Sylvie Mader

Professor, Université de Montréal, Department of Biochemistry
Adjunct Professor, McGill University, Department of Medicine
Holder of the CIBC research chair on the causes of breast cancer

Département de biochimie
Faculté de Médecine
Pavillon Roger-Gaudry - B-336-1
Université de Montréal
C.P. 6128, Succ. Centre-ville
Montreal, Quebec H3C 3J7

Tel.: 514-343-7166
Fax: 514-343-6843
sylvie.mader [at] (Email)
Dr. Mader's Website

Expertise: Bioinformatics, genomics and proteomics; Control of gene expression; Cell signaling; Developmental biology; Senescence; Cancer

Recent Publications
Nguyen D, Bail M, Pesant G, Dupont VN, Rouault E, Deschenes J, Rocha W, Melancon G, Steinberg SV, Mader S. Rational design of an estrogen receptor mutant with altered DNA-binding specificity. Nucleic Acids Res. 2007 May 3; [Epub ahead of print]

Deschenes J, Bourdeau V, White JH, Mader S. Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 KB of upstream flanking sequences. J Biol Chem. 2007 Apr 26; [Epub ahead of print]

Lupien M, Jeyakumar M, Hebert E, Hilmi K, Cotnoir-White D, Loch C, Auger A, Dayan G, Pinard GA, Wurtz JM, Moras D, Katzenellenbogen J, Mader S. Raloxifene and ICI182,780 increase estrogen receptor-alpha association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12. Mol Endocrinol. 2007 Apr;21(4):797-816. Epub 2007 Feb 13.

Laperriere D, Wang TT, White JH, Mader S. Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolution. BMC Genomics. 2007 Jan 19;8:23.

Brodeur H, Chagnon S, Parisotto M, Mader S, Bhat PV. Kinetic properties of chimeric class I aldehyde dehydrogenases for retinal isomers. Biochem Cell Biol. 2006 Oct; 84(5):799-804.

Parisotto M, Brodeur H, Bhat PV, Mader S. Retinoid metabolism and cancer. Med Sci (Paris). 2006 Dec;22(12):1101-1106.

Tavera-Mendoza LE, Mader S, White JH. Genome-wide approaches for identification of nuclear receptor target genes. Nucl Recept Signal. 2006;4:e018. Epub 2006 Jul 7.

Dayan G, Lupien M, Auger A, Anghel SI, Rocha W, Croisetiere S, Katzenellenbogen JA, Mader S. Tamoxifen and raloxifene differ in their functional interactions with aspartate 351 of estrogen receptor alpha. Mol Pharmacol. 2006 Aug;70(2):579-88. Epub 2006 May 5.

Tavera-Mendoza L, Wang TT, Lallemant B, Zhang R, Nagai Y, Bourdeau V, Ramirez-Calderon M, Desbarats J, Mader S, White JH. Convergence of vitamin D and retinoic acid signalling at a common hormone response element. EMBO Rep. 2006 Feb;7(2):180-5.

Rocha W, Sanchez R, Deschenes J, Auger A, Hebert E, White JH, Mader S. Opposite effects of histone deacetylase inhibitors on glucocorticoid and estrogen signaling in human endometrial Ishikawa cells. Mol Pharmacol. 2005 Dec;68(6):1852-62. Epub 2005 Sep 26.

Mann KK, Davison K, Colombo M, Colosimo AL, Diaz Z, Padovani AM, Guo Q, Scrivens PJ, Gao W, Mader S, Miller WH Jr. Antimony trioxide-induced apoptosis is dependent on SEK1/JNK signaling. Toxicol Lett. 2006 Jan 5;160(2):158-70. Epub 2005 Aug 19.