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About the Clinical Exercise & Respiratory Physiology Laboratory (CERPL)

Research in the CERPL focuses on identifying the mechanisms of activity-related breathing discomfort (dyspnea) and exercise intolerance in health, variants of health (e.g., elderly, obesity) and in patients with chronic cardiorespiratory disease (e.g., COPD, heart failure).

We employ an integrative physiological approach and a comprehensive suite of human physiological measurement techniques to better understand how physiological and pathophysiological abnormalities of neural respiratory drive, dynamic respiratory mechanical/muscular function, cardiometabolic and peripheral locomotor muscle function, ventilatory control, acid-base balance and their complex interaction(s) contribute to the origin of dyspnea and exercise intolerance in these populations.  

This information, in turn, helps to develop effective treatments aimed at improving exertional symptoms, functional capacity and health-related quality-of-life in various patient populations.