Professor, Departments of Oncology and Medicine, McGill University
Director, Clinical Research Unit, Jewish General Hospital
Lady Davis Institute for Medical Research
Sir Mortimer B. Davis-Jewish General Hospital
3755 Côte Ste-Catherine Road
Montreal, Quebec H3T 1E2
Tel.: 514-340-8222 ext. 4365
wmiller [at] ldi.jgh.mcgill.ca (Email)
Expertise: Molecular Biology of Retinoids and Tumor Differentiation
Summary of Research Activities
The laboratory uses the tools of molecular biology to study the mechanisms of action of retinoids (active derivatives of vitamin A) and their nuclear receptors, with the goal of developing new treatments for cancer. Current projects focus on how retinoid activation of transcription factors and interaction with signaling pathways can induce differentiation, growth inhibition, and apoptosis of human cancer cells. Acute promyelocytic leukemia (APL) has provided a model for our efforts to understand retinoid action at the molecular level and to broaden their indication for additional malignancies. We are evaluating additional novel transcriptional therapies, including inhibition of histone deacetylase and methylation, to overcome resistance to retinoids, in a variety of malignant cells with intrinsic or induced resistance to retinoids. We are also investigating retinoids in breast cancer cells, specifically interactions between the estrogen receptor, intracellular signaling pathways, and the transcriptional and growth inhibitory response to retinoids. Finally, our research has led to the study of mechanisms of induction of apoptosis by arsenic trioxide, a highly effective salvage treatment for APL patients, and other novel agents in leukemia and other malignancies.
Cohen V, Agulnik JS, Jarry J, Batist G, Small D, Kreisman H, Adriana Tejada N, Miller WH Jr, Chong G. Evaluation of denaturing high-performance liquid chromatography as a rapid detection method for identification of epidermal growth factor receptor mutations in nonsmall-cell lung cancer. Cancer. 2006 Dec 15;107(12):2858-65
Assouline S, Miller WH. High-dose vitamin C therapy: renewed hope or false promise? CMAJ. 2006 Mar 28;174(7):956-7.