Structural Analysis of Lysosomal Proteins - BIOC 396 Undergraduate Research Project Application Form

Supervisor's Name: Bhushan Nagar

Supervisor's Email: bhushan.nagar [at] mcgill.ca

Supervisor's Phone:

Supervisor's Website:

Supervisor's department: Biochemistry

Course number: BIOC 396 (Biochemistry)

Term: Winter 2018

Project start date: Monday, January 8, 2018

Project end date: Monday, April 16, 2018

Project title: Structural Analysis of Lysosomal Proteins

Project description (50-100 words suggested): Lysosomes are organelles found in most cells and contain a plethora of hydrolytic enzymes that degrade various macromolecules. Lysosomal storage diseases are a class of diseases caused by mutations in lysosomal protein structure, causing their inability to degrade their substrates and consequent buildup of such substrates in cells. This project focuses on the analysis of lysosomal protein structures obtained through x-ray crystallography using various software, as well as learning to use the technologies associated with protein crystallography.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade will be based on an evaluation of laboratory performance (50%) and a final written report (50%).

Project status: This project is taken.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances; Handling chemicals.