Canada Research Chair (tier 2)
Regular Member, CRBLM
nicole.li [at] mcgill.ca (Email)
BSc Honors Speech and Hearing Sciences, University of Hong Kong
Dr. Li-Jessen’s laboratory integrates in vitro, in vivo and in silico (computational) approaches to study vocal fold biology and wound healing. The research goal is to generate a computational platform that can guide surgeons and speech pathologists in the best methods to repair voices that have been lost. Current research projects focus on what cells and proteins drive the vocal fold injury and repair after surgical and vocal trauma, along with the roles of biomechanical stress in cellular and tissue adaptation. Our lab uses agent-based modeling to simulate patient-specific vocal trauma and repair response in computers. In addition, we work in collaboration with engineers and surgeons to develop non-invasive assessment of vocal fold pathology and create biomaterial for vocal fold reconstruction.
Seekhao, N., Jaja, J. Mongeau, L. & Li-Jessen, N. Y. K. (in press). In situ visualization for 3D agent-based vocal fold inflammation and repair simulation. Supercomputing Frontiers and Innovations.
Imaizumi, M., Li-Jessen, N. Y. K., Sato, Y., Yang, D. Y. & Thibeault, S. L. (2017). Retention of human-induced pluripotent stem cells (hiPS) with injectable HA-hydrogels for vocal fold tissue engineering. Annals of Otology, Rhinology & Laryngology, 126(4), 304-314.
Li-Jessen, N. Y. K., Powell, M., Choi, A. J., Lee, B. J., & Thibeault, S. L. (2016). Cellular source and pro-inflammatory roles of high mobility group box 1 in surgically injured rat vocal folds. Laryngoscope, 127(6), E198-E200.
Latifi, N., Heris, H. K., Thomson, S. L., Taher, R., Kazemirad, S., Sheibani, S., Li-Jessen, N. Y. K., Hojatollah, V. & Mongeau, L. (2016). A Flow Perfusion Bioreactor System for Vocal Fold Tissue Engineering Applications. Tissue Engineering Part C: Methods, 22(9), 823-838.
Seekhao, N., Shung, C., JaJa, J., Mongeau, L. & Li-Jessen, N. Y. K. (2016). Real-time agent-based modeling simulation with in-situ visualization of complex biological systems - a case study on vocal fold inflammation and healing. IEEE HiCOMB, 463-472.