Program Requirements
U1 Required Courses (14 credits)

BIOL 200 Molecular Biology (3 credits)
Overview
Biology (Sci) : The physical and chemical properties of the cell and its components in relation to their structure and function. Topics include: protein structure, enzymes and enzyme kinetics; nucleic acid replication, transcription and translation; the genetic code, mutation, recombination, and regulation of gene expression.
Terms: Fall 2015
Instructors: Thomas E Bureau, Richard D W Roy, Monique Zetka, Kenneth E M Hastings (Fall)

BIOL 309 Mathematical Models in Biology (3 credits)
Overview
Biology (Sci) : Application of finite difference and differential equations to problems in cell and developmental biology, ecology and physiology. Qualitative, quantitative and graphical techniques are used to analyze mathematical models and to compare theoretical predictions with experimental data.
Terms: Fall 2015
Instructors: Leon Glass (Fall)
Fall
3 hours lecture
Prerequisite: one year of calculus. An additional course in calculus is recommended

MATH 222 Calculus 3 (3 credits)
Overview
Mathematics & Statistics (Sci) : Taylor series, Taylor's theorem in one and several variables. Review of vector geometry. Partial differentiation, directional derivative. Extreme of functions of 2 or 3 variables. Parametric curves and arc length. Polar and spherical coordinates. Multiple integrals.
Terms: Fall 2015, Winter 2016, Summer 2016
Instructors: Stephen W Drury, Jingyin Huang (Fall) Stephen W Drury (Winter) Geoffrey McGregor (Summer)

PHGY 212 Introductory Physiology Laboratory 1 (1 credit)
Overview
Physiology : Exercises illustrating fundamental principles in physiology: Biological Signals Acquisitions, Blood, Immunology, Neurophysiology, Neuromuscular Physiology.
Terms: Fall 2015
Instructors: Julio Martinez Trujillo, Mladen I Glavinovic, Kresimir Krnjevic, Melissa Vollrath, Nicole F Bernard (Fall)
(One 3hour lab and one 1hour lecture every second week.)
Corequisite: PHGY 209.
Restrictions: Required for Physiology students enrolled in PHGY 209. Open to BA &Sc. students and to others by permission of the instructor. Not open to students who have taken PHGY 212D1/D2.
Note: For students in a Physiology program, PHGY 212 should be taken concurrently with PHGY 209.

PHGY 213 Introductory Physiology Laboratory 2 (1 credit)
Overview
Physiology : Exercises illustrating fundamental principles in physiology: Central Nervous System, Cardiovascular, Respiration, Exercise Physiology, Molecular Endocrinology.
Terms: Winter 2016
Instructors: Michael R Guevara, Jacopo Mortola, John H White, Douglas Watt (Winter)
(One 3hour lab and one 1hour lecture every second week.)
Prerequisite: PHGY 212
Corequisite: PHGY 210.
Restrictions: Required for Physiology students enrolled in PHGY 210. Open to BA &Sc. students and to others by permission of the instructor. Not open to students who have taken PHGY 212D1/D2.
Note: For students in a Physiology program, PHGY 213 should be taken concurrently with PHGY 210.
One of:

MATH 223 Linear Algebra (3 credits)
Overview
Mathematics & Statistics (Sci) : Review of matrix algebra, determinants and systems of linear equations. Vector spaces, linear operators and their matrix representations, orthogonality. Eigenvalues and eigenvectors, diagonalization of Hermitian matrices. Applications.
Terms: Fall 2015, Winter 2016
Instructors: Thomas F Fox (Fall) Michael Pichot (Winter)

MATH 247 Honours Applied Linear Algebra (3 credits)
Overview
Mathematics & Statistics (Sci) : Matrix algebra, determinants, systems of linear equations. Abstract vector spaces, inner product spaces, Fourier series. Linear transformations and their matrix representations. Eigenvalues and eigenvectors, diagonalizable and defective matrices, positive definite and semidefinite matrices. Quadratic and Hermitian forms, generalized eigenvalue problems, simultaneous reduction of quadratic forms. Applications.
Terms: Winter 2016
Instructors: Daniel Disegni (Winter)
U1 Complementary Courses (15 credits)
3 credits, one of:

BIOC 212 Molecular Mechanisms of Cell Function (3 credits)
Overview
Biochemistry : An introductory course describing the biochemistry and molecular biology of selected key functions of animal cells, including: gene expression; mitochondrial production of metabolic energy; cellular communication with the extracellular environment; and regulation of cell division.
Terms: Winter 2016
Instructors: Thomas Duchaine, Philip E Branton, Maxime Bouchard (Winter)

BIOL 201 Cell Biology and Metabolism (3 credits)
Overview
Biology (Sci) : This course introduces the student to our modern understanding of cells and how they work. Major topics to be covered include: photosynthesis, energy metabolism and metabolic integration; plasma membrane including secretion, endocytosis and contact mediated interactions between cells; cytoskeleton including cell and organelle movement; the nervous system; hormone signaling; the cell cycle.
Terms: Winter 2016
Instructors: Gregory G Brown, Richard D W Roy, Joseph Alan Dent (Winter)
6 credits selected as follows:

PHGY 209 Mammalian Physiology 1 (3 credits)
Overview
Physiology : Physiology of body fluids, blood, body defense mechanisms, muscle, peripheral, central, and autonomic nervous systems.
Terms: Fall 2015
Instructors: Melissa Vollrath, Phil Gold, Ann Wechsler (Fall)
Fall
3 hours lectures weekly
Prerequisites: BIOL 112, CHEM 110, CHEM 120, PHYS 101 or PHYS 131, and PHYS 102 or PHYS 142. Pre/corequisites: BIOL 200, CHEM 212 or equivalent.
Restriction: Not open to students who have taken PHGY 211 or students who are taking and who have taken NSCI 200.
Restriction: For students in the Faculty of Science, and other students by permission of the instructor

PHGY 210 Mammalian Physiology 2 (3 credits)
Overview
Physiology : Physiology of cardiovascular, respiratory, digestive, endocrine and renal systems.
Terms: Winter 2016
Instructors: John H White, Tomoko Takano, Michael R Guevara (Winter)
Winter
3 hours lectures weekly
Prerequisites: BIOL 112, CHEM 110, CHEM 120, PHYS 101 or PHYS 131, and PHYS 102 or PHYS 142. Pre/corequisite: BIOL 200, BIOL 201, BIOC 212, CHEM 212 or equivalent.
Restriction: For students in the Faculty of Science, and other students by permission of the instructor
Although PHGY 210 may be taken without the prior passing of PHGY 209, students should note that they may have some initial difficulties because of lack of familiarity with some basic concepts introduced in PHGY 209
3 credits, one of:

MATH 248 Honours Advanced Calculus (3 credits)
Overview
Mathematics & Statistics (Sci) : Partial derivatives; implicit functions; Jacobians; maxima and minima; Lagrange multipliers. Scalar and vector fields; orthogonal curvilinear coordinates. Multiple integrals; arc length, volume and surface area. Line integrals; Green's theorem; the divergence theorem. Stokes' theorem; irrotational and solenoidal fields; applications.
Terms: Fall 2015
Instructors: Pengfei Guan (Fall)

MATH 314 Advanced Calculus (3 credits)
Overview
Mathematics & Statistics (Sci) : Derivative as a matrix. Chain rule. Implicit functions. Constrained maxima and minima. Jacobians. Multiple integration. Line and surface integrals. Theorems of Green, Stokes and Gauss. Fourier series with applications.
Terms: Fall 2015, Winter 2016
Instructors: Annalisa Panati (Fall) Charles Roth (Winter)
3 credits, one of:

MATH 315 Ordinary Differential Equations (3 credits)
Overview
Mathematics & Statistics (Sci) : First order ordinary differential equations including elementary numerical methods. Linear differential equations. Laplace transforms. Series solutions.
Terms: Fall 2015, Winter 2016, Summer 2016
Instructors: JianJun Xu (Fall) Xinyang Lu (Winter) Charles Roth (Summer)

MATH 325 Honours Ordinary Differential Equations (3 credits)
Overview
Mathematics & Statistics (Sci) : First and second order equations, linear equations, series solutions, Frobenius method, introduction to numerical methods and to linear systems, Laplace transforms, applications.
Terms: Fall 2015, Winter 2016
Instructors: JunFang Li (Fall) Antony Raymond Humphries (Winter)
U2 Required Courses (24 credits)

MATH 242 Analysis 1 (3 credits)
Overview
Mathematics & Statistics (Sci) : A rigorous presentation of sequences and of real numbers and basic properties of continuous and differentiable functions on the real line.
Terms: Fall 2015
Instructors: Axel W Hundemer (Fall)

MATH 243 Analysis 2 (3 credits)
Overview
Mathematics & Statistics (Sci) : Definition and properties of Riemann integral, Fundamental Theorem of Calculus, Taylor's theorem. Infinite series: alternating, telescoping series, rearrangements, conditional and absolute convergence, convergence tests. Power series and Taylor series. Elementary functions. Introduction to metric spaces.
Terms: Winter 2016
Instructors: Axel W Hundemer (Winter)

MATH 323 Probability (3 credits)
Overview
Mathematics & Statistics (Sci) : Sample space, events, conditional probability, independence of events, Bayes' Theorem. Basic combinatorial probability, random variables, discrete and continuous univariate and multivariate distributions. Independence of random variables. Inequalities, weak law of large numbers, central limit theorem.
Terms: Fall 2015, Winter 2016, Summer 2016
Instructors: William J Anderson (Fall) Irene Vrbik (Winter) Djivede Kelome (Summer)

MATH 326 Nonlinear Dynamics and Chaos (3 credits)
Overview
Mathematics & Statistics (Sci) : Linear systems of differential equations, linear stability theory. Nonlinear systems: existence and uniqueness, numerical methods, one and two dimensional flows, phase space, limit cycles, PoincareBendixson theorem, bifurcations, Hopf bifurcation, the Lorenz equations and chaos.
Terms: Fall 2015
Instructors: JeanChristophe Nave (Fall)

PHGY 311 Channels, Synapses & Hormones (3 credits)
Overview
Physiology : Indepth presentation of experimental results and hypotheses on cellular communication in the nervous system and the endocrine system.
Terms: Fall 2015
Instructors: Ellis Cooper, Per Jesper Sjostrom, Reza Sharif Naeini (Fall)
Fall
3 hours of lectures per week; 13 hours optional lab/demonstration/tutorial arranged for a maximum of 3 afternoons per term
Prerequisite: PHGY 209 or permission of the instructor.

PHGY 312 Respiratory, Renal, & Cardiovascular Physiology (3 credits)
Overview
Physiology : Indepth presentation of experimental results and hypotheses underlying our current understanding of topics in renal, respiratory and cardiovascular functions explored beyond the introductory level.
Terms: Winter 2016
Instructors: John W Hanrahan, Jacopo Mortola, Alvin Shrier (Winter)

PHGY 313 Blood, Gastrointestinal, & Immune Systems Physiology (3 credits)
Overview
Physiology : Indepth presentation of experimental results and hypotheses underlying our current understanding of topics in immunology, blood and fluids, and gastrointestinal physiology.
Terms: Winter 2016
Instructors: Russell Jones, Volker Manfred Blank, Maia Kokoeva (Winter)

PHGY 314 Integrative Neuroscience (3 credits)
Overview
Physiology : In depth presentation of experimental results and hypotheses underlying our current understanding of how single neurons and ensembles of neurons encode sensory information, generate movement, and control cognitive functions such as emotion, learning, and memory, during voluntary behaviours.
Terms: Fall 2015
Instructors: Kathleen E Cullen, Reza Sharif Naeini, Erik Cook (Fall)
Fall
3 hours of lectures per week
Prerequisites: PHGY 209
U2 or U3 Required Courses (6 credits)

MATH 437 Mathematical Methods in Biology (3 credits)
Overview
Mathematics & Statistics (Sci) : The formulation and treatment of realistic mathematical models describing biological phenomena through qualitative and quantitative mathematical techniques (e.g. local and global stability theory, bifurcation analysis and phase plane analysis) and numerical simulation. Concrete and detailed examples will be drawn from molecular and cellular biology and mammalian physiology.
Terms: Winter 2016
Instructors: Anmar Khadra (Winter)

PHYS 413 Physical Basis of Physiology (3 credits)
Overview
Physics : Analytic and computer simulation techniques are used to examine the role of nonlinearities and time delays in determining the dynamic behaviour of physiological control systems and their relation to normal and pathophysiological states. Examples drawn from the control of respiration, cellular proliferation and differentiation, biochemical feedback networks, thermoregulatory mechanisms, and neural feedback.
Terms: This course is not scheduled for the 20152016 academic year.
Instructors: There are no professors associated with this course for the 20152016 academic year.
U3 Required Courses (18 credits)

BMDE 519 Biomedical Signals and Systems (3 credits)
Overview
Biomedical Engineering : An introduction to the theoretical framework, experimental techniques and analysis procedures available for the quantitative analysis of physiological systems and signals. Lectures plus laboratory work using the Biomedical Engineering computer system. Topics include: amplitude and frequency structure of signals, filtering, sampling, correlation functions, time and frequencydomain descriptions of systems.
Terms: Fall 2015
Instructors: Robert E Kearney (Fall)
(306)
Prerequisites: Satisfactory standing in U3 Honours Physiology; or U3 Major in PhysicsPhysiology; or U3 Major PhysiologyMathematics; or permission of instructor

MATH 319 Introduction to Partial Differential Equations (3 credits)
Overview
Mathematics & Statistics (Sci) : First order equations, geometric theory; second order equations, classification; Laplace, wave and heat equations, SturmLiouville theory, Fourier series, boundary and initial value problems.
Terms: Winter 2016
Instructors: Gantumur Tsogtgerel (Winter)

MATH 324 Statistics (3 credits)
Overview
Mathematics & Statistics (Sci) : Sampling distributions, point and interval estimation, hypothesis testing, analysis of variance, contingency tables, nonparametric inference, regression, Bayesian inference.
Terms: Fall 2015, Winter 2016
Instructors: Johanna Neslehova (Fall) Christian Genest (Winter)
Fall and Winter
Prerequisite: MATH 323 or equivalent
Restriction: Not open to students who have taken or are taking MATH 357
You may not be able to receive credit for this course and other statistic courses. Be sure to check the Course Overlap section under Faculty Degree Requirements in the Arts or Science section of the Calendar.

PHGY 461D1 Experimental Physiology (4.5 credits)
Overview
Physiology : Individual project work under the supervision of Departmental Staff members.
Terms: Fall 2015
Instructors: Ann Wechsler, Linda H Cooper (Fall)
Fall
Restrictions: Departmental approval required. This course is a requirement for U3 students in the Honours Physiology program, the Major Program in Physiology and Mathematics, and the Major program in Physiology and Physics, and is open to a limited number of other U3 Physiology students.
Students must register for both PHGY 461D1 and PHGY 461D2.
No credit will be given for this course unless both PHGY 461D1 and PHGY 461D2 are successfully completed in consecutive terms

PHGY 461D2 Experimental Physiology (4.5 credits)
Overview
Physiology : See PHGY 461D1 for course description.
Terms: Winter 2016
Instructors: Ann Wechsler (Winter)
Winter
Prerequisite: PHGY 461D1
No credit will be given for this course unless both PHGY 461D1 and PHGY 461D2 are successfully completed in consecutive terms