miRNA expression in differentially-activated dendritic cells - MIMM 397 Undergraduate Research Project Application Form

Supervisor's Name: Connie Krawczyk

Supervisor's Email: connie.krawczyk [at] mcgill.ca

Supervisor's Phone: x1376

Supervisor's Website:

Supervisor's department: Microbiology and Immunology

Course number: MIMM 397 (Immunology)

Term: Fall 2014-2015

Project start date: September 2, 2014

Project end date: December 15, 2014

Project title: miRNA expression in differentially-activated dendritic cells

Project description (50-100 words suggested): Dendritic cells become differentially activated depending on the type of stimulus they encounter. The activation phenotype depends on regulation of gene expression at both the level of transcription and translation. Recently, miRNAs have been shown to key regulators of gene expression by either silencing mRNA translation or targeting mRNA for degradation. We propose to characterize the differential expression of miRNAs following treatment of dendritic cells with various stimuli. miRNAs of interested will be identified and followed up for functional analysis.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): final report 50%; research performance 50%.

Project status: This project is taken. The professor has no more '396' projects this term.

How students can apply / Next steps: For MIMM: After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to Prof. Gregory Marczynski during office hours, who will review/approve as the course coordinator for MIMM 396 (Microbiology) or MIMM 397 (Immunology).

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Biohazardous substances; Handling chemicals.