Understanding G protein-coupled receptor conformational dynamics - PHAR 396 Undergraduate Research Project Application Form

Supervisor's Name: Terry Hébert

Supervisor's Email: terence.hebert [at] mcgill.ca

Supervisor's Phone: 5143981398

Supervisor's Website: http://www.medicine.mcgill.ca/pharma/hebertlab

Supervisor's department: Pharmacology

Course number: PHAR 396 (Pharmacology)

Term: Fall 2015-2016

Project start date: Friday, September 4, 2015

Project end date: Monday, December 7, 2015

Project title: Understanding G protein-coupled receptor conformational dynamics

Project description (50-100 words suggested): We propose to construct tools for examining receptor dynamics from different vantage points, to provide “FlAsHwalk maps”. Unlike studying the entire signalosome of receptors, FlAsHwalk maps provide information beyond signalling output and may be correlated to phenotypic signatures. Drug design may benefit from understanding of conformational dynamics, which are inherently ignored by the current structure-based design paradigms. Specifically, we propose to develop and functionally validate a panel of FlAsH-tagged receptor constructs at a number of sites within the intracellular domain of FP, the receptor for prostaglandin 2alpha.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%)/

Project status: This project is taken.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances.