The epigenetics of rhabdomyosarcoma tumorigenesis - HGEN 396 Undergraduate Research Project Application Form

Supervisor's Name: Vahab Soleimani

Supervisor's Email: vahab.soleimani [at] mcgill.ca

Supervisor's Phone: (514) 340-8222 ext 6136

Supervisor's Website: http://www.ladydavis.ca/en/vahabsoleimani

Supervisor's department: Human Genetics

Course number: HGEN 396 (Human Genetics)

Term: Fall 2015-2016

Project start date: Friday, September 4, 2015

Project end date: Monday, December 7, 2015

Project title: The epigenetics of rhabdomyosarcoma tumorigenesis

Project description (50-100 words suggested): Rhabdomyosarcoma (RMS) is a heterogeneous group of malignancies that predominantly affect children and adolescents. Recent evidence suggests that the tumor arises from cells within the skeletal muscle tissue. The RMS tumor cells have the same gene signature as the activated muscle stem cell. However, unlike muscle stem cell, RMS tumor cell escape the normal balance of cell growth and differentiation. In this project we aim to use gene expression analysis and chromatin immnunoprecipitation to uncover the epigenetic alterations that underlie RMS tumorigenesis.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): laboratory work (40%), written report (50%), oral presentation (10%)

Project status: This project is open to applicant.

How students can apply / Next steps: For HGEN: After all of the parts of this application forms are completed and the hard copy is signed by the professor and the student, bring the application form and a copy of your unofficial transcript to the Department of Human Genetics (to the attention of Dr. Patricia N. Tonin, Stewart Biology Building N5.13) during office hours. If other, please specify:

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Handling chemicals.