Characterization of regulatory polymorphisms associated with type 2 diabetes - HGEN 396 Undergraduate Research Project Application Form

Supervisor's Name: Rob Sladek

Supervisor's Email: robert.sladek [at]

Supervisor's Phone:

Supervisor's Website:

Supervisor's department: Human Genetics

Course number: HGEN 396 (Human Genetics)

Term: Fall 2014-2015

Project start date: 1 September 2014

Project end date: 4 December 2014

Project title: Characterization of regulatory polymorphisms associated with type 2 diabetes

Project description (50-100 words suggested): Approximately two-thirds of the risk loci identified for type 2 diabetes appear to occur in non-coding regions of the genome and are thought to alter gene transcription. The aim of this project is to use bioinformatics and wet-lab techniques to identify transcription factors whose activity is altered by diabetes-associated polymorphisms. The bioinformatics analysis will make use of public datasets provided by the NIH ENCODE and Roadmap Epigenomics Projects. The wet-lab experiments will follow the approach recently described by B.K. Cornes et al in Circulation Research (Cardovascular Genomics) 7:374-82. Up to three loci will be evaluated in the lab based on the strength of the supporting evidence in the public datasets.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor. Details of the evaluation scheme will be provided by HGEN to supervisors and applicants.

Project status: This project is taken. The professor has no more '396' projects this term.

How students can apply / Next steps: After all of the parts of this application forms are completed and the hard copy is signed by the professor and the student, bring the application form and a copy of your unofficial transcript to the Department of Human Genetics (to the attention of Dr. Patricia N. Tonin, Stewart Biology Building N5.13) during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances.