenwood, SB Bull. (1999).  Analysis of affected sib pair models with covariates, with and without constraints. American Journal of Human Genetics, 64: 871-885.


  Book Chapters

  1. CMT Greenwood, C Xu, A Ciampi. (2015). Significance thresholds for rare variant signals. 169-183. Assessing rare variation in complex traits: design and analysis of genetic studies.  Editors: Andrew Morris, Eleftheria Zeggini.  Springer, New York. DOI: 10.1007/978-1-4939-2824-8
  2. SB Bull, J Graham, CM Greenwood. (2014). Statistical Genetic Modeling and Analysis of Complex Traits in Human Populations. 125-146. Statistics in Action: A Canadian Outlook. Editor: Jerry Lawless. Statistical Society of Canada.
  3. W Xu, SB Bull, L Mirea, CM Greenwood. (2013). Model-free linkage analysis of a binary trait.  Methods in Molecular Biology: 850: 317-345. Statistical Human Genetics. Editors: Robert C. Elston, Jaya Satagopan, Shuying Sun. Humana Press.


  Edited Volumes

  1. Epigenetics and Complex Traits (2013).  Editors:  AK Naumova, CMT Greenwood.  Springer, New York.


To see a full list of publications, please contact Celia Greenwood.