The role of 5-hydroxymethylcytosine in suicide - HGEN 396 Undergraduate Research Project Application Form

Supervisor's Name: Dr. Gustavo Turecki

Supervisor's Email: gustavo.tuecki [at] mcgill.ca

Supervisor's Phone: 514-761-6131 x 2369

Supervisor's Website: www.mgss.ca

Supervisor's department: Psychiatry

Course number: HGEN 396 (Human Genetics)

Term: Fall 2015-2016

Project start date: Friday, September 4, 2015

Project end date: Monday, December 7, 2015

Project title: The role of 5-hydroxymethylcytosine in suicide

Project description (50-100 words suggested): Suicide is an important and complex mental health problem that imposes a significant toll on our society. As traumatic environmental experiences have a significant impact on suicide risk, most recently, a large focus has been placed on uncovering epigenomic changes that may explain this strong relationship. Recently DNA hydroxymethylation (hmC), which arises from the oxidation of methylated cytosines, was brought to the forefront of epigenetic research. This project will aim to (1) validate differentially hydroxymethylated regions from genome-wide data and (2) correlate hmC at these loci with their respective gene expression levels. Together, this work will provide insight into the putative function of hmC in post-mortem human brain.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor. Details of the evaluation scheme will be provided by HGEN to supervisors and applicants.

Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.

How students can apply / Next steps: For HGEN: After all of the parts of this application forms are completed and the hard copy is signed by the professor and the student, bring the application form and a copy of your unofficial transcript to the Department of Human Genetics (to the attention of Dr. Patricia N. Tonin, Stewart Biology Building N5.13) during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Human subjects; Biohazardous substances; Handling chemicals.