'Characterization of Npc2 expression in chick embryos' - HGEN 396 Undergraduate Research Project Application Form

Supervisor's Name: Aimee Ryan

Supervisor's Email: aimee.ryan [at] mcgill.ca

Supervisor's Phone: 514-412-4400 ext. 22853

Supervisor's Website:

Supervisor's department: Human Genetics

Course number: HGEN 396 (Human Genetics)

Term: Winter 2013-2014

Project start date: Monday, January 6, 2014

Project end date: Friday, April 11, 2014

Project title: Characterization of Npc2 expression in chick embryos.

Project description (50-100 words suggested): The goal of this project is to examine the mRNA expression pattern of Npc2 in chick embryos by whole mount in situ hybridization.  Npc2 is involved in cholesterol transport in the cell and mutations in Npc2 have been identified in a subset of patients with Niemann-Pick disease.  The student will learn to dissect chick embryos, perform in situ hybridization, and then analyze and document the expression patterns.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor. Details of the evaluation scheme will be provided by HGEN to supervisors and applicants.

Project status: This project is taken.

How students can apply / Next steps: For HGEN: After all of the parts of this application forms are completed and the hard copy is signed by the professor and the student, bring the application form and a copy of your unofficial transcript to the Department of Human Genetics (to the attention of Dr. Patricia N. Tonin, Stewart Biology Building N5.13) during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Handling chemicals.