'ZMPSTE24 inhibitors as senescence agonists for cancer therapy' - CHEM 396 Undergraduate Research Project Application Form

Supervisor's Name: Youla S. Tsantrizos

Supervisor's Email: youla.tsantrizos [at] mcgill.ca

Supervisor's Phone: 398-3638

Supervisor's Website:

Supervisor's department: Chemistry

Course number: CHEM 396 (Chemistry)

Term: Winter 2013-2014

Project start date: Monday, January 6, 2014

Project end date: Friday, April 11, 2014

Project title: ZMPSTE24 inhibitors as senescence agonists for cancer therapy

Project description (50-100 words suggested): Cellular senescence is a  permanent cell cycle arrest that halts oncogenesis and activate efficient anti tumor immune responses. The goal of our research is to identify senescence agonists that are inhibitors of the enzyme ZMPSTE24. One advantage of triggering senescence versus cell death in patients is the possibility that senescent cells organize antitumor immune responses, which has been so far experimentally documented in mouse models. In other words, a senescent agonist can in principle turns a tumor into a tumor vaccine.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): 25% group presentations (a minimum of one), 25% laboratory performance, 50% final written report

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves handling chemicals.