Activation and dimerization of parkin - NSCI 396 Undergraduate Research Project Application Form

Supervisor's Name: Edward Fon

Supervisor's Email: ted.fon [at] mcgill.ca

Supervisor's Phone: 514-398-8398

Supervisor's Website: http://edwardfon.lab.mcgill.ca

Supervisor's department (if none of the above): Neurology and Neurosurgery

Course number: NSCI 396 (Neuroscience)

Term: Fall 2014-2015

Project start date: September 2, 2014

Project end date: December 4, 2014

Project title: Activation and dimerization of parkin

Project description (50-100 words suggested): Parkin is an E3 ubiquitin ligase that is mutated in familial Parkinson's disease. The student will test various mutants of parkin in cells to characterize the mechanism of dimerization,  E3 ubiquitin ligase activity and function in mitochondrial quality control..

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor.

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Handling chemicals