Structure-function analysis of Smoothened - ANAT 396 Undergraduate Research Project Application Form

Supervisor's Name: David Hipfner

Supervisor's Email: david.hipfner [at]

Supervisor's Phone: 514-987-5508

Supervisor's Website:

Supervisor's department: Anatomy and Cell Biology

Course number: ANAT 396 (Anatomy and Cell Biology)

Term: Winter 2014-2015

Project start date: Monday January 5, 2015

Project end date: Tuesday April 14, 2015

Project title: Structure-function analysis of Smoothened

Project description (50-100 words suggested): The G-protein-coupled receptor-like protein Smoothened is a crucial component of the Hedgehog signaling pathway that is misregulated in a variety of diseases, including cancer. In order to better understand how this pathway is regulated, we have generated several point mutant forms of Smo. Using cell-based assays, the student will assess the effects of these mutations on the ability of Smoothened to stimulate downstream target gene expression.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): The final grade will be based on three components: an evaluation of laboratory performance (40%), a final written report (50%), and an oral presentation in front of the supervisor and  members of the lab (10%).

Project status:  This project is taken; however students may contact the professor to discuss other possible '396' projects this term.

How students can apply / Next steps: Completed hard copy, signed by the professor and the student, should be presented to the Department for approval

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Handling chemicals.