Supervisor's Name: Youla S. Tsantrizos
Supervisor's Email: youla.tsantrizos [at] mcgill.ca
Supervisor's Phone: 398-3638
Supervisor's department: Chemistry
Course number: CHEM 396 (Chemistry)
Term: Fall 2014-2015
Project start date: September 5, 2014
Project end date: December 5, 2014
Project title: Synthesis of HIV RT Inhibitors
Project description (50-100 words suggested): Virally-encoded nucleic acid processing enzymes represent a large family of valuable therapeutic targets. Important examples include the human immunodeficient virus 1 (HIV-1) reverse transcriptase (RT). Nucleosides and nucleoside mimics bind at the active site of this viral polymerase and inhibit replication of the HIV-1 by blocking oligonucleotide chain elongation. The student will work closely with a post-doctoral fellow to identify PPi bioisosteres that block viral replication by inhibiting the HIV-1 RT nuclei acid processing enzymes.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): 25% lab work, 25% presentations at group meetings, 50% final reposrt
Project status: This project is taken. The professor has no more '396' projects this term.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves NEITHER animal subjects, nor human subjects, nor biohazardous substances, nor radioactive materials, nor handling chemicals, nor using lasers.