'Screen for suppressors of BRaf induced senescence' - BIOL 396 Undergraduate Research Project Application Form

Supervisor's Name: David Dankort

Supervisor's Email: david.dankort [at] mcgill.ca

Supervisor's Phone: 398-2307

Supervisor's Website: http://dankort-lab.mcgill.ca/

Supervisor's department: Biology

Course number: BIOL 396 (Biology)

Term: Fall 2013-2014

Project start date: Tuesday, September 3, 2013

Project end date: Tuesday, December 3, 2013

Project title: Screen for suppressors of BRaf induced senescence.

Project description (50-100 words suggested): BRAFV600 is the earliest and most common genetic mutation detected in melanoma that on its own, somewhat paradoxically, appears insufficient for malignant conversion due to the induction of a sustained cell cycle arrest, termed oncogene induced senescence (OIS). This suggests additional genes must be mutated to permit the bypass of OIS.  Here we seek to identify such genes using shRNAs-containing libraries.  Candidates will be verified and characterized on a one by one basis.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (45%), a final written report (45%), and an oral presentation (10%) by the supervisor.

Project status: This project is taken. The professor has no more '396' projects this term.

How students can apply: After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to Susan Gabe (Stewart Biology W3/25B) or Nancy Nelson (W3/25) during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances; Handling chemicals.