Transgenerational epigenetic effects in carriers of chromosomal translocations - HGEN 396 Undergraduate Research Project Application Form

Supervisor's Name: Anna Naumova

Supervisor's Email: anna.naoumova [at]

Supervisor's Phone: 8888-35906

Supervisor's Website:

Supervisor's department: Human Genetics

Course number: HGEN 396 (Human Genetics)

Term: Winter 2013-2014

Project start date: Monday, January 6, 2014

Project end date: Friday, April 11, 2014

Project title: Transgenerational epigenetic effects in carriers of chromosomal translocations

Project description (50-100 words suggested): During prophase I of meiosis homologous chromosomes pair, synapse and recombine. However, chromosomal rearrangements interfere with chromosomal synapsis. The result of failure to synapse is that unsynapsed regions are silenced by epigenetic mechanisms. This phenomenon is termed meiotic silencing.  The question that my laboratory is interested in is if the epigenetic marks of meiotic silencing persist through gametogenesis and are transmitted to embryos causing gene silencing in embryos and abnormal development. The independent study research project will require the student to conduct RNA fluorescent in situ hybridization (RNA FISH) on mouse gametes and preimplantation embryos to identify regions that have lost gene expression as a result of meiotic silencing.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor. Details of the evaluation scheme will be provided by HGEN to supervisors and applicants.

Other project information: The student should have a good knowledge of basic chemistry, genetics, and molecular biology, manual dexterity and enthusiasm for research.  The project will require mouse handling.

Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.

How students can apply / Next steps: For HGEN: After all of the parts of this application forms are completed and the hard copy is signed by the professor and the student, bring the application form and a copy of your unofficial transcript to the Department of Human Genetics (to the attention of Dr. Patricia N. Tonin, Stewart Biology Building N5.13) during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Handling chemicals.