Development of a live, attenuated Salmonella-based vaccine against Schistosoma mansoni - MIMM 396 Undergraduate Research Project Application Form

Supervisor's Name: Dr. Momar Ndao

Supervisor's Email: momar.ndao [at] mcgill.ca

Supervisor's Phone:

Supervisor's Website:

Supervisor's department: Microbiology and Immunology

Course number: MIMM 396 (Microbiology)

Term: Winter 2018

Project start date: Monday, January 8, 2018

Project end date: Monday, April 16, 2018

Project title: Development of a live, attenuated Salmonella-based vaccine against Schistosoma mansoni

Project description (50-100 words suggested): Schistosomiasis is a fresh-water-borne parasitic disease caused by trematode worms of the genus Schistosoma. With over 200 million people infected worldwide and approximately 700 million people at risk of infection, the World Health Organization considers schistosomiasis as the most important human helminth infection. This project's purpose is to develop a novel vaccine targeting Schistosoma mansoni, one of the three main causative species of schistosomiasis. Using the live, attenuated YS1646 strain of Salmonella typhimurium as a vector, the host's immune system is expected to be stimulated by the antigen Cathepsin B.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.

How students can apply / Next steps: For MIMM: After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to Prof. Gregory Marczynski during office hours, who will review/approve as the course coordinator for MIMM 396 (Microbiology) or MIMM 397 (Immunology).

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Biohazardous substances.