'Role of the aryl hydrocarbon receptor in cigarette smoke-induced lung inflammation' - MIMM 397 Undergraduate Research Project Application Form

Supervisor's Name: Carolyn Baglole

Supervisor's Email: carolyn.baglole [at] mcgill.ca

Supervisor's Phone: 514-398-3864

Supervisor's Website:

Supervisor's department: Medicine

Course number: MIMM 397 (Immunology)

Term: Fall 2013-2014

Project start date: Tuesday, September 3, 2013

Project end date: Tuesday, December 3, 2013

Project title: Role of the aryl hydrocarbon receptor in cigarette smoke-induced lung inflammation

Project description (50-100 words suggested): The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor previously defined for its role in mediating toxic responses to environmental contaminants such as dioxin. Recently, a physiological role of the AhR in attenuating inflammation has been identified, opening the possibility of therapeutically targeting the AhR to thwart excess inflammation. Using an in vivo model of cigarette smoke exposure, this project will aim to determine if pharmacological manipulation of AhR activity alters the lung inflammatory response to an acute smoke exposure regime.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Project status: This project is taken. The professor has no more '396' projects this term.

How students can apply: After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to Prof. Gregory Marczynski during office hours, who will review/approve as the course coordinator for MIMM 396 (Microbiology) or MIMM 397 (Immunology).

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Biohazardous substances; Handling chemicals.