Development of Neuronal Populations in Mammalian Forebrain - NSCI 396 Undergraduate Research Project Application Form

Supervisor's Name: Abbas Sadikot

Supervisor's Email: abbas.sadikot [at] mcgill.ca

Supervisor's Phone: 514-398-8037

Supervisor's Website:

Supervisor's department: Neurology and Neurosurgery

Course number: NSCI 396 (Neuroscience)

Term: Winter 2018

Project start date: Monday, January 8, 2018

Project end date: Monday, April 16, 2018

Project title: Development of Neuronal Populations in Mammalian Forebrain

Project description (50-100 words suggested): The mammalian striatum is the core structure of the basal ganglia network and mediates motor, cognitive and limbic functions. The principal neurons of the striatum are the medium spiny neurons (MSPs). 2 major populations of MSPs give rise to projections that contact either the external or internal pallidal segments. This organization is an important guiding principle behind basal ganglia function. Little information is available on whether direct or indirect pathway MSPs arise from separate neuronal precursors or whether they have a common precursor during brain development. The goal of the project is to determine if the 2 populations are produced at different times, or if their neurogenesis periods are virtually identical. The project uses well-established anatomical birth-dating methods to determine neurogenesis periods, and transgenic mice that express separate fluorescent proteins in the 2 populations of MSPs.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final Report, 50%. Quantity and quality of lab participation, 40%. Oral presentation to the lab, 10%. (Final report- 10-15 pages excluding figures and references.)

Project status: This project is taken.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects.