Synthesis of HIV RT Inhibitors - CHEM 396 Undergraduate Research Project Application Form

 Supervisor's Name: Youla S. Tsantrizos

Supervisor's Email: youla.tsantrizos [at]

Supervisor's Phone: 398-3638

Supervisor's Website:

Supervisor's department: Chemistry

Course number: CHEM 396 (Chemistry)

Term: Fall 2014-2015

Project start date: September 5, 2014

Project end date: December 5, 2014

Project title: Synthesis of HIV RT Inhibitors

Project description (50-100 words suggested): Virally-encoded nucleic acid processing enzymes represent a large family of valuable therapeutic targets. Important examples include the human immunodeficient virus 1 (HIV-1) reverse transcriptase (RT). Nucleosides and nucleoside mimics bind at the active site of this viral polymerase and inhibit replication of the HIV-1 by blocking oligonucleotide chain elongation. The student will work closely with a post-doctoral fellow to identify PPi bioisosteres that block viral replication by inhibiting the HIV-1 RT nuclei acid processing enzymes.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): 25% lab work, 25% presentations at group meetings, 50% final reposrt

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves NEITHER animal subjects, nor human subjects, nor biohazardous substances, nor radioactive materials, nor handling chemicals, nor using lasers.