Biotechnology : Principles and methodologies of structure-based molecular design, optimization, and development of therapeutic monoclonal antibodies. Role in therapy and diagnosis; structural features of various types of antibodies; dissection of antibody-antigen interactions; in silico affinity maturation; manipulation of antigen specificity by point mutagenesis; using antibody Fc domain to modulate pharmacokinetics and effector functions; design of antibody conjugates carrying toxic payloads; engineering T-cells with chimeric antigen receptors; evaluation and improving antibody immunogenicity and aggregation; antibody humanization.
Terms: Fall 2021
Instructors: Salavati, Reza; Sulea, Traian (Fall)
Prerequisite: 400-level or higher level course in biochemistry and bioinformatics, or permission of instructor