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Tim Geary - Publications

Tritten L, Burkman E, Moorhead A, et al. (2014) Detection of circulating parasite-derived microRNAs in filarial infections. PLoS Negl Trop Dis 8: e2971.

Sassi AJ, Geary JF, Leroux LP, et al. (2014) Identification of Dirofilaria immitis proteins recognized by antibodies from infected dogs. J Parasitol 100: 364-7.

Longo M, Zanoncelli S, Messina M, et al. (2014) In vivo preliminary investigations of the effects of the benzimidazole anthelmintic drug flubendazole on rat embryos and fetuses. Reprod Toxicol 49C: 33-42.

Chehayeb JF, Robertson AP, Martin RJ and Geary TG (2014) Proteomic analysis of adult Ascaris suum fluid compartments and secretory products. PLoS Negl Trop Dis 8: e2939.

Ceballos L, Mackenzie C, Geary T, Alvarez L and Lanusse C (2014) Exploring the potential of flubendazole in filariasis control: evaluation of the systemic exposure for different pharmaceutical preparations. PLoS Negl Trop Dis 8: e2838.

Larsen MJ, Lancheros ER, Williams T, Lowery DE, Geary TG and Kubiak TM (2013) Functional expression and characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in mammalian cells and yeast. Int J Parasitol Drugs Drug Resist 3: 1-7.

Dufour V, Beech RN, Wever C, Dent JA and Geary TG (2013) Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni. PLoS Pathog 9: e1003586.

Geary TG and Moreno Y (2012) Macrocyclic lactone anthelmintics: spectrum of activity and mechanism of action. Curr Pharm Biotechnol 13: 866-72.

Geary TG, Chibale K, Abegaz B, Andrae-Marobela K and Ubalijoro E (2012) A new approach for anthelmintic discovery for humans. Trends Parasitol 28: 176-81.

Geary TG (2012) Are new anthelmintics needed to eliminate human helminthiases? Curr Opin Infect Dis 25: 709-17.

Ruiz-Lancheros E, Viau C, Walter TN, Francis A and Geary TG (2011) Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans. Int J Parasitol 41: 455-61.

Nwaka S, Besson D, Ramirez B, et al. (2011) Integrated dataset of screening hits against multiple neglected disease pathogens. PLoS Negl Trop Dis 5: e1412.

Moreno Y, Gros PP, Tam M, et al. (2011) Proteomic analysis of excretory-secretory products of Heligmosomoides polygyrus assessed with next-generation sequencing transcriptomic information. PLoS Negl Trop Dis 5: e1370.

Mackenzie CD and Geary TG (2011) Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs. Expert Rev Anti Infect Ther 9: 497-501.

Geary TG and Mackenzie CD (2011) Progress and challenges in the discovery of macrofilaricidal drugs. Expert Rev Anti Infect Ther 9: 681-95.

Geary TG, Bourguinat C and Prichard RK (2011) Evidence for macrocyclic lactone anthelmintic resistance in Dirofilaria immitis. Top Companion Anim Med 26: 186-92.

Bourguinat C, Keller K, Prichard RK and Geary TG (2011) Genetic polymorphism in Dirofilaria immitis. Vet Parasitol 176: 368-73.

Bourguinat C, Keller K, Blagburn B, Schenker R, Geary TG and Prichard RK (2011) Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype. Vet Parasitol 176: 374-81.

Bourguinat C, Keller K, Bhan A, Peregrine A, Geary T and Prichard R (2011) Macrocyclic lactone resistance in Dirofilaria immitis. Vet Parasitol 181: 388-92.

Moreno Y, Nabhan JF, Solomon J, Mackenzie CD and Geary TG (2010) Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi. Proc Natl Acad Sci U S A 107: 20120-5.

Mackenzie CD, Huntington MK, Wanji S, Lovato RV, Eversole RR and Geary TG (2010) The association of adult Onchocerca volvulus with lymphatic vessels. J Parasitol 96: 219-21.

Geary TG, Woo K, McCarthy JS, et al. (2010) Unresolved issues in anthelmintic pharmacology for helminthiases of humans. Int J Parasitol 40: 1-13.

Geary TG and Maule AG (2010) Neuropeptide systems as targets for parasite and pest control. Preface. Adv Exp Med Biol 692: v-vi.

Geary TG (2010) Nonpeptide ligands for peptidergic G protein-coupled receptors. Adv Exp Med Biol 692: 10-26.

Bourguinat C, Kamgno J, Boussinesq M, Mackenzie CD, Prichard RK and Geary TG (2010) Analysis of the mdr-1 gene in patients co-infected with Onchocerca volvulus and Loa loa who experienced a post-ivermectin serious adverse event. Am J Trop Med Hyg 83: 28-32.

Schwab AE, Geary TG, Baillargeon P, Schwab AJ and Fecteau G (2009) Association of BoLA DRB3 and DQA1 alleles with susceptibility to Neospora caninum and reproductive outcome in Quebec Holstein cattle. Vet Parasitol 165: 136-40.

Prichard RK and Geary TG (2008) Drug discovery: fresh hope to can the worms. Nature 452: 157-8.

Moreno Y and Geary TG (2008) Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory products. PLoS Negl Trop Dis 2: e326.

Kubiak TM, Larsen MJ, Bowman JW, Geary TG and Lowery DE (2008) FMRFamide-like peptides encoded on the flp-18 precursor gene activate two isoforms of the orphan Caenorhabditis elegans G-protein-coupled receptor Y58G8A.4 heterologously expressed in mammalian cells. Biopolymers 90: 339-48.

Prichard RK, von Samson-Himmelstjerna G, Blackhall WJ and Geary TG (2007) Foreword: towards markers for anthelmintic resistance in helminths of importance in animal and human health. Parasitology 134: 1073-6.

Omar HH, Humphries JE, Larsen MJ, et al. (2007) Identification of a platyhelminth neuropeptide receptor. Int J Parasitol 37: 725-33.

McVeigh P, Leech S, Marks NJ, Geary TG and Maule AG (2006) Gene expression and pharmacology of nematode NLP-12 neuropeptides. Int J Parasitol 36: 633-40.

McVeigh P, Geary TG, Marks NJ and Maule AG (2006) The FLP-side of nematodes. Trends Parasitol 22: 385-96.

Geary TG (2005) Ivermectin 20 years on: maturation of a wonder drug. Trends Parasitol 21: 530-2.