'Establishing Mechanisms of Acquired Resistance to Met-inhibitor in Met-addicted Gastric Cancer Cell Lines' - BIOC 396 Undergraduate Research Project Application Form

Supervisor's Name: Dr. Morag Park

Supervisor's Email: morag.park [at] mcgill.ca

Supervisor's Phone: 514-398-5749

Supervisor's Website: https://mcgill.ca/biochemistry/about-us/department/faculty-members/park

Supervisor's department: Biochemistry

Course number: BIOC 396 (Biochemistry)

Term: Fall 2013-2014

Project start date: Tuesday, September 3, 2013

Project end date: Tuesday, December 3, 2013

Project title: Establishing Mechanisms of Acquired Resistance to Met-inhibitor in Met-addicted Gastric Cancer Cell Lines

Project description (50-100 words suggested): Signaling by the Met hepatocyte growth factor (HGF) receptor tyrosine kinase (RTK), activates several downstream signaling pathways that promote cell migration and invasive growth. As several Met inhibitors are presently in all three phases of clinical trials, and Met signaling is a means of escaping treatment by other targeted small-molecule kinase inhibitors, there exists a great need to determine the mechanisms through which cells may circumvent Met inhibition. The goal is to use genetic and biochemical techniques to identify such resistance mechanisms. This will be essential for developing multi-ponged therapeutic strategies that may prove more efficacious at combatting tumorigenesis.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Research report 50%; Laboratory performance 50%

Project status: This project is taken.

How students can apply: Bring a printed copy of this application form and your advising transcript to me during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves:Biohazardous substances; Handling chemicals.