Studying mechanisms of repair following neonatal hypoxia-ischemia - NSCI 396 Undergraduate Research Project Application Form

Supervisor's Name: Dr. Pia Wintermark

Supervisor's Email: pia.wintermark [at] mcgill.ca

Supervisor's Phone: 5144424452

Supervisor's Website: www.neobrainlab.org

Supervisor's department: Neuroscience

Course number: NSCI 396 (Neuroscience)

Term: Winter 2018

Project start date: Monday, January 8, 2018

Project end date: Monday, April 16, 2018

Project title: Studying mechanisms of repair following neonatal hypoxia-ischemia

Project description (50-100 words suggested): Asphyxiated newborns treated with hypothermia remain at risk to develop brain injury despite the treatment. Our lab has shown the beneficial effects of sildenafil on brain and retina injury following neonatal hypoxia-ischemia. However, the involved mechanisms explaining these beneficial effects have not yet been identified. We hypothesize that the beneficial effects of sildenafil include cell regeneration rather than limitation of cell death. The involved student will investigate this hypothesis by studying mechanisms of cell death and cell regeneration.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): 10% for the Proposal Abstract; 40% for the Final Written Report; 50% for Laboratory Performance

Other project information: The proposed project will allow the assigned student to develop skills in the field of neonatal neurology. The student will review pertinent literature on the research topic. She will collect the data required for her research project, analyze and interpret the results,and write a report. Additionally to the above tasks, the student will present her own data to lab meeting and write an experimental report. If experimental data obtained warrants it, she will contribute to the writing of an abstract to be presented at a scientific meeting or to be submitted as a scientific paper.

Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves NEITHER animal subjects, nor human subjects, nor biohazardous substances, nor radioactive materials, nor handling chemicals, nor using lasers.