Microengineered Human Physiological Systems: Inspired by Nature
Pouria Fattahi
Postdoctoral Fellow
Department of Bioengineering, University of Pennsylvania
Human organs embody complex living systems wherein specialized cells and tissues harmoniously unite in diverse proportions and arrangements. These configurations enable the seamless execution of integrated functions crucial for the survival of the entire organism. A predominant challenge in the field has been the absence of model systems capable of replicating tissue-level architecture. An ideal model must faithfully mimic the hierarchical structures inherent to our organs, wherein diverse cell types self-organize into various tissues, each endowed with specialized functions. This presentation will explore interdisciplinary research initiatives focused on developing microengineered biomimetic models designed to accurately replicate the intricate structures, dynamic microenvironments, and physiological functions found in human organs. Specifically, I will discuss two key projects:
i) Investigating a bioinspired microsystem designed to emulate both the structural and functional complexities of the epithelium lining the respiratory tract interface within the human lung.
ii) Developing a microengineered biomimetic model of the placental barrier to investigate environmental exposures during pregnancy.
Bio.
Pouria Fattahi, a native of Iran, currently serves as a Postdoctoral Fellow at the Department of Bioengineering, University of Pennsylvania. Pronounced as 'P - oo r iah,' Pouria commenced his academic journey in Chemical Engineering at the Sharif University of Technology (SUT) in Iran, renowned for its excellence in STEM disciplines. His academic pursuits led him to Pennsylvania State University, where he earned both his MSc. and Ph.D. in bioengineering under the mentorship of Drs. Justin L Brown and Peter J. Butler. Following this, Pouria continued his research journey as a postdoctoral fellow in Dr. Alexander Revzin's laboratory at Mayo Clinic Rochester, Minnesota. During this period, he engaged with various tools and technologies, including stem cell microencapsulation and valve-enabled microfluidic co-culture systems, with a focus on guiding stem cell differentiation towards beta cells and hepatocytes. Amid the challenges posed by the pandemic, Pouria joined the laboratory of Dr. Dan Huh, the inventor, and pioneer of the original lung-on-a-chip technology, to construct highly advanced in vitro technologies for engineering realistic living human lung and placenta tissues and subjecting them to physiologically relevant exposure conditions for toxicants. Pouria has garnered recognition for his contributions, receiving prestigious awards such as the Center of Excellence in Environmental Toxicology (CEET) Mentored Scientist Transition Award (MSTA) and the Amnion Foundation Seed Grant. His diverse academic and research experiences underscore his commitment to advancing the frontiers of bioengineering and environmental toxicology.
