Social defeat mouse model - NSCI 396 Undergraduate Research Project Application Form

Supervisor's Name: Cecilia Flores

Supervisor's Email: cecilia.flores [at] mcgill.ca

Supervisor's Phone: 514 761 6131 x 2814

Supervisor's Website: http://ceciliafloreslab.com

Supervisor's department: Psychiatry

Course number: NSCI 396 (Neuroscience)

Term: Fall 2014-2015

Project start date: September 2, 2014

Project end date: December 10, 2014

Project title: Social defeat mouse model

Project description (50-100 words suggested): The aim of this project is to assessed whether the guidance cue receptor gene, dcc, plays a role in chronic stress-induced social defeat in adult mice. To this end, dcc will be knockdown in selective neurons of the medial prefrontal cortex of adult mice before exposing them to chronic stress using viral vectors. Behavioral and neuroanatomical quantitative analyses will be conducted. The student will assist with the behavioral and immunofluorescent experiments and will verify and quantify the extent of the dcc deletion in pyramidal cortical neurons.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (20 pages) graded by the research supervisor (50%).

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects.