S. aureus regulates staphylococcal superantigen-induced IP-10 production in different antigen-presenting cells - MIMM 397 Undergraduate Research Project Application Form

Supervisor's Name: Joaquin Madrenas

Supervisor's Email: joaquin.madrenas [at] mcgill.ca

Supervisor's Phone: 3914

Supervisor's Website: https://mcgill.ca/microimm

Supervisor's department: Microbiology and Immunology

Course number: MIMM 397 (Immunology)

Term: Fall 2014-2015

Project start date: September 2, 2014

Project end date: December 4, 2014

Project title: S. aureus regulates staphylococcal superantigen-induced IP-10 production in different antigen-presenting cells

Project description (50-100 words suggested): We have demonstrated that chemokine IP-10 is produced under the stimulation of superantigen in human PBMC. The IP-10 producing cells are monocytes and T cells. Furthermore, superantigen-induced IP-10 production is inhibited by S.aureus. For this project, it is interesting to determine the capacity of IP-10 production by macrophage and dendritic cell, both derived from monocytes; and whether IP-10 production is inhibited by S.aureus in these cells. Moreover, it is also interesting to study IP-10 trafficking and see if IP-10 secretion is inhibited by S.aureus.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%)

Project status: This project is taken. The professor has no more '396' projects this term.

How students can apply / Next steps: After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to Prof. Gregory Marczynski during office hours, who will review/approve as the course coordinator for MIMM 396 (Microbiology) or MIMM 397 (Immunology).

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Handling chemicals.