Supervisor's Name: Alfredo Ribeiro-da-Silva
Supervisor's Email: alfredo.ribeirodasilva [at] mcgill.ca
Supervisor's Phone:
Supervisor's Website:
Supervisor's department: Pharmacology
Course number: PHAR 396 (Pharmacology)
Term: Winter 2015-2016
Project start date: Thursday, January 7, 2016
Project end date: Friday, April 15, 2016
Project title: Changes in nerve fibre density in the rat osteoarthritic ankle joint following MIA intra-articular injection
Project description (50-100 words suggested): Mechanisms of osteoarthritic pain have been studied in the rat knee joint by intra-articular injections of the chondrocyte glycolytic inhibitor Mono-Iodoacetate (MIA). MIA-induced pain indicates that this model is clinically relevant and will continue to be useful for the development of better therapeutic strategies. The present study will investigate changes in nerve fiber density in the rat ankle joint following the injection of MIA (2.4 mg), using immunohistochemistry. Overall density of innervation will be assessed with an antibody for Protein Gene Product 9.5 (PGP 9.5), also known as ubiquitin C-terminal hydrolase 1 (UCHL-1).
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (40%) and a final written report (60%).
Project status: This project is taken. The professor has no more '396' projects this term.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects.