Duggavathi, Raj

Duggavathi's research focuses on mechanisms of regulation of female fertility with emphasis on ovarian function. His team pursues their research interests in two modules.

In module 1, targeting animal agriculture, they investigate metabolic regulation of ovarian function in cattle. In the last ten years they have discovered that metabolic indicators differ significantly between lactating dairy cows and their non-lactating counterparts. Their current studies investigate, using randomized controlled experiments as well as big data observational studies, the relationship between ovarian activity and metabolic stress including ketosis.

In module 2, focusing on fundamental mechanisms applicable to both farm animals and women, they use signaling pathway- and gene-edited mouse models to investigate mechanisms of follicular development, ovulation and fertility. In the last ten years they have discovered novel transcription factors involved in the ERK1/2 intracellular signaling pathways as well as important molecules involved in ovulation. They have also discovered that pituitary gonadotropins modulate histone methylation to regulate gene expression underpinning follicular development.

Their current studies focus on the role of histone modifications and transcription factors such as Egr1 in granulosa cell gene expression. Their research will continue to advance the understanding of molecular mechanisms underpinning normal ovarian functions, including ovulation and steroid hormone production, leading to normal female fertility.