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Chemical Society Seminar: Dr. Amani Hariri - Advancing DNA Nanotechnology Using Single Molecule Fluorescence Methodologies

23 Jan 2018 13:00
14:30

DNA is a reliable and programmable nanofabrication building block. Taking advantage of its nanoscale features, I used it extensively to generate complex reconfigurable assemblies with many recent potential applications. My PhD research can be divided into four main parts: (i) synthesis optimization (Hariri et. al. 2015), (ii) structural characterization (Hariri et. al. 2017), (iii) monitoring dynamic structures (Rahbani et al. 2015), and (iv) studying structural dynamics (Platnich et. al....

Chemical Society Seminar: Dr. Robert Britton - Natural and not so Natural Products: From Medicinal Chemistry to Bed Bug Communication

30 Jan 2018 13:00
14:30

Our research encompasses several aspects of natural product chemistry and drug discovery. Specifically, we are engaged in the structural identification and large scale synthesis of insect pheromones as well as the development of synthetic methods and strategies to access stereochemically rich heterocyclic natural products as leads for drug discovery. Central to our research philosophy is an emphasis on step economy and flexibility....

Chemical Society Seminar: Dr. Molly Shoichet - Turning Lemons into Lemonade: Controlling Protein Release by Affinity

6 Feb 2018 13:00
14:30

Controlling protein release has typically been achieved by using strategies similar to those used for controlled drug delivery; however, this method of encapsulation in biodegradable polymeric nanospheres is inherently limited in the amount and bioavailability of the released proteins.  Typically, less than 0.1% by mass of protein is encapsulated and the exposure to shear and organic solvents impacts protein activity.  While working in this area, we discovered encapsulation-free pro...

Chemical Society Seminar: Dr. Andrei Yudin - Development of bioactive molecules using the tools of chemical synthesis

13 Feb 2018 13:00
14:30

Production of molecules with desired functional attributes is the enduring objective of chemical synthesis. As structural complexity of therapeutic agents increases, so is the number of interrelated parameters that need to be controlled. Bioactive macrocycles offer a good example underscoring this notion. Their relatively large polar surface area increases the chance to interrogate extended protein binding sites, but also creates an impediment to achieving favorable drug properties....

A Talk by Dr. Aaron Beeler

20 Feb 2018 13:00
14:30

Chemical Society Seminar: Dr. Ryan Shenvi - How to peel a coin: separation of structural and synthetic complexity

27 Feb 2018 13:00
14:30

Structural complexity and synthetic complexity are closely related but non-identical molecular attributes. The more structurally complex a molecule, the more complex its synthesis. As a result, hard-to-synthesize natural products have become less popular as lead scaffolds in drug development. But can structural complexity be separated from synthetic complexity?

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Chemical Society Seminar: Dr. L.C.Campeau - Rumors of Chemistry’s Demise Have Been Greatly Exaggerated: Synthetic Chemistry is Not Dead Is Drug Discovery & Development

13 Mar 2018 13:00
14:30

How important is synthetic chemistry innovation in drug discovery? Can world class synthetic chemistry expertise impact and quality of molecules chosen to develop and become drugs? This presentation will focus on Merck’s strategy to make investments in world-class chemistry capabilities early in the discovery of novel therapeutics....

TBA

20 Mar 2018 13:00
14:30

CCVC Seminar -Dr. Gary Molander - "Single Electron Processes to Enable Organic Synthesis"

27 Mar 2018 13:00
14:30

In traditional cross-coupling reactions, a three-step catalytic cycle mechanistically based on 2-electron processes is employed: oxidative addition of a halide at Pdº or Niº, transmetalation of an organometallic nucleophile with the oxidative addition intermediate, and reductive elimination, which releases the coupled product and regenerates the Pd0 or Niº catalyst....

A Talk by Dr. Eugenia Kumachev

3 Apr 2018 13:00
14:30

A Talk by Dr. Jillian Buriak

10 Apr 2018 13:00
14:30

Chemical Society Seminar: Dr. Xiaoyang Zhu - Crystal-Liquid Duality in Lead Halide Perovskites

17 Apr 2018 13:00
14:30

Lead halide perovskites have been demonstrated as high performance materials in solar cells and light-emitting devices. These materials are characterized by coherent band transport expected from crystalline semiconductors, but dielectric responses and phonon dynamics typical of liquids. This “crystal-liquid” duality implies that lead halide perovskites belong to phonon glass electron crystals, a class of materials believed to make the most efficient thermoelectrics....

CCVC Seminar- Dr. Guy Bertrand - "Stable carbenes and related species as powerful tools in organic, organometallic, and inorganic chemistry."

24 Apr 2018 13:00
14:30

It will be shown that the peculiar electronic and steric properties of cyclic (alkyl)(amino)carbenes (CAACs) (1,2) and other stable singlet carbenes allow for the stabilization of unusual diamagnetic and paramagnetic main group element species. As examples, we will describe the preparation of room temperature stable boron, antimony-, and even carbon-centered neutral and cationic radicals....