Alteration of cortical plasticity in Alzheimer's disease - PHAR 396 Undergraduate Research Project Application Form

Supervisor's Name: Tak Pan Wong

Supervisor's Email: tak.wong [at]

Supervisor's Phone: 514-761-6131 ext 2929

Supervisor's Website:

Supervisor's department: Pharmacology

Course number: PHAR 396 (Pharmacology - first offered in September 2014)

Term: Fall 2014-2015

Project start date: September 2, 2014

Project end date: December 4, 2014

Project title: Alteration of cortical plasticity in Alzheimer's disease

Project description (50-100 words suggested): Alzheimer's disease (AD) is the most common cause of dementia. Cognitive impairment in AD could be due to impairment of the plastic properties of the cerebral cortex. Using CRND8 mice, a transgenic AD model that overexpresses mutated gene of amyloid precursor protein, we will examine whether they display changes in TNFalpha, a cytokine that regulates brain development and synaptic plasticity, in the visual cortex. Next, we will determine if plastic changes in TNFalpha levels caused by dark rearing is affected in CRND8 mice. Findings from these studies could reveal a largely unknown alteration of cortical plasticity in CRND8 mice.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): A written report for 50% and 50% based on performance in the lab

Other project information: This project involves animal works.

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects.