McGill.CA / Étude de cohorte HITCH

Reports of Study Findings

Oral cancer-causing HPV transmission

Nov. 12, 2014 - McGill study helps identify those most at risk for oral human papillomavirus (HPV). 

Oral human papillomavirus (HPV) infections were more common among men who had female partners with oral and/or genital HPV infection, suggesting that the transmission of HPV occurs via oral-oral and oral-genital routes, according to a McGill University study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.  Read more

56 per cent of young adults in a new sexual relationship infected with HPV

Jan. 14, 2010 - Researchers of the HITCH Cohort Study found more than half (56 per cent) of young adults in a new sexual relationship were infected with human papillomavirus (HPV). Of those, nearly half (44 per cent) were infected with an HPV type that causes cancer.

The aim of HITCH is to determine the prevalence of HPV infections among recently formed couples. This is the first large-scale study of HPV infection among couples early in their sexual relationships when transmission is most likely.

The results, published in the January 2010 issues of Epidemiology and Sexually Transmitted Diseases, also indicate there is a high probability of HPV transmission between partners. When one partner had HPV, the researchers observed that in 42 per cent of couples, the other partner also had the infection. Moreover, the researchers found that the presence of HPV in one partner was the strongest predictor of finding the same HPV type in the other partner. If one partner was infected with HPV, the other partner’s chance of also being infected with the same HPV type increased over 50 times.

These results build on our knowledge that HPV infection is very common among young adults, and underline the importance of prevention programs for HPV-associated diseases such as cervical cancer screening and HPV vaccination. Our results also suggest that HPV is an easy virus to get and to transmit. Our estimates of the HPV transmission probability will be of use to other researchers who use modeling to project the public health and economic impact of HPV vaccination strategies.

Our study is the first to investigate HPV transmission in a large number of new couples among young adults. The results suggest that many HPV transmissions occur at the start of new relationships, which reinforces the need for prevention.

 

Publications:

1.

Vaccination of Young Women Decreases Human Papillomavirus Transmission in Heterosexual Couples: Findings from the HITCH Cohort Study.

Wissing MD, Burchell AN, El-Zein M, Tellier PP, Coutlée F, Franco EL.

Cancer Epidemiol Biomarkers Prev. 2019 Nov;28(11):1825-1834. doi: 10.1158/1055-9965.EPI-19-0618. Epub 2019 Sep 5.

PMID: 31488413 Free PMC article.

2.

Human Papillomavirus Viral Load and Transmission in Young, Recently Formed Heterosexual Couples.

Wissing MD, Louvanto K, Comète E, Burchell AN, El-Zein M, Rodrigues A, Tellier PP, Coutlée F, Franco EL.

J Infect Dis. 2019 Aug 30;220(7):1152-1161. doi: 10.1093/infdis/jiz238.

PMID: 31063542 Free PMC article.

3.

Hand-to-genital and genital-to-genital transmission of human papillomaviruses between male and female sexual partners (HITCH): a prospective cohort study.

Malagón T, Louvanto K, Wissing M, Burchell AN, Tellier PP, El-Zein M, Coutlée F, Franco EL.

Lancet Infect Dis. 2019 Mar;19(3):317-326. doi: 10.1016/S1473-3099(18)30655-8. Epub 2019 Feb 10.

PMID: 30745276 Free PMC article.

4.

Human Papillomavirus Infection and Transmission Among Couples Through Heterosexual Activity (HITCH) Cohort Study: Protocol Describing Design, Methods, and Research Goals.

El-Zein M, Coutlée F, Tellier PP, Roger M, Franco EL, Burchell AN; HITCH Study Group.

JMIR Res Protoc. 2019 Jan 16;8(1):e11284. doi: 10.2196/11284.

PMID: 30650383 Free PMC article.

5.

Y Chromosome DNA in Women's Vaginal Samples as a Biomarker of Recent Vaginal Sex and Condom Use With Male Partners in the HPV Infection and Transmission Among Couples Through Heterosexual Activity Cohort Study.

Malagón T, Burchell A, El-Zein M, Guénoun J, Tellier PP, Coutlée F, Franco EL; HITCH study group.

Sex Transm Dis. 2018 Jan;45(1):28-34. doi: 10.1097/OLQ.0000000000000688.

PMID: 28876295 Free PMC article. Clinical Trial.

6.

Estimating HPV DNA Deposition Between Sexual Partners Using HPV Concordance, Y Chromosome DNA Detection, and Self-reported Sexual Behaviors.

Malagón T, Burchell AN, El-Zein M, Guénoun J, Tellier PP, Coutlée F, Franco EL; HITCH Study Group.

J Infect Dis. 2017 Dec 5;216(10):1210-1218. doi: 10.1093/infdis/jix477.

PMID: 28968731 Free PMC article.

7.

Assortativity and Mixing by Sexual Behaviors and Sociodemographic Characteristics in Young Adult Heterosexual Dating Partnerships.

Malagón T, Burchell A, El-Zein M, Tellier PP, Coutlée F, Franco EL; HITCH study group.

Sex Transm Dis. 2017 Jun;44(6):329-337. doi: 10.1097/OLQ.0000000000000612.

PMID: 28499281 Free PMC article.

8.

Epidemiologic Evaluation of Human Papillomavirus Type Competition and the Potential for Type Replacement Post-Vaccination.

Tota JE, Jiang M, Ramanakumar AV, Walter SD, Kaufman JS, Coutlée F, Richardson H, Burchell AN, Koushik A, Mayrand MH, Villa LL, Franco EL.

PLoS One. 2016 Dec 22;11(12):e0166329. doi: 10.1371/journal.pone.0166329. eCollection 2016.

PMID: 28005904 Free PMC article.

9.

Cervical Infection With Vaccine-Associated Human Papillomavirus (HPV) Genotypes as a Predictor of Acquisition and Clearance of Other HPV Infections.

Tota JE, Ramanakumar AV, Villa LL, Richardson H, Burchell AN, Coutlée F, Franco EL.

J Infect Dis. 2016 Sep 1;214(5):676-84. doi: 10.1093/infdis/jiw215. Epub 2016 Jun 2.

PMID: 27256157 Free PMC article.

10.

Sexual transmission of oral human papillomavirus infection among men.

Dahlstrom KR, Burchell AN, Ramanakumar AV, Rodrigues A, Tellier PP, Hanley J, Coutlée F, Franco EL.

Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2959-64. doi: 10.1158/1055-9965.EPI-14-0386. Epub 2014 Nov 12.

PMID: 25392180

11.

Evaluation of human papillomavirus type replacement postvaccination must account for diagnostic artifacts: masking of HPV52 by HPV16 in anogenital specimens.

Tota JE, Ramanakumar AV, Villa LL, Richardson H, Burchell AN, Koushik A, Mayrand MH, Coutlée F, Franco EL.

Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):286-90. doi: 10.1158/1055-9965.EPI-14-0566. Epub 2014 Oct 2.

PMID: 25277793 Free PMC article.

12.

Determinants of prevalent human papillomavirus in recently formed heterosexual partnerships: a dyadic-level analysis.

Burchell AN, Rodrigues A, Moravan V, Tellier PP, Hanley J, Coutlée F, Franco EL.

J Infect Dis. 2014 Sep 15;210(6):846-52. doi: 10.1093/infdis/jiu200. Epub 2014 Mar 27.

PMID: 24683197 Free PMC article.

13.

Genital transmission of human papillomavirus in recently formed heterosexual couples.

Burchell AN, Coutlée F, Tellier PP, Hanley J, Franco EL.

J Infect Dis. 2011 Dec 1;204(11):1723-9. doi: 10.1093/infdis/jir644. Epub 2011 Oct 7.

PMID: 21984739 Free PMC article.

14.

Generic microtiter plate assay for triaging clinical specimens prior to genotyping of human papillomavirus DNA via consensus PCR.

Legault V, Burchell A, Goggin P, Nicolau B, Brassard P, Guenoun J, Forest P, Mayrand MH, Franco EL, Coutlée F.

J Clin Microbiol. 2011 Nov;49(11):3977-9. doi: 10.1128/JCM.05646-11. Epub 2011 Sep 21.

PMID: 21940471 Free PMC article.

15.

Human papillomavirus infections among couples in new sexual relationships.

Burchell AN, Tellier PP, Hanley J, Coutlée F, Franco EL.

Epidemiology. 2010 Jan;21(1):31-7. doi: 10.1097/EDE.0b013e3181c1e70b.

PMID: 19907332

16.

Influence of partner's infection status on prevalent human papillomavirus among persons with a new sex partner.

Burchell AN, Tellier PP, Hanley J, Coutlée F, Franco EL.

Sex Transm Dis. 2010 Jan;37(1):34-40. doi: 10.1097/OLQ.0b013e3181b35693.

PMID: 19704391

 

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HITCH Study Results
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