Characterization of the cellular and molecular mechanisms involved in host-pathogen interaction in Salmonella-susceptible mice - HGEN 396 Undergraduate Research Project Application Form

Supervisor's Name: Danielle Malo

Supervisor's Email: danielle.malo [at] mcgill.ca

Supervisor's Phone: 5143346207

Supervisor's Website: https://mcgill.ca/mrcct/members/primary-members/danielle-malo

Supervisor's department: Human Genetics

Supervisor's department (if none of the above):

Course number: HGEN 396 (Human Genetics)

Term: Winter 2018

Project start date: Monday, January 8, 2018

Project end date: Monday, April 16, 2018

Project title: Characterization of the cellular and molecular mechanisms involved in host-pathogen interaction in Salmonella-susceptible mice

Project description (50-100 words suggested): The current project is making use of mice of the collaborative cross (CC) as a new resource to study the interaction between the host and Salmonella. The CC is a large panel of inbred mice derived from eight founder strains and interrogates multiple genes at the same time to reveal unsuspected gene functions and gene network relationships. This project will focus on cellular and molecular phenotyping of CC deviant strains by using primary cell culture models of Salmonella infection combined with gene expression (qPCR and Western blot) experiments.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade is based on an evaluation of laboratory performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor.

Project status: This project is taken.

How students can apply / Next steps: For HGEN: After all of the parts of this application forms are completed and the hard copy is signed by the professor and the student, return the application form with a copy of your unofficial transcript to Mr Ross MacKay in the Department of Human Genetics (electronically or hardcopy; see www.mcgill.ca/humangenetics/about-us for contact information).

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Biohazardous substances; Handling chemicals.