Effect of prenatal exposure to DINCH on offspring endocrine function - PHAR 396 Undergraduate Research Project Application Form

Supervisor's Name: Vassilios Papadopoulos

Supervisor's Email: vassilios.papadopoulos [at] mcgill.ca

Supervisor's Phone: 514-934-1934 ext. 44580

Supervisor's Website:

Supervisor's department: Pharmacology

Course number: PHAR 396 (Pharmacology)

Term: Fall 2015-2016

Project start date: Friday, September 4, 2015

Project end date: Monday, December 7, 2015

Project title: Effect of prenatal exposure to DINCH on offspring endocrine function

Project description (50-100 words suggested): 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH) is a plasticizer introduced in 2002 in the European market for use in plastic materials and articles intended to come into contact with food. DINCH received final approval from the European Food Safety Authority in 2006, nonetheless; there is limited knowledge about its potential endocrine-disrupting properties. Bisphenol A and phthalates, the most known classes of plasticizers, have been associated with the development of endocrine and reproductive diseases and different types of cancer. The purpose of the present work is to assess the effects of in utero exposure to DINCH on the male offspring endocrine function.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Written report for 50% and 50% based on performance in the lab

Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects.