May Sildenafil Repair Premature Brains Exposed to Hyperoxia - NSCI 396 Undergraduate Research Project Application Form

Supervisor's Name: Pia Wintermark

Supervisor's Email: pia.wintermark [at] mcgill.ca

Supervisor's Phone: 514-412-4452

Supervisor's Website: www.neobrainlab.org

Supervisor's department: Department of Pediatrics

Course number: NSCI 396 (Neuroscience)

Term: Fall 2014-2015

Project start date: September 2nd, 2014

Project end date: December 4th, 2014

Project title: May Sildenafil Repair Premature Brains Exposed to Hyperoxia

Project description (50-100 words suggested): Retinopathy of prematurity is a retinal disease developing in premature newborns exposed to prolonged mechanical ventilation. Our hypothesis is that oxygen toxicity (hyperoxia) associated with retinopathy of prematurity is also the responsible mechanism of damage to the developing brain in these patients. We will use a known rodent model of retinopathy of prematurity. We will perform histological and immunohistochemical analyses to compare infarct volume, neurogenesis and angiogenesis between rats brains exposed or not to hyperoxia, and treated or not with sildenafil. This will provide a better understanding of why brain injuries develop in these premature newborns exposed to prolonged mechanical ventilation and if sildenafil could be a possible treatment.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade by the supervisor shall be based on an evaluation of laboratory performance (40%), a final written report (50%), and an oral presentation (10%).

Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects.