NRAGE in Neuronal Development - NSCI 396 Undergraduate Research Project Application Form

Supervisor's Name: Phil Barker

Supervisor's Email: phil.barker [at]

Supervisor's Phone: 514-398-3064

Supervisor's Website:

Supervisor's department: Anatomy and Cell Biology

Course number: NSCI 396 (Neuroscience)

Term: Winter 2013-2014

Project start date: Monday, January 6, 2014

Project end date: Friday, April 11, 2014

Project title: NRAGE in Neuronal Development

Project description (50-100 words suggested): NRAGE is a cytosolic protein that mediates downstream induced by the p75 neurotrophin receptor. The project will determine whether dorsal root ganglion (DRG) sensory neurons derived from NRAGE null mice have defects in developmental programmed cell death. For this, DRG neuronal number in L4 DRGs from wild type and NRAGE null animals will be compared at embryonic day 15, postnatal day 1 and postnatal day 90. The student will be responsible for the paraffin sectioning of fixed ganglia, Nissl staining, stereological DRG counting, and data processing/statistical analysis. Using similar techniques and if time permits, the student will also evaluate changes in DRG-dependent  skin innervation by wild type and NRAGE null DRG neurons.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Attendance = 10%; Lab presentation = 30%; Final report = 60%

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Handling chemicals