'Single-Molecule Microscopy: Device Development and Simulation' - PHYS 396 Undergraduate Research Project Application Form

Supervisor's Name: Sabrina Leslie

Supervisor's Email: sabrina.leslie [at] mcgill.ca

Supervisor's Phone: 514 398 1835

Supervisor's Website: http://www.physics.mcgill.ca/leslielab/

Supervisor's department: Physics

Course number: PHYS 396 (Physics)

Term: Summer 2013

Project start date: TBC

Project end date: TBC

Project title: Single-Molecule Microscopy: Device Development and Simulation

Project description: The Leslie lab develops new microscopy tools which use nanoscale confinement to enable new kinds of biophysical measurements. By extending the accessible range of single-molecule imaging parameters -- to much longer timescales and higher molecular concentrations - these tools enable new studies of molecular dynamics and interactions under much closer to physiological conditions that current technologies. In support of its technology development, the Leslie lab performs numerical simulations of its new imaging devices using COMSOL Multiphysics. We are looking for an enthusiastic, bright, and computer savvy student for this 396 project who is interested in extending these simulations, with guidance from both Prof Leslie and the M.Sc. student who developed the simulations initially. The project includes simulating the mechanical properties and geometry of a tuneable imaging chamber, as well as sample insertion / fluid flow in nano scale environments. Ideally the student would have some experience in finite element analysis, be comfortable and skilled in physics, mathematics, and computer science, and be interested in biophysics and microscopy. The predictions of the simulations will be implemented and tested in our lab so the student could possibly gain microscopy experience in this process, depending on the time-frame of the simulations. An example report on our device simulations to-date, which convey a clear idea of the project, is available upon request from Dr. Leslie.

Interested students are encouraged to send their CV and transcript by email to Prof. Leslie.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): 15% - Lab performance and lab book; 15% - Mid Term Report; 20% - Oral Presentation ~ 20 mins max.; 50% - Final Paper. ~ 20 pages max.

Project status: This project is open to applicant.

How students can apply: Contact professor by email; see project description.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves NEITHER animal subjects, nor human subjects, nor biohazardous substances, nor radioactive materials, nor handling chemicals, nor using lasers.